{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:43:02Z","timestamp":1793256182879,"version":"4.5.0"},"reference-count":78,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"722","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2023,11,15]]},"abstract":"<jats:p>\n            Sequential infection with multiple dengue virus (DENV) serotypes is thought to induce enduring protection against dengue disease. However, long-term antibody waning has been observed after repeated DENV infection. Here, we provide evidence that highly immune Nicaraguan children and adults (\n            <jats:italic>n<\/jats:italic>\n            = 4478) experience boosting and waning of antibodies during and after major Zika and dengue epidemics. We develop a susceptible-infected-recovered-susceptible (SIRS-type) model that tracks immunity by titer rather than number of infections to show that boosts in highly immune individuals can contribute to herd immunity, delaying their susceptibility to transmissible infection. In contrast, our model of lifelong immunity in highly immune individuals, as previously assumed, results in complete disease eradication after introduction. Periodic epidemics under this scenario can only be sustained with a constant influx of infected individuals into the population or a high basic reproductive number. We also find that Zika virus infection can boost DENV immunity and produce delays and then surges in dengue epidemics, as observed with real epidemiological data. This work provides insight into factors shaping periodicity in dengue incidence and may inform vaccine efforts to maintain population immunity.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.adi1734","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:58:34Z","timestamp":1700074714000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":26,"title":["Effects of boosting and waning in highly exposed populations on dengue epidemic dynamics"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4588-4914","authenticated-orcid":true,"given":"Rosemary A.","family":"Aogo","sequence":"first","affiliation":[{"name":"Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-6173","authenticated-orcid":true,"given":"Jose Victor","family":"Zambrana","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14007, Nicaragua."},{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-3895","authenticated-orcid":true,"given":"Nery","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14007, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-2306","authenticated-orcid":true,"given":"Sergio","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14007, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-173X","authenticated-orcid":true,"given":"Guillermina","family":"Kuan","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14007, Nicaragua."},{"name":"Centro de Salud S\u00f3crates Flores Vivas, Ministry of Health, Managua 12014, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Balmaseda","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14007, Nicaragua."},{"name":"Laboratorio Nacional de Virolog\u00eda, Centro Nacional de Diagn\u00f3stico y Referencia, Ministry of Health, Managua 16064, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9352-7877","authenticated-orcid":true,"given":"Aubree","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-4037","authenticated-orcid":true,"given":"Eva","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-6758","authenticated-orcid":true,"given":"Leah C.","family":"Katzelnick","sequence":"additional","affiliation":[{"name":"Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"S. 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