{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:14:15Z","timestamp":1791512055183,"version":"4.3.4"},"reference-count":73,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"778","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2024,12,18]]},"abstract":"<jats:p>Excessive deposition of fibrillar collagen in the interstitial extracellular matrix (ECM) of human lung tissue causes fibrosis, which can ultimately lead to organ failure. Despite our understanding of the molecular mechanisms underlying the disease, no cure for pulmonary fibrosis has yet been found. We screened a drug library and found that dextromethorphan (DXM), a cough expectorant, reduced the amount of excess fibrillar collagen deposited in the ECM in cultured primary human lung fibroblasts, a bleomycin mouse model, and a cultured human precision-cut lung slice model of lung fibrosis. The reduced extracellular fibrillar collagen upon DXM treatment was due to reversible trafficking inhibition of collagen type I (COL1) in the endoplasmic reticulum (ER) in TANGO1- and HSP47-positive structures. Mass spectrometric analysis showed that DXM promoted hyperhydroxylation of proline and lysine residues on various collagens (COL1, COL3, COL4, COL5, COL7, and COL12) and latent transforming growth factor\u2013\u03b2\u2013binding protein (LTBP1 and LTBP2) peptides, coinciding with their secretion block. Additionally, proteome profiling of DXM-treated cells showed increased thermal stability of prolyl-hydroxylases P3H2, P3H3, P3H4, P4HA1, and P4HA2, suggesting a change in their activity. Transcriptome analysis of profibrotic stimulated primary human lung fibroblasts and human ex vivo lung slices after DXM treatment showed activation of an antifibrotic program through regulation of multiple pathways, including the MMP-ADAMTS axis, WNT signaling, and fibroblast-to-myofibroblast differentiation. Together, these data obtained from in vitro, in vivo, and ex vivo models of lung fibrogenesis show that DXM has the potential to limit fibrosis through inhibition of COL1 membrane trafficking in the ER.<\/jats:p>","DOI":"10.1126\/scitranslmed.adj3087","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T19:00:17Z","timestamp":1734548417000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":16,"title":["Dextromethorphan inhibits collagen and collagen-like cargo secretion to ameliorate lung fibrosis"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-0251","authenticated-orcid":true,"given":"Muzamil M.","family":"Khan","sequence":"first","affiliation":[{"name":"Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."},{"name":"Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-2726","authenticated-orcid":true,"given":"George","family":"Galea","sequence":"additional","affiliation":[{"name":"Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Jung","sequence":"additional","affiliation":[{"name":"Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8287-7428","authenticated-orcid":true,"given":"Joanna","family":"Zukowska","sequence":"additional","affiliation":[{"name":"Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2919-3451","authenticated-orcid":true,"given":"David","family":"Lauer","sequence":"additional","affiliation":[{"name":"Lung Precision Medicine (LPM), Department for BioMedical Research (DBMR), University of Bern, 3008 Bern, Switzerland."},{"name":"Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."},{"name":"Department of Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8125-3098","authenticated-orcid":true,"given":"Nadine","family":"Tuechler","sequence":"additional","affiliation":[{"name":"Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."},{"name":"Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and Heidelberg University, 69117 Heidelberg, Germany."},{"name":"Institute for Computational Biomedicine (ICB), Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9002-457X","authenticated-orcid":true,"given":"Aliaksandr","family":"Halavatyi","sequence":"additional","affiliation":[{"name":"Advanced Light Microscopy Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4105-1990","authenticated-orcid":true,"given":"Christian","family":"Tischer","sequence":"additional","affiliation":[{"name":"Advanced Light Microscopy Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5608-9062","authenticated-orcid":true,"given":"Per","family":"Haberkant","sequence":"additional","affiliation":[{"name":"Proteomics Core Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9695-1692","authenticated-orcid":true,"given":"Frank","family":"Stein","sequence":"additional","affiliation":[{"name":"Proteomics Core Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-7832","authenticated-orcid":true,"given":"Ferris","family":"Jung","sequence":"additional","affiliation":[{"name":"Genomics Core Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2262-9099","authenticated-orcid":true,"given":"Jonathan J. M.","family":"Landry","sequence":"additional","affiliation":[{"name":"Genomics Core Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif M.","family":"Khan","sequence":"additional","affiliation":[{"name":"Centre for Bioimage Analysis, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8122-8271","authenticated-orcid":true,"given":"Viola","family":"Oorschot","sequence":"additional","affiliation":[{"name":"Electron Microscopy Core Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7170-2235","authenticated-orcid":true,"given":"Isabelle","family":"Becher","sequence":"additional","affiliation":[{"name":"Genome Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-502X","authenticated-orcid":true,"given":"Beate","family":"Neumann","sequence":"additional","affiliation":[{"name":"Advanced Light Microscopy Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8141-0604","authenticated-orcid":true,"given":"Thomas","family":"Muley","sequence":"additional","affiliation":[{"name":"Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), 69120 Heidelberg, Germany."},{"name":"Translational Research Unit\/Lung Biobank, Thoraxklinik, University Hospital Heidelberg, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5242-6942","authenticated-orcid":true,"given":"Hauke","family":"Winter","sequence":"additional","affiliation":[{"name":"Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), 69120 Heidelberg, Germany."},{"name":"Translational Research Unit\/Lung Biobank, Thoraxklinik, University Hospital Heidelberg, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4862-9487","authenticated-orcid":true,"given":"Julia","family":"Duerr","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charit\u00e9-Universit\u00e4tsmedizin, 13353 Berlin, Germany."},{"name":"German Center for Lung Research (DZL), Associated Partner Site, 13353 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4057-2199","authenticated-orcid":true,"given":"Marcus A","family":"Mall","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charit\u00e9-Universit\u00e4tsmedizin, 13353 Berlin, Germany."},{"name":"German Center for Lung Research (DZL), Associated Partner Site, 13353 Berlin, Germany."},{"name":"Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, 10178 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1081-9649","authenticated-orcid":true,"given":"Alessandro","family":"Grassi","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resources, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7078-0901","authenticated-orcid":true,"given":"Ernesto","family":"de la Cueva","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resources, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0352-2547","authenticated-orcid":true,"given":"Vladimir","family":"Benes","sequence":"additional","affiliation":[{"name":"Genomics Core Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-4936","authenticated-orcid":true,"given":"Janine","family":"Gote-Schniering","sequence":"additional","affiliation":[{"name":"Lung Precision Medicine (LPM), Department for BioMedical Research (DBMR), University of Bern, 3008 Bern, Switzerland."},{"name":"Department of Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland."},{"name":"Department of Rheumatology and Immunology, Inselspital, Bern University Hospital, 3010 Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2011-9247","authenticated-orcid":true,"given":"Mikhail","family":"Savitski","sequence":"additional","affiliation":[{"name":"Proteomics Core Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."},{"name":"Genome Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9762-3583","authenticated-orcid":true,"given":"Rainer","family":"Pepperkok","sequence":"additional","affiliation":[{"name":"Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."},{"name":"Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), 69120 Heidelberg, Germany."},{"name":"Advanced Light Microscopy Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2938-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3904"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2018.0601"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112452"},{"key":"e_1_3_2_6_2","unstructured":"IRC ERS Lung facts International Respiratory Coalition; https:\/\/international-respiratory-coalition.org\/lung-facts\/diseases\/."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0022-2019"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01458-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60052-4"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01070-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2015.00059"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.48"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2277"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125185"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.07.014"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00387.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","unstructured":"J. Sand N. Gudmann S. R\u00f8nnow S. Brockbank S. Cruwys M. Karsdal D. Leeming \u201cScar-in-a-Jar an in vitro screening tool for antifibrotics\u201d in Mechanisms of Lung Injury and Repair (European Respiratory Society 2018) vol. 52 p. PA597.","DOI":"10.1183\/13993003.congress-2018.PA597"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-020-00490-7"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0021-2019"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40800-017-0047-y"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.04.010"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00221-2020"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00118"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-4224"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna8010013"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbplus.2019.04.002"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15776"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200108073"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.05.005"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.06.003"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90075-9"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2007.00582.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80724-2"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-021-02302-2"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32723"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255784"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20199232"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01177-5"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.5b01083"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81723-7"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14197"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2410OC"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00060.2014"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050062"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103325"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0282-9_1"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00273"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700653R"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4530"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201007162"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51319"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001564RR"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28921"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00152106"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01758-2"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600892RR"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-02050-x"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.023820"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11378-8"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.3390\/life12050696"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp043"},{"key":"e_1_3_2_62_2","unstructured":"H. Botelho A. Halavatyi C. Tischer embl-cba\/shinyHTM: shinyHTM - Interactive High-Throughput Microscopy Analysis v0.1.01 Zenodo (2019); https:\/\/doi.org\/10.5281\/ZENODO.2594652."},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20145625"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.7b00913"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.101"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.046995"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.suppl_1.S96"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr645"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2185"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-420119-4.00001-X"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.006"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1534\/g3.117.300257"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adj3087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T19:00:28Z","timestamp":1734548428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adj3087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":73,"journal-issue":{"issue":"778","published-print":{"date-parts":[[2024,12,18]]}},"alternative-id":["10.1126\/scitranslmed.adj3087"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adj3087","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"2023-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-25","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadj3087"}}