{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:34:05Z","timestamp":1788194045557,"version":"build-2803163510"},"reference-count":69,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"760","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:p>Extracellular acyl-coenzyme A binding protein [ACBP encoded by diazepam binding inhibitor (DBI)] is a phylogenetically ancient appetite stimulator that is secreted in a nonconventional, autophagy-dependent fashion. Here, we show that low ACBP\/DBI plasma concentrations are associated with poor prognosis in patients with anorexia nervosa, a frequent and often intractable eating disorder. In mice, anorexia induced by chronic restraint stress (CRS) is accompanied by a reduction in circulating ACBP\/DBI concentrations. We engineered a chemical-genetic system for the secretion of ACBP\/DBI through a biotin-activatable, autophagy-independent pathway. In transgenic mice expressing this system in hepatocytes, biotin-induced elevations in plasma ACBP\/DBI concentrations prevented anorexia induced by CRS or chemotherapeutic agents including cisplatin, doxorubicin, and paclitaxel. ACBP\/DBI reversed the CRS or cisplatin-induced increase in plasma lipocalin-2 concentrations and the hypothalamic activation of anorexigenic melanocortin 4 receptors, for which lipocalin-2 is an agonist. Daily intravenous injections of recombinant ACBP\/DBI protein or subcutaneous implantation of osmotic pumps releasing recombinant ACBP\/DBI mimicked the orexigenic effects of the chemical-genetic system. In conclusion, the supplementation of extracellular and peripheral ACBP\/DBI might constitute a viable strategy for treating anorexia.<\/jats:p>","DOI":"10.1126\/scitranslmed.adl0715","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T17:58:31Z","timestamp":1723658311000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":15,"title":["Acyl-CoA binding protein for the experimental treatment of anorexia"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-8617","authenticated-orcid":true,"given":"Hui","family":"Chen","sequence":"first","affiliation":[{"name":"Centre de Recherche des Cordeliers, Equipe labellis\u00e9e par la Ligue contre le cancer, Inserm U1138, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006 Paris, France."},{"name":"Metabolomics and Cell Biology Platforms, Gustave Roussy Institut, 94805 Villejuif, 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