{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:40:50Z","timestamp":1792737650846,"version":"4.5.0"},"reference-count":61,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"800","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2025,5,28]]},"abstract":"<jats:p>\n            CD4\n            <jats:sup>+<\/jats:sup>\n            CD25\n            <jats:sup>hi<\/jats:sup>\n            FoxP3\n            <jats:sup>+<\/jats:sup>\n            regulatory T cells (T\n            <jats:sub>reg<\/jats:sub>\n            cells) are key controllers of immune self-tolerance, and their suppressive function is impaired in people with relapsing-remitting multiple sclerosis (pwRR-MS). Because the mechanisms underlying this condition are still ill-defined, we investigated the role of T\n            <jats:sub>reg<\/jats:sub>\n            cell\u2013derived extracellular vesicles (T\n            <jats:sub>reg<\/jats:sub>\n            -EVs) in T\n            <jats:sub>reg<\/jats:sub>\n            cell dysfunction observed in pwRR-MS. We found that T\n            <jats:sub>reg<\/jats:sub>\n            -EVs from healthy individuals inhibit CD4\n            <jats:sup>+<\/jats:sup>\n            conventional T (T\n            <jats:sub>conv<\/jats:sub>\n            ) cells by shuttling miR-142-3p from the T\n            <jats:sub>reg<\/jats:sub>\n            cell to the T\n            <jats:sub>conv<\/jats:sub>\n            cell. There, miR-142-3p down-regulated mRNAs necessary for T\n            <jats:sub>conv<\/jats:sub>\n            cell growth and effector functions, such as the redox controller cystine carrier\n            <jats:italic toggle=\"yes\">SLC7A11<\/jats:italic>\n            . However, T\n            <jats:sub>reg<\/jats:sub>\n            cells from pwRR-MS released EVs containing reduced amounts of miR-142-3p, resulting in impaired suppressive function. Furthermore, T\n            <jats:sub>reg<\/jats:sub>\n            -EV miR-142-3p inversely correlated with the disability score and gadolinium-enhancing lesions in pwRR-MS. Together, our results elucidate a molecular mechanism involving miR-142-3p shuttled by T\n            <jats:sub>reg<\/jats:sub>\n            -EVs in the control of immune self-tolerance and unveil its pathogenetic implications in human autoimmunity.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.adl1698","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T17:58:31Z","timestamp":1748455111000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["MicroRNA-142-3p shuttling in extracellular vesicles marks regulatory T cell dysfunction in multiple sclerosis"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-9034","authenticated-orcid":true,"given":"Giusy","family":"De Rosa","sequence":"first","affiliation":[{"name":"Laboratorio di Immunologia, Istituto degli Endotipi in Oncologia, Metabolismo e Immunologia \u201cG. Salvatore\u201d, Consiglio Nazionale delle Ricerche (IEOMI-CNR), 80131 Napoli, Italy."},{"name":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, 80131 Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5869-4445","authenticated-orcid":true,"given":"Claudia","family":"Russo","sequence":"additional","affiliation":[{"name":"Laboratorio di Immunologia, Istituto degli Endotipi in Oncologia, Metabolismo e Immunologia \u201cG. Salvatore\u201d, Consiglio Nazionale delle Ricerche (IEOMI-CNR), 80131 Napoli, Italy."},{"name":"Azienda Ospedaliera Universitaria Federico II, 80131 Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Garavelli","sequence":"additional","affiliation":[{"name":"Laboratorio di Immunologia, Istituto degli Endotipi in Oncologia, Metabolismo e Immunologia \u201cG. 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