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Datasets using animal model serum samples showed higher titer magnitudes than datasets using human serum samples in this comparison. Fold change in neutralization of variants compared to ancestral SARS-CoV-2, immunodominance patterns, and antigenic maps were similar among serum samples and assays. Most assays yielded consistent results, except for differences in fold change in cytopathic effect assays. Hamster serum samples were a consistent surrogate for human first-infection serum samples. These results inform the transition of surveillance of SARS-CoV-2 antigenic variation from dependence on human first-infection serum samples to the utilization of serum samples from animal models.<\/jats:p>","DOI":"10.1126\/scitranslmed.adl1722","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T17:58:51Z","timestamp":1715795931000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":18,"title":["Comparative analysis of SARS-CoV-2 neutralization titers reveals consistency between human and animal model serum and across assays"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-8530","authenticated-orcid":true,"given":"Barbara","family":"M\u00fchlemann","sequence":"first","affiliation":[{"name":"Institute of Virology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany."},{"name":"German Centre for Infection Research (DZIF), partner site Charit\u00e9, 10117 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-8474","authenticated-orcid":true,"given":"Samuel H.","family":"Wilks","sequence":"additional","affiliation":[{"name":"Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Baracco","sequence":"additional","affiliation":[{"name":"Center for Pathogen Research, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Bekliz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland."},{"name":"Centre for Emerging Viral Diseases, University Hospitals of Geneva and University of Geneva, CH-1211, Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-9275","authenticated-orcid":true,"given":"Juan Manuel","family":"Carre\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-0136","authenticated-orcid":true,"given":"Victor M.","family":"Corman","sequence":"additional","affiliation":[{"name":"Institute of Virology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany."},{"name":"German Centre for Infection Research (DZIF), partner site Charit\u00e9, 10117 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-3613","authenticated-orcid":true,"given":"Meredith E.","family":"Davis-Gardner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory Vaccine Center, Emory National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7996-2699","authenticated-orcid":true,"given":"Wanwisa","family":"Dejnirattisai","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK."},{"name":"Division of Emerging Infectious Disease, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-3165","authenticated-orcid":true,"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Molecular Microbiology, Pathology &amp; Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Andrew M. and Jane M. 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