{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:30:30Z","timestamp":1792531830956,"version":"4.5.0"},"reference-count":86,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"761","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2024,8,21]]},"abstract":"<jats:p>Respiratory failure occurs more frequently after thoracic surgery than abdominal surgery. Although the etiology for this complication is frequently attributed to underlying lung disease present in patients undergoing thoracic surgery, this notion is often unfounded because many patients with normal preoperative pulmonary function often require prolonged oxygen supplementation even after minimal resection of lung tissue. Using a murine model of pulmonary resection and peripheral blood samples from patients undergoing resection of the lung or abdominal organs, we demonstrated that lung surgery initiates a proinflammatory loop that results in damage to the remaining lung tissue, noncardiogenic pulmonary edema, hypoxia, and even death. Specifically, we demonstrated that resection of murine lung tissue increased concentrations of the homeostatic cytokine interleukin-7, which led to local and systemic activation of type 2 innate lymphoid cells. This process activated lung-resident eosinophils and facilitated stress-induced eosinophil maturation in the bone marrow in a granulocyte-macrophage colony-stimulating factor\u2013dependent manner, resulting in systemic eosinophilia in both mice and humans. Up-regulation of inducible nitric oxide synthase in lung-resident eosinophils led to tissue nitrosylation, pulmonary edema, hypoxia, and, at times, death. Disrupting this activation cascade at any stage ameliorated deleterious outcomes and improved survival after lung resection in the mouse model. Our data suggest that repurposing US Food and Drug Administration\u2013approved eosinophil-targeting strategies may potentially offer a therapeutic intervention to improve outcomes for patients who require lung resection for benign or malignant etiology.<\/jats:p>","DOI":"10.1126\/scitranslmed.adl4222","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T22:26:29Z","timestamp":1724279189000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Stress-induced eosinophil activation contributes to postoperative morbidity and mortality after lung resection"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0602-839X","authenticated-orcid":true,"given":"Zhongcheng","family":"Mei","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May A.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7627-6423","authenticated-orcid":true,"given":"Yizhan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, MD 21201, USA."},{"name":"Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7205-353X","authenticated-orcid":true,"given":"Dongge","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7678-1868","authenticated-orcid":true,"given":"Anirban","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5252-1631","authenticated-orcid":true,"given":"Mojtaba","family":"Taheri","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Kratzmeier","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8883-1535","authenticated-orcid":true,"given":"Kelly","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9921-0598","authenticated-orcid":true,"given":"Christine L.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina G.","family":"Luzina","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-0370","authenticated-orcid":true,"given":"Sergei P.","family":"Atamas","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaveera","family":"Kandasamy","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7711-8651","authenticated-orcid":true,"given":"Daniel","family":"Kreisel","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA."},{"name":"Department of Surgery, Washington University in St. Louis, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-6343","authenticated-orcid":true,"given":"Andrew E.","family":"Gelman","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA."},{"name":"Department of Surgery, Washington University in St. Louis, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2956-753X","authenticated-orcid":true,"given":"Elizabeth A.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, AZ 85054, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1790-6197","authenticated-orcid":true,"given":"Alexander Sasha","family":"Krupnick","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, MD 21201, USA."},{"name":"Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"161","article-title":"Current trends in thoracic surgery","volume":"82","author":"Chen-Yoshikawa T. F.","year":"2020","unstructured":"T. F. Chen-Yoshikawa, T. Fukui, S. Nakamura, T. Ito, Y. Kadomatsu, H. Tsubouchi, H. Ueno, T. Sugiyama, M. Goto, S. Mori, N. Ozeki, S. Hakiri, K. Kawaguchi, Current trends in thoracic surgery. Nagoya J. Med. Sci. 82, 161\u2013174 (2020).","journal-title":"Nagoya J. Med. Sci."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.09.135"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.5.1263"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2021.11.100"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.07.025"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(93)90443-L"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.5.1216"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0096-5588(20)31969-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.06.021"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(96)80392-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.12.061"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2006.05.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.1.320"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)00879-8"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAF.0b013e31823d29ad"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01322.2009"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.11.019"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200202)32:2<585::AID-IMMU585>3.0.CO;2-U"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050548"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400732"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1382"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12321"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12244"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03816.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012047"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.1MR1117-442RR"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.08.015"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.025"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761997000800010"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116141"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3341"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02718"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.4.1035"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.3.1404"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2020.09.001"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.29"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2012.03.002"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0479-x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.01.012"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17084"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016080877"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxad029"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.757967"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161653"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00943-z"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.008"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.044"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190706"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxab062"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200817"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004030"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.96455"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.128241"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03860.x"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3AB1117-455R"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.2.2004187"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2110017"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00193-3"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-093019-125918"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-021-00870-z"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012419-032756"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-019-0867-1"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac9593"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0425-3"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114630"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.03.023"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12526"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80294-0"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.11.002"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.4.1666"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830261040"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(98)80075-2"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1996.0182"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.975914"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00985"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001868"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.747324"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-347823"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1159\/000510352"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-1219-1"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.06.005"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000105118.66983.19"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxt012"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01819.x"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-0839"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.5936"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adl4222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T22:26:45Z","timestamp":1724279205000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adl4222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,21]]},"references-count":86,"journal-issue":{"issue":"761","published-print":{"date-parts":[[2024,8,21]]}},"alternative-id":["10.1126\/scitranslmed.adl4222"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adl4222","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,21]]},"assertion":[{"value":"2023-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadl4222"}}