{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:38:52Z","timestamp":1793882332634,"version":"4.7.0"},"reference-count":44,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"740","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2024,3,27]]},"abstract":"<jats:p>The 2022\u20132023 mpox outbreak triggered vaccination efforts using smallpox vaccines that were approved for mpox, including modified vaccinia Ankara (MVA; JYNNEOS), which is a safer alternative to live replicating vaccinia virus (ACAM2000). Here, we compare the immunogenicity and protective efficacy of JYNNEOS by the subcutaneous or intradermal routes, ACAM2000 by the percutaneous route, and subunit Ad35 vector\u2013based L1R\/B5R or L1R\/B5R\/A27L\/A33R vaccines by the intramuscular route in rhesus macaques. All vaccines provided robust protection against high-dose intravenous mpox virus challenge with the current outbreak strain, with ACAM2000 providing near complete protection and JYNNEOS and Ad35 vaccines providing robust but incomplete protection. Protection correlated with neutralizing antibody responses as well as L1R\/M1R- and B5R\/B6R-specific binding antibody responses, although additional immune responses likely also contributed to protection. This study demonstrates the protective efficacy of multiple vaccine platforms against mpox virus challenge, including both current clinical vaccines and vectored subunit vaccines.<\/jats:p>","DOI":"10.1126\/scitranslmed.adl4317","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T14:00:54Z","timestamp":1711548054000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":44,"title":["Comparison of the immunogenicity and protective efficacy of ACAM2000, MVA, and vectored subunit vaccines for Mpox in rhesus macaques"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-0342","authenticated-orcid":true,"given":"Catherine","family":"Jacob-Dolan","sequence":"first","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."},{"name":"Department of Immunology, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2411-8658","authenticated-orcid":true,"given":"Darren","family":"Ty","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5654-1744","authenticated-orcid":true,"given":"David","family":"Hope","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-0539","authenticated-orcid":true,"given":"Katherine","family":"McMahan","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-2181","authenticated-orcid":true,"given":"Jinyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9329-427X","authenticated-orcid":true,"given":"Olivia C.","family":"Powers","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-3305","authenticated-orcid":true,"given":"Catherine A.","family":"Cotter","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MA 20852, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-7625","authenticated-orcid":true,"given":"Michela","family":"Sciacca","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-5346","authenticated-orcid":true,"given":"Cindy","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Borducchi","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Bouffard","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7120-2910","authenticated-orcid":true,"given":"Hannah","family":"Richter","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Velasco","sequence":"additional","affiliation":[{"name":"Bioqual, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyse","family":"Teow","sequence":"additional","affiliation":[{"name":"Bioqual, Rockville, MD 20850, 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USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-3562","authenticated-orcid":true,"given":"Michael S.","family":"Seaman","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-3008","authenticated-orcid":true,"given":"Laurent","family":"Pessiant","sequence":"additional","affiliation":[{"name":"Bioqual, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7852-0135","authenticated-orcid":true,"given":"Mark G.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Bioqual, Rockville, MD 20850, 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Boston, MA 02115, USA."},{"name":"Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"CDC https:\/\/cdc.gov\/poxvirus\/mpox\/response\/2022\/world-map.html (2023)."},{"key":"e_1_3_2_3_2","unstructured":"CDC https:\/\/cdc.gov\/poxvirus\/mpox\/response\/2022\/index.html (2023)."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2215751"},{"key":"e_1_3_2_5_2","unstructured":"M. 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Gruber Biological License Application approval letter for MVA-BN vaccine Bavarian Nordic (Food and Drug Administration 2019)."},{"key":"e_1_3_2_6_2","unstructured":"World Health Organization \"Background document for the SAGE October 2022 session on monkeypox vaccines \u201d 16 November 2022; www.who.int\/publications\/i\/item\/WHO-MPX-Immunization-Background-2022."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.4.555"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03481-12"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042353"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.07.030"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.9.4433-4443.2004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.023"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.06.075"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.32607\/actanaturae.11857"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2552"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00353-08"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2215201"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad645"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00057-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02229-3"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7220a3"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7220a4"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7149a5"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","unstructured":"M. S. Ramchandani A. Berzkalns C. A. Cannon J. C. Dombrowski E. Brown E. J. Chow E. Barash S. Pogosjans D. Smith M. R. Golden in Open Forum Infectious Diseases. (Oxford University Press US 2023) vol. 10 ofad528.","DOI":"10.1093\/ofid\/ofad528"},{"key":"e_1_3_2_25_2","first-page":"2200883","article-title":"Post-exposure vaccine effectiveness and contact management in the mpox outbreak, Madrid, Spain, May to August 2022","volume":"28","author":"Morales L. M.","year":"2023","unstructured":"L. M. Morales, J. F. B. Del Buey, M. A. Garc\u00eda, N. C. Largo, A. N. Juli\u00e1, M. C. V. Torres, S. J. Bueno, A. A. Pe\u00f1a, E. G. Montalb\u00e1n, J. \u00cd. Mart\u00ednez, Post-exposure vaccine effectiveness and contact management in the mpox outbreak, Madrid, Spain, May to August 2022. 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