{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:33:28Z","timestamp":1791542008657,"version":"4.3.4"},"reference-count":55,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"747","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2024,5,15]]},"abstract":"<jats:p>\n            Endovascular interventions are increasingly becoming the preferred approach for treating strokes and cerebral artery diseases. These procedures rely on sophisticated angiographical imaging guidance, which encounters challenges because of limited contrast and spatial resolution. Achieving a more precise visualization of the underlying arterial pathology and neurovascular implants is crucial for accurate procedural decision-making. In a human study involving 32 patients, we introduced the clinical application of a miniaturized endovascular neuro optical coherence tomography (\n            <jats:italic>n<\/jats:italic>\n            OCT) imaging probe. This technology was designed to navigate the tortuous paths of the cerebrovascular circulation and to offer high-resolution imaging in situ. The\n            <jats:italic>n<\/jats:italic>\n            OCT probe is compatible with standard neurovascular microcatheters, integrating with the procedural workflow used in clinical routine. Equipped with a miniaturized optical fiber and a distal lens, the probe illuminates the tissue and collects the backscattered, near-infrared light. While rotating the fiber and the lens at high speed, the probe is rapidly retracted, creating a spiral-shaped light pattern to comprehensively capture the arterial wall and implanted devices. Using\n            <jats:italic>n<\/jats:italic>\n            OCT, we demonstrated volumetric microscopy of cerebral arteries in patients undergoing endovascular procedures. We imaged the anterior and posterior circulation of the brain, including distal segments of the internal carotid and middle-cerebral arteries, as well as the vertebral, basilar, and posterior cerebral arteries. We captured a broad spectrum of neurovascular pathologies, such as brain aneurysms, ischemic stroke, arterial stenoses, dissections, and intracranial atherosclerotic disease.\n            <jats:italic>n<\/jats:italic>\n            OCT offered artifact-free, high-resolution visualizations of intracranial artery pathology and neurovascular devices.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.adl4497","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T17:58:51Z","timestamp":1715795931000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":27,"title":["Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6804-3985","authenticated-orcid":true,"given":"Vitor M.","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, St Michael\u2019s Hospital, Toronto, ON M5B 1W8, Canada."},{"name":"RADIS Lab, Li Ka Shing Knowledge Institute, St Michael\u2019s Hospital, Toronto, ON M5B 1W8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-4369","authenticated-orcid":true,"given":"Pedro","family":"Lylyk","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Cl\u00ednica Sagrada Familia, Buenos Aires, CABA C1426, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-4304","authenticated-orcid":true,"given":"Nicole","family":"Cancelliere","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, St Michael\u2019s Hospital, Toronto, ON M5B 1W8, Canada."},{"name":"RADIS Lab, Li Ka Shing Knowledge Institute, St Michael\u2019s Hospital, Toronto, ON M5B 1W8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-2175","authenticated-orcid":true,"given":"Pedro N.","family":"Lylyk","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Cl\u00ednica Sagrada Familia, Buenos Aires, CABA C1426, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6048-4225","authenticated-orcid":true,"given":"Ivan","family":"Lylyk","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Cl\u00ednica Sagrada Familia, Buenos Aires, CABA C1426, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania","family":"Anagnostakou","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Bleise","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Cl\u00ednica Sagrada Familia, Buenos Aires, CABA C1426, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1763-2517","authenticated-orcid":true,"given":"Hidehisa","family":"Nishi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, St Michael\u2019s Hospital, Toronto, ON M5B 1W8, Canada."},{"name":"RADIS Lab, Li Ka Shing Knowledge Institute, St Michael\u2019s Hospital, Toronto, ON M5B 1W8, Canada."},{"name":"Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8303, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1164-7331","authenticated-orcid":true,"given":"Mark","family":"Epshtein","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5144-9110","authenticated-orcid":true,"given":"Robert M.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-8098","authenticated-orcid":true,"given":"Mohammed Salman","family":"Shazeeb","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit S.","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8694-6427","authenticated-orcid":true,"given":"Conrad W.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kaiser Permanente Fontana Medical Center, Fontana, CA 92335, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7195-5806","authenticated-orcid":true,"given":"Ricardo A.","family":"Hanel","sequence":"additional","affiliation":[{"name":"Lyerly Neurosurgery, Baptist Medical Center Jacksonville, Jacksonville, FL 32207, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Spears","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, St Michael\u2019s Hospital, Toronto, ON M5B 1W8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-2054","authenticated-orcid":true,"given":"Thomas R.","family":"Marotta","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, St Michael\u2019s Hospital, Toronto, ON M5B 1W8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6280-0113","authenticated-orcid":true,"given":"Demetrius K.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brain and Spine Institute, Advocate Health, Chicago, IL 60453, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8034-2785","authenticated-orcid":true,"given":"Matthew J.","family":"Gounis","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-0698","authenticated-orcid":true,"given":"Giovanni J.","family":"Ughi","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA."},{"name":"Department of Medical Affairs, Gentuity LLC, Sudbury, MA 01776, USA."},{"name":"Department of Advanced Development, Spryte Medical, Bedford, MA 01730, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2214403"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70015-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.678151"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105335"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4848"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyaa208"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyy092"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-020-02482-w"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019818"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-011843"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1450"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00687-9"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.020834"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2011-010102"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022315"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015660"},{"key":"e_1_3_2_18_2","first-page":"1141","article-title":"Optical coherence tomography imaging after endovascular thrombectomy for basilar artery occlusion: Report of 3 cases","volume":"113","author":"Pasarikovski C. R.","year":"2019","unstructured":"C. R. Pasarikovski, J. Ramjist, L. da Costa, S. E. Black, V. Yang, Optical coherence tomography imaging after endovascular thrombectomy for basilar artery occlusion: Report of 3 cases. J. Neurosurg. 113, 1141\u20131146 (2019).","journal-title":"J. Neurosurg."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00858"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207345"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17702-7"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.079"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2022-019275"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013502"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000140636.30204.da"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1978.48.4.0505"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301227"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.06.004"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.757175"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.01.031"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000152331.93770.18"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.07.030"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.545"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I4A77"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.003543"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2021-018544"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.05.013"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-016447"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-014843"},{"key":"e_1_3_2_40_2","first-page":"jnis-2023-02052","article-title":"A novel intrasaccular aneurysm device with high complete occlusion rate: Initial results in a rabbit model","author":"Zoppo C. T.","year":"2023","unstructured":"C. T. Zoppo, J. W. Kolstad, R. M. King, T. Wolfe, A. Kraitem, Z. Vardar, A. Badruddin, E. Pereira, B. P. Guerrero, A. S. Rosqueta, G. J. Ughi, M. J. Gounis, O. O. Zaidat, V. Anagnostakou, A novel intrasaccular aneurysm device with high complete occlusion rate: Initial results in a rabbit model. J. Neurointerv. Surg., jnis-2023-020520 (2023).","journal-title":"J. Neurointerv. Surg."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017162096"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4835"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/1591019915583217"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00512"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026738"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031518"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.06.218"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-40363-7"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.01.013"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-020-01795-8"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy285"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp433"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv642"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.3280271"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000044384.41037.43"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199231158444"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adl4497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T17:58:55Z","timestamp":1715795935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adl4497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,15]]},"references-count":55,"journal-issue":{"issue":"747","published-print":{"date-parts":[[2024,5,15]]}},"alternative-id":["10.1126\/scitranslmed.adl4497"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adl4497","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,15]]},"assertion":[{"value":"2023-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadl4497"}}