{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:40:46Z","timestamp":1793936446420,"version":"4.8.0"},"reference-count":101,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"776","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2024,12,4]]},"abstract":"<jats:p>\n            Niemann-Pick type C (NPC) disease is an inherited lysosomal storage disorder mainly driven by mutations in the\n            <jats:italic>NPC1<\/jats:italic>\n            gene, causing lipid accumulation within late endosomes\/lysosomes and resulting in progressive neurodegeneration. Although microglial activation precedes neuronal loss, it remains elusive whether loss of the membrane protein NPC1 in microglia actively contributes to NPC pathology. In a mouse model with depletion of NPC1 in myeloid cells, we report severe alterations in microglial lipidomic profiles, including the enrichment of bis(monoacylglycero)phosphate, increased cholesterol, and a decrease in cholesteryl esters. Lipid dyshomeostasis was associated with microglial hyperactivity, marked by an increase in translocator protein 18 kDa (TSPO). These hyperactive microglia initiated a pathological cascade resembling NPC-like phenotypes, including a shortened life span, motor impairments, astrogliosis, neuroaxonal pathology, and increased neurofilament light chain (NF-L), a neuronal injury biomarker. As observed in the mouse model, patients with NPC showed increased NF-L in the blood and microglial hyperactivity, as visualized by TSPO-PET imaging. Reduced TSPO expression in blood-derived macrophages of patients with NPC was measured after\n            <jats:italic>N<\/jats:italic>\n            -acetyl-\n            <jats:sc>l<\/jats:sc>\n            -leucine treatment, which has been recently shown to have beneficial effects in patients with NPC, suggesting that TSPO is a potential marker to monitor therapeutic interventions for NPC. Conclusively, these results demonstrate that myeloid dysfunction, driven by the loss of NPC1, contributes to NPC disease and should be further investigated for therapeutic targeting and disease monitoring.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.adl4616","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T18:58:53Z","timestamp":1733338733000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":26,"title":["Myeloid cell\u2013specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5380-3152","authenticated-orcid":true,"given":"Lina","family":"Dinkel","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2902-6082","authenticated-orcid":true,"given":"Selina","family":"Hummel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2127-6267","authenticated-orcid":true,"given":"Valerio","family":"Zenatti","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6417-9685","authenticated-orcid":true,"given":"Mariagiovanna","family":"Malara","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannik","family":"Tillmann","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Colombo","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7864-7400","authenticated-orcid":true,"given":"Laura Sebastian","family":"Monasor","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8119-326X","authenticated-orcid":true,"given":"Jung H.","family":"Suh","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2081-782X","authenticated-orcid":true,"given":"Todd","family":"Logan","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-2981","authenticated-orcid":true,"given":"Stefan","family":"Roth","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8716-3483","authenticated-orcid":true,"given":"Lars","family":"Paeger","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9728-8162","authenticated-orcid":true,"given":"Patricia","family":"Hoffelner","sequence":"additional","affiliation":[{"name":"Department of Physiological Genomics, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 82152 Planegg-Martinsried, Germany."},{"name":"Graduate School of Systemic Neurosciences, Ludwig Maximilian University, 82152 Planegg-Martinsried, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9426-0325","authenticated-orcid":true,"given":"Oliver","family":"Bludau","sequence":"additional","affiliation":[{"name":"Department of Physiological Genomics, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 82152 Planegg-Martinsried, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-0777","authenticated-orcid":true,"given":"Andree","family":"Schmidt","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."},{"name":"Graduate School of Systemic Neurosciences, Ludwig Maximilian University, 82152 Planegg-Martinsried, Germany."},{"name":"Neuroproteomics School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3414-307X","authenticated-orcid":true,"given":"Stephan A.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."},{"name":"Neuroproteomics School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-8218","authenticated-orcid":true,"given":"Martina","family":"Schifferer","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Nuscher","sequence":"additional","affiliation":[{"name":"Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasenka Rudan","family":"Njavro","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Prestel","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6158-319X","authenticated-orcid":true,"given":"Laura M.","family":"Bartos","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-1873","authenticated-orcid":true,"given":"Karin","family":"Wind-Mark","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."},{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"Slemann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9074-3474","authenticated-orcid":true,"given":"Leonie","family":"Hoermann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3543-5329","authenticated-orcid":true,"given":"Sebastian T.","family":"Kunte","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1554-7765","authenticated-orcid":true,"given":"Johannes","family":"Gn\u00f6rich","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4379-4436","authenticated-orcid":true,"given":"Simon","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Simons","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."},{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, 81377 Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany."},{"name":"Institute of Neuronal Cell Biology (TUM-NZB), Technical University of Munich, 80802 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Herms","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany."},{"name":"Center for Neuropathology and Prion Research, Ludwig-Maximilians-University M\u00fcnchen, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2065-1639","authenticated-orcid":true,"given":"Dominik","family":"Paquet","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, 81377 Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-2575","authenticated-orcid":true,"given":"Stefan F.","family":"Lichtenthaler","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."},{"name":"Neuroproteomics School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0734-4994","authenticated-orcid":true,"given":"Peter","family":"Bartenstein","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-2283","authenticated-orcid":true,"given":"Nicolai","family":"Franzmeier","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, 81377 Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany."},{"name":"Department of Psychiatry and Neurochemistry, University of Gothenburg, Sahlgrenska Academy, Institute of Neuroscience and Physiology, SE-413 90 M\u00f6lndal and Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9069-2594","authenticated-orcid":true,"given":"Arthur","family":"Liesz","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, 81377 Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0338-7530","authenticated-orcid":true,"given":"Antje","family":"Grosche","sequence":"additional","affiliation":[{"name":"Department of Physiological Genomics, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 82152 Planegg-Martinsried, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7397-045X","authenticated-orcid":true,"given":"Tatiana","family":"Bremova-Ertl","sequence":"additional","affiliation":[{"name":"Department of Neurology, LMU University Hospital, LMU Munich, 81377 Munich, Germany."},{"name":"Department of Neurology, University Hospital Bern, 3010 Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6528-7570","authenticated-orcid":true,"given":"Claudia","family":"Catarino","sequence":"additional","affiliation":[{"name":"Friedrich Baur Institute, Department of Neurology, LMU University Hospital, LMU Munich, 80336 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skadi","family":"Beblo","sequence":"additional","affiliation":[{"name":"Center for Pediatric Research Leipzig, Department of Women and Child Health, Hospital for Children and Adolescents, University Hospital Leipzig; Leipzig University Center for Rare Diseases, 04103 Leipzig, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bergner","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Leipzig, 04103 Leipzig, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurology, LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9544-2279","authenticated-orcid":true,"given":"Michael","family":"Strupp","sequence":"additional","affiliation":[{"name":"Department of Neurology, LMU University Hospital, LMU Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-1265","authenticated-orcid":true,"given":"Gilbert","family":"Di Paolo","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9247-2843","authenticated-orcid":true,"given":"Matthias","family":"Brendel","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."},{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-9559","authenticated-orcid":true,"given":"Sabina","family":"Tahirovic","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-16"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2003.00147.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308456101"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1611956113"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2010.01032.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022575511354"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311591200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2021.11.005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2017.1379610"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000399"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2004.08.011"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-013-9610-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009287"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12380"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag1417"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21428-5"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds324"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070052"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.042"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09796-2"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2009.10.007"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0844-0"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10717-0"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2310151"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.37349\/ent.2021.00012"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5323.232"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(80)90116-2"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227765"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1149"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.06.037"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.12.027"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00345-5"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168858"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22659"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa148"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2022.0388"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.08.006"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-05166-2"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.108048"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp552"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.12.001"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.010"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M040618"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/32440"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/10084"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801463200"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.264171"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.08.012"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02749-2"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom11091361"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00425"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-023-00083-z"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-024-02524-6"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708735200"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-329221"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00616-3"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0900-16.2016"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12715"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.06.014"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01616-0"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.TM118.004165"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12152-2"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e18082"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(97)00099-5"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.189019"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.006"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.026"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.120007"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-216"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40937-z"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep10042"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.05.018"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.05.023"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009290"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.04.006"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00404-0"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.002"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1038"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28395"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-017-3799-9"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.07.009"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2017.12.008"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010079"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606370"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.031591"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107689"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.143"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102266"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.03.042"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021109108"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64604"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23626"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0082-x"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0638-x"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091062498"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-022-09058-7"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00045"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.07.014"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adl4616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T18:59:07Z","timestamp":1733338747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adl4616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,4]]},"references-count":101,"journal-issue":{"issue":"776","published-print":{"date-parts":[[2024,12,4]]}},"alternative-id":["10.1126\/scitranslmed.adl4616"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adl4616","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,4]]},"assertion":[{"value":"2023-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadl4616"}}