{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:36:27Z","timestamp":1792190187510,"version":"4.4.0"},"reference-count":61,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"752","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2024,6,19]]},"abstract":"<jats:p>\n                    The human ileum contains a high density of enteroendocrine L-cells, which release the appetite-suppressing hormones glucagon-like peptide-1 (GLP-1) and peptide tyrosine tyrosine (PYY) in response to food intake. Recent evidence highlighted the potential role of food structures in PYY release, but the link between food structures, ileal metabolites, and appetite hormone release remains unclear owing to limited access to intact human ileum. In a randomized crossover trial (ISRCTN11327221;\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/isrctn.com\">isrctn.com<\/jats:ext-link>\n                    ), we investigated the role of human ileum in GLP-1 and PYY release by giving healthy volunteers diets differing in fiber and food structure: high-fiber (intact or disrupted food structures) or low-fiber disrupted food structures. We used nasoenteric tubes to sample chyme from the intact distal ileum lumina of humans in the fasted state and every 60 min for 480 min postprandially. We demonstrate the highly dynamic, wide-ranging molecular environment of the ileum over time, with a substantial decrease in ileum bacterial numbers and bacterial metabolites after food intake. We also show that high-fiber diets, independent of food structure, increased PYY release compared with a low-fiber diet during 0 to 240 min postprandially. High-fiber diets also increased ileal stachyose, and a disrupted high-fiber diet increased certain ileal amino acids. Treatment of human ileal organoids with ileal fluids or an amino acid and stachyose mixture stimulated\n                    <jats:italic>PYY<\/jats:italic>\n                    expression in a similar profile to blood PYY concentrations, confirming the role of ileal metabolites in PYY release. Our study demonstrates the diet-induced changes over time in the metabolite environment of intact human ileum, which play a role in PYY release.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adm8132","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T13:58:10Z","timestamp":1718805490000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":22,"title":["Diet shapes the metabolite profile in the intact human ileum, which affects PYY release"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3230-3562","authenticated-orcid":true,"given":"Aygul","family":"Dagbasi","sequence":"first","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-6237","authenticated-orcid":true,"given":"Claire","family":"Byrne","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6268-7754","authenticated-orcid":true,"given":"Dominic","family":"Blunt","sequence":"additional","affiliation":[{"name":"Department of Imaging, Charing Cross Hospital, Imperial NHS Trust, London W6 8RF, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8669-7571","authenticated-orcid":true,"given":"Jose Ivan","family":"Serrano-Contreras","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7211-673X","authenticated-orcid":true,"given":"Georgia Franco","family":"Becker","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7725-965X","authenticated-orcid":true,"given":"Jesus Miguens","family":"Blanco","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4614-4662","authenticated-orcid":true,"given":"Stephane","family":"Camuzeaux","sequence":"additional","affiliation":[{"name":"National Phenome Centre, Imperial College London, Hammersmith Hospital Campus, London W12 0HS, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Chambers","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-7971","authenticated-orcid":true,"given":"Nathan","family":"Danckert","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4952-0229","authenticated-orcid":true,"given":"Cathrina","family":"Edwards","sequence":"additional","affiliation":[{"name":"Quadram Institute, Rosalind Franklin Rd, Norwich NR4 7UQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-7225","authenticated-orcid":true,"given":"Andres","family":"Bernal","sequence":"additional","affiliation":[{"name":"Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8433-4275","authenticated-orcid":true,"given":"Maria Valdivia","family":"Garcia","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-737X","authenticated-orcid":true,"given":"Aylin","family":"Hanyaloglu","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Development Biology (IRDB), Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-8389","authenticated-orcid":true,"given":"Elaine","family":"Holmes","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."},{"name":"Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-6078","authenticated-orcid":true,"given":"Yue","family":"Ma","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7994-5239","authenticated-orcid":true,"given":"Julian","family":"Marchesi","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-9672","authenticated-orcid":true,"given":"Laura","family":"Martinez-Gili","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."},{"name":"Section of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8984-0078","authenticated-orcid":true,"given":"Lilian","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3346-7776","authenticated-orcid":true,"given":"Martina","family":"Tashkova","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Perez-Moral","sequence":"additional","affiliation":[{"name":"Quadram Institute, Rosalind Franklin Rd, Norwich NR4 7UQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8398-0603","authenticated-orcid":true,"given":"Isabel","family":"Garcia-Perez","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres Castillo","family":"Robles","sequence":"additional","affiliation":[{"name":"Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-7941","authenticated-orcid":true,"given":"Caroline","family":"Sands","sequence":"additional","affiliation":[{"name":"National Phenome Centre, Imperial College London, Hammersmith Hospital Campus, London W12 0HS, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-2572","authenticated-orcid":true,"given":"Julien","family":"Wist","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."},{"name":"Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia."},{"name":"Chemistry Department, Universidad del Valle, Cali 76001, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3417-0310","authenticated-orcid":true,"given":"Kevin G.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0529-6325","authenticated-orcid":true,"given":"Gary","family":"Frost","sequence":"additional","affiliation":[{"name":"Section of Nutrition, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00456.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232676"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003256"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.05.008"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665120006941"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107833"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.212"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2016.196"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.157248"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3180caa3e3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2016.121"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00130.2013"},{"key":"e_1_3_2_14_2","first-page":"443","article-title":"Bile-acid-mediated decrease in endoplasmic reticulum stress: A potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats","volume":"6","author":"Cummings B. P.","year":"2013","unstructured":"B. P. Cummings, A. Bettaieb, J. L. Graham, J. Kim, F. Ma, N. Shibata, K. L. Stanhope, C. Giulivi, F. Hansen, J. Jelsing, N. Vrang, M. Kowala, M. L. Chouinard, F. G. Haj, P. J. Havel, Bile-acid-mediated decrease in endoplasmic reticulum stress: A potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats. Dis. Model. Mech. 6, 443\u2013456 (2013).","journal-title":"Dis. Model. Mech."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.106203"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.6.977"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43016-020-00159-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12059"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516002610"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2020.106538"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43016-021-00230-y"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11947-020-02436-7"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/193229680900300219"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12681"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2020.00018"},{"key":"e_1_3_2_26_2","first-page":"1229","article-title":"Gastrointestinal motility, part 1: Esophageal transit and gastric emptying","volume":"56","author":"Maurer A. H.","year":"2015","unstructured":"A. H. Maurer, Gastrointestinal motility, part 1: Esophageal transit and gastric emptying. J. Nucl. Med. 56, 1229\u20131238 (2015).","journal-title":"J. Nucl. Med."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00185"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619852255"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13598"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117351"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90436-1"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-020-02439-5"},{"key":"e_1_3_2_33_2","first-page":"210","article-title":"The impact of soluble dietary fibre on gastric emptying, postprandial blood glucose and insulin in patients with type 2 diabetes","volume":"23","author":"Yu K.","year":"2014","unstructured":"K. Yu, M. Y. Ke, W. H. Li, S. Q. Zhang, X. C. Fang, The impact of soluble dietary fibre on gastric emptying, postprandial blood glucose and insulin in patients with type 2 diabetes. Asia Pac. J. Clin. Nutr. 23, 210\u2013218 (2014).","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10030275"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.164"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.223800"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050316"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374378"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529509089791"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17870.2"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30419-3"},{"key":"e_1_3_2_42_2","unstructured":"Public Health England National Diet and Nutrition Survey. Rolling Programme Years 9 to 11 (2016\/2017 to 2018\/2019) (Public Health England 2020); https:\/\/assets.publishing.service.gov.uk\/media\/5fd23324e90e07662b09d91a\/NDNS_UK_Y9-11_report.pdf."},{"issue":"1","key":"e_1_3_2_43_2","first-page":"5","article-title":"Predicting basal metabolic rate, new standards and review of previous work","volume":"39","author":"Schofield W.","year":"1985","unstructured":"W. Schofield, Predicting basal metabolic rate, new standards and review of previous work. Hum. Nutr. Clin. Nutr. 39 (Suppl 1), 5\u201341 (1985).","journal-title":"Hum. Nutr. Clin. Nutr."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.3.312"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91194-9"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90211-2"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2022.115060"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00827-9"},{"key":"e_1_3_2_49_2","unstructured":"Illumina Illumina. 16S Metagenomic Sequencing Library Preparation (2013); https:\/\/support.illumina.com\/downloads\/16s_metagenomic_sequencing_library_preparation.html."},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0605-2"},{"key":"e_1_3_2_53_2","doi-asserted-by":"crossref","unstructured":"K. Schliep A. A. Potts D. A. Morrison G. W. Grimm Intertwining phylogenetic trees and networks. PeerJ 4:e2054v1 [Preprint] (2016); https:\/\/doi.org\/10.7287\/peerj.preprints.2054v1.","DOI":"10.7287\/peerj.preprints.2054v1"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2016-025"},{"key":"e_1_3_2_55_2","unstructured":"J. Oksanen F. G. Blanchet M. Friendly R. Kindt P. Legendre D. McGlinn P. R. Minchin R. B. O'Hara G. L. Simpson P. Solymos M. H. H. Stevens E. Szoecs H. Wagner Vegan: Community Ecology Package (2020); https:\/\/cran.r-project.org\/web\/packages\/vegan\/index.html."},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-12-56"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227285"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac5025039"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0343-3"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13460"},{"key":"e_1_3_2_61_2","doi-asserted-by":"crossref","unstructured":"M. Lewis E. Chekmeneva S. Camuzeaux C. Sands A. Yuen M. David A. Salam K. Chappell B. Cooper G. Haggart L. Maslen M. G\u00f3mez-Romero V. Sluis G. Correia Z. Takats An open platform for large scale LC-MS-based metabolomics ChemRxiv (2022) 10.26434\/chemrxiv-2022-nq9k0.","DOI":"10.26434\/chemrxiv-2022-nq9k0"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(72)90301-6"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adm8132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T13:58:26Z","timestamp":1718805506000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adm8132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,19]]},"references-count":61,"journal-issue":{"issue":"752","published-print":{"date-parts":[[2024,6,19]]}},"alternative-id":["10.1126\/scitranslmed.adm8132"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adm8132","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,19]]},"assertion":[{"value":"2023-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadm8132"}}