{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:40:20Z","timestamp":1791427220267,"version":"4.3.3"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"749","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2024,5,29]]},"abstract":"<jats:p>\n                    Infection with any of the four dengue virus serotypes (DENV1\u20134) can protect against or enhance subsequent dengue depending on preexisting antibodies and infecting serotype. Additionally, primary infection with the related flavivirus Zika virus (ZIKV) is associated with increased risk of DENV2 disease. Here, we measured how prior DENV and ZIKV immunity influenced risk of disease caused by DENV1\u20134 in a pediatric Nicaraguan cohort. Of 3412 participants in 2022, 10.6% experienced dengue cases caused by DENV1 (\n                    <jats:italic>n<\/jats:italic>\n                    = 139), DENV4 (\n                    <jats:italic>n<\/jats:italic>\n                    = 133), DENV3 (\n                    <jats:italic>n<\/jats:italic>\n                    = 54), DENV2 (\n                    <jats:italic>n<\/jats:italic>\n                    = 9), or an undetermined serotype (\n                    <jats:italic>n<\/jats:italic>\n                    = 39). Longitudinal clinical and serological data were used to define infection histories, and generalized linear and additive models adjusted for age, sex, time since last infection, and year, and repeat measurements were used to predict disease risk. Compared with flavivirus-na\u00efve participants, primary ZIKV infection was associated with increased risk of disease caused by DENV4 (relative risk = 2.62, 95% confidence interval: 1.48 to 4.63) and DENV3 (2.90, 1.34 to 6.27), but not DENV1 infection. Primary DENV infection or DENV followed by ZIKV infection was also associated with increased risk of DENV4 disease. We reanalyzed 19 years of cohort data and demonstrated that prior flavivirus immunity and antibody titer had distinct associations with disease risk depending on incoming serotype. We thus find that prior ZIKV infection, like prior DENV infection, is associated with increased risk of disease with certain DENV serotypes. Cross-reactivity among flaviviruses should be considered when assessing vaccine safety and efficacy.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adn2199","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T13:59:08Z","timestamp":1716991148000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":52,"title":["Primary exposure to Zika virus is linked with increased risk of symptomatic dengue virus infection with serotypes 2, 3, and 4, but not 1"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-6173","authenticated-orcid":true,"given":"Jos\u00e9 Victor","family":"Zambrana","sequence":"first","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14006, Nicaragua."},{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3513-562X","authenticated-orcid":true,"given":"Chloe M.","family":"Hasund","sequence":"additional","affiliation":[{"name":"Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4588-4914","authenticated-orcid":true,"given":"Rosemary A.","family":"Aogo","sequence":"additional","affiliation":[{"name":"Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5036-0336","authenticated-orcid":true,"given":"Sandra","family":"Bos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0915-5273","authenticated-orcid":true,"given":"Sonia","family":"Arguello","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14006, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4881-5802","authenticated-orcid":true,"given":"Karla","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14006, Nicaragua."},{"name":"Laboratorio Nacional de Virolog\u00eda, Centro Nacional de Diagn\u00f3stico y Referencia, Ministerio de Salud, Managua 14062, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0878-3260","authenticated-orcid":true,"given":"Damaris","family":"Collado","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14006, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-982X","authenticated-orcid":true,"given":"Tatiana","family":"Miranda","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14006, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-173X","authenticated-orcid":true,"given":"Guillermina","family":"Kuan","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14006, Nicaragua."},{"name":"Centro de Salud S\u00f3crates Flores Vivas, Ministerio de Salud, Managua 12037, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9352-7877","authenticated-orcid":true,"given":"Aubree","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Balmaseda","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua 14006, Nicaragua."},{"name":"Laboratorio Nacional de Virolog\u00eda, Centro Nacional de Diagn\u00f3stico y Referencia, Ministerio de Salud, Managua 14062, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-6758","authenticated-orcid":true,"given":"Leah C.","family":"Katzelnick","sequence":"additional","affiliation":[{"name":"Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-4037","authenticated-orcid":true,"given":"Eva","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.11.026"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax4144"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22401"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053142"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2020.08.006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-8727-1_5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522136113"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44330-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003230"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0337"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113932"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6836"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0157-4"},{"key":"e_1_3_2_15_2","first-page":"311","article-title":"Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered","volume":"42","author":"Halstead S. B.","year":"1970","unstructured":"S. B. Halstead, S. Nimmannitya, S. N. Cohen, Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. Yale J. Biol. Med. 42, 311\u2013328 (1970).","journal-title":"Yale J. Biol. Med."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.1.201"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-013-1645-3"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011710"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb6143"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007766"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10901-1"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.9.793"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75891-z"},{"key":"e_1_3_2_24_2","first-page":"351","article-title":"Dissecting antibodies induced by a chimeric yellow fever-dengue, live-attenuated, tetravalent dengue vaccine (CYD-TDV) in naive and dengue-exposed individuals","volume":"215","author":"Henein S.","year":"2017","unstructured":"S. Henein, J. Swanstrom, A. M. Byers, J. M. Moser, S. F. Shaik, M. Bonaparte, N. Jackson, B. Guy, R. Baric, A. M. de Silva, Dissecting antibodies induced by a chimeric yellow fever-dengue, live-attenuated, tetravalent dengue vaccine (CYD-TDV) in naive and dengue-exposed individuals. J. Infect. Dis. 215, 351\u2013358 (2017).","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2000.63.5"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix609"},{"key":"e_1_3_2_27_2","article-title":"Introduction of new dengue virus lineages after COVID-19 pandemic, Nicaragua, 2022","author":"Cerpas C.","unstructured":"C. Cerpas, G. V\u00e1squez, H. Moreira, J. G. Juarez, J. Coloma, E. Harris, S. N. Bennett, \u00c1. Balmaseda, Introduction of new dengue virus lineages after COVID-19 pandemic, Nicaragua, 2022. Emerg. Infect. Dis., 10.3201\/eid3006.231553, published online 16 May 2024.","journal-title":"Emerg. Infect. Dis"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit273"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abg9478"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12295-2"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104764"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-22231-y"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-1590-z"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.910"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002357"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002462"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09193-y"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154760"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812055115"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01559-15"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01392-9"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.epidem.2022.100630"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit436"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.11-0770"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22402"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620161114"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp092"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1256-6"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804672115"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2207.160326"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.893"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.3.545-551.1992"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.01.007"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002116"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01785-17"},{"key":"e_1_3_2_56_2","first-page":"317","article-title":"Diagnosis of dengue virus infection by detection of specific immunoglobulin M (IgM) and IgA antibodies in serum and saliva","volume":"10","author":"Balmaseda A.","year":"2003","unstructured":"A. Balmaseda, M. G. Guzman, S. Hammond, G. Robleto, C. Flores, Y. Tellez, E. Videa, S. Saborio, L. Perez, E. Sandoval, Y. Rodriguez, E. Harris, Diagnosis of dengue virus infection by detection of specific immunoglobulin M (IgM) and IgA antibodies in serum and saliva. Clin. Diagn. Lab. Immunol. 10, 317\u2013322 (2003).","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002726"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v059.i05"},{"key":"e_1_3_2_59_2","unstructured":"R Core Team R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing 2023)."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1080\/00949655.2016.1149855"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.2307\/2094445"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/rssc.12068"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adn2199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T13:59:22Z","timestamp":1716991162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adn2199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,29]]},"references-count":62,"journal-issue":{"issue":"749","published-print":{"date-parts":[[2024,5,29]]}},"alternative-id":["10.1126\/scitranslmed.adn2199"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adn2199","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.11.29.23299187","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,29]]},"assertion":[{"value":"2023-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadn2199"}}