{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:12:02Z","timestamp":1792102322220,"version":"4.4.0"},"reference-count":55,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"781","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2025,1,15]]},"abstract":"<jats:p>\n                    Dysregulation at the intestinal epithelial barrier is a driver of inflammatory bowel disease (IBD). However, the molecular mechanisms of barrier failure are not well understood. Here, we demonstrate dysregulated mitochondrial fusion in intestinal epithelial cells (IECs) of patients with IBD and show that impaired fusion is sufficient to drive chronic intestinal inflammation. We found reduced expression of mitochondrial fusion\u2013related genes, such as the dynamin-related guanosine triphosphatase (GTPase) optic atrophy 1 (\n                    <jats:italic>OPA1<\/jats:italic>\n                    ), and fragmented mitochondrial networks in crypt IECs of patients with IBD. Mice with\n                    <jats:italic>Opa1<\/jats:italic>\n                    deficiency in the gut epithelium (\n                    <jats:italic>\n                      Opa1\n                      <jats:sup>i\u2206IEC<\/jats:sup>\n                    <\/jats:italic>\n                    ) spontaneously developed chronic intestinal inflammation with mucosal ulcerations and immune cell infiltration. Intestinal inflammation in\n                    <jats:italic>\n                      Opa1\n                      <jats:sup>i\u2206IEC<\/jats:sup>\n                    <\/jats:italic>\n                    mice was driven by microbial translocation and associated with epithelial progenitor cell death and gut barrier dysfunction.\n                    <jats:italic>Opa1<\/jats:italic>\n                    -deficient epithelial cells and human organoids exposed to a pharmacological OPA1 inhibitor showed disruption of the mitochondrial network with mitochondrial fragmentation and changes in mitochondrial size, ultrastructure, and function, resembling changes observed in patient samples. Pharmacological inhibition of the GTPase dynamin-1\u2013like protein in organoids derived from\n                    <jats:italic>\n                      Opa1\n                      <jats:sup>i\u2206IEC<\/jats:sup>\n                    <\/jats:italic>\n                    mice partially reverted this phenotype. Together, our data demonstrate a role for epithelial OPA1 in regulating intestinal immune homeostasis and epithelial barrier function. Our data provide a mechanistic explanation for the observed mitochondrial dysfunction in IBD and identify mitochondrial fusion as a potential therapeutic target in this disease.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adn8699","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T13:58:19Z","timestamp":1736949499000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":35,"title":["Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3081-7062","authenticated-orcid":true,"given":"Li-Li","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Medicine 1, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg (FAU) and Universit\u00e4tsklinikum Erlangen, 91052 Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4847-8877","authenticated-orcid":true,"given":"Yu-Qiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg (FAU) and Universit\u00e4tsklinikum Erlangen, 91052 Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9445-5650","authenticated-orcid":true,"given":"Miguel","family":"Gonz\u00e1lez-Acera","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg (FAU) and Universit\u00e4tsklinikum Erlangen, 91052 Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-7424","authenticated-orcid":true,"given":"Jay V.","family":"Patankar","sequence":"additional","affiliation":[{"name":"Department of 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