{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:27:04Z","timestamp":1789820824108,"version":"4.0.1"},"reference-count":70,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"800","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2025,5,28]]},"abstract":"<jats:p>\n                    Skin-resident regulatory T cells (T\n                    <jats:sub>reg<\/jats:sub>\n                    cells) cells play a critical role in subcutaneous allergen-specific immunotherapy (SIT) for atopic dermatitis (AD). However, a detailed description of the phenotype and origin of skin-resident T\n                    <jats:sub>reg<\/jats:sub>\n                    cells during SIT is lacking. Therefore, we investigated the role and origin of specific T\n                    <jats:sub>reg<\/jats:sub>\n                    lineages in SIT with human AD samples and with a mouse model of AD. In the blood of patients with AD who responded to SIT, T\n                    <jats:sub>reg<\/jats:sub>\n                    cells showed a notable increase in retinoic acid\u2013related orphan receptor \u03b3t (ROR\u03b3t) expression. Moreover, ROR\u03b3t-expressing T\n                    <jats:sub>reg<\/jats:sub>\n                    cells expanded in the skin of patients with AD upon SIT. In a mouse model of AD, the absence of ROR\u03b3t expression in skin T\n                    <jats:sub>reg<\/jats:sub>\n                    cells led to reduced therapeutic efficacy with SIT. In addition, SIT-induced ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>reg<\/jats:sub>\n                    cells originated from peripheral tissue rather than from the thymus. Using two-photon microscopy and a parabiosis mouse model, we observed the migration and accumulation of skin-resident ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>reg<\/jats:sub>\n                    cells in response to the SIT-induced immune response. These findings indicate that SIT induces peripheral ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>reg<\/jats:sub>\n                    cell expansion, which contributes to the therapeutic efficacy of SIT.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.ado1375","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T13:58:31Z","timestamp":1748440711000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Peripherally induced ROR\u03b3t\n                    <sup>+<\/sup>\n                    skin-resident regulatory T cells mediate the efficacy of allergen-specific immunotherapy"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-7373","authenticated-orcid":true,"given":"KeLun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-1605","authenticated-orcid":true,"given":"Su Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3175-0376","authenticated-orcid":true,"given":"Ho-Keun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3720-2509","authenticated-orcid":true,"given":"Seo Hyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-4579","authenticated-orcid":true,"given":"Tae-Gyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhengWang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8574-9464","authenticated-orcid":true,"given":"Hye Li","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1467-6699","authenticated-orcid":true,"given":"Alina","family":"Tyo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2734-1174","authenticated-orcid":true,"given":"Ji Hye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9228-823X","authenticated-orcid":true,"given":"Ryeo Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3385-8180","authenticated-orcid":true,"given":"Jong Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-710X","authenticated-orcid":true,"given":"Je-Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2216-2612","authenticated-orcid":true,"given":"Kyung Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Nano-Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-4470","authenticated-orcid":true,"given":"Lark Kyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-487X","authenticated-orcid":true,"given":"Myung Hyun","family":"Sohn","sequence":"additional","affiliation":[{"name":"Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Won","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Allergy, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-2916","authenticated-orcid":true,"given":"Thomas S.","family":"Kupper","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3856-1201","authenticated-orcid":true,"given":"Chang Ook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea."},{"name":"Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2021.06.002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31861-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1939-4551-7-12"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.10.016"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.10.010"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000216"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.add2563"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.15418"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00786-1"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2014.45"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14257"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8512-5"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.006"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.06.013"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.043"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.03.013"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.13465"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.01.004"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2916"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-2159"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa9420"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00456-w"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0351-z"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.021"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00890-w"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.01.033"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.002"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaw2910"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080034"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-022-00484-0"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23215"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21379"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3883"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72932"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.11.049"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep29015"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11514"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-020-00971-z"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16934"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2016.57.2.393"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa7390"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.049"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.030"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.40"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aao6923"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0674-9"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4263"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00906-5"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05089-y"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05141-x"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05309-5"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.111"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.03.041"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10851"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3860"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010302"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.035"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06878"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903324"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3432"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1774"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.007"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2496"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.078"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.010"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.09.020"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555924447"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2012.4.6.346"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.042"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.438"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.ado1375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T13:58:36Z","timestamp":1748440716000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.ado1375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":70,"journal-issue":{"issue":"800","published-print":{"date-parts":[[2025,5,28]]}},"alternative-id":["10.1126\/scitranslmed.ado1375"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.ado1375","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]},"assertion":[{"value":"2024-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eado1375"}}