{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:01:05Z","timestamp":1793739665963,"version":"4.6.1"},"reference-count":75,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"796","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2025,4,30]]},"abstract":"<jats:p>\n                    Hypersensitivity, phantom percepts, and sensory reactivity are core features of many neurological disorders. Direct, objective measurements of these features have proven difficult to identify, leaving subjective questionnaires as the primary means of assessing sensory disorder severity. Here, we studied neurotypical adults (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a050) or adults with sound sensitivity and tinnitus (ringing of the ears) (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a047) and discovered a previously unidentified set of objective measurements that predicted individual differences in the Tinnitus Handicap Inventory (THI) and Hyperacusis Questionnaire (HQ). A neurophysiological assessment of central auditory gain demonstrated an elevation in participants with tinnitus and sound sensitivity but no association with symptom severity. Instead, accurate predictors of individual THI and HQ scores were identified in pupil dilations and facial movements elicited by emotionally evocative sounds. These findings highlight autonomic signatures of disrupted affective sound processing in persons with tinnitus and sound sensitivity disorders and introduce new approaches for their objective measurement.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adp1934","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T22:02:49Z","timestamp":1746050569000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":21,"title":["Objective autonomic signatures of tinnitus and sound sensitivity disorders"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0991-8224","authenticated-orcid":true,"given":"Samuel S.","family":"Smith","sequence":"first","affiliation":[{"name":"Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA 02114, USA."},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Harvard Medical School, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-5137","authenticated-orcid":true,"given":"Kelly N.","family":"Jahn","sequence":"additional","affiliation":[{"name":"Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA 02114, USA."},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Harvard Medical School, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-4909","authenticated-orcid":true,"given":"Jenna A.","family":"Sugai","sequence":"additional","affiliation":[{"name":"Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5629-498X","authenticated-orcid":true,"given":"Kenneth E.","family":"Hancock","sequence":"additional","affiliation":[{"name":"Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA 02114, USA."},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Harvard Medical School, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5120-2409","authenticated-orcid":true,"given":"Daniel B.","family":"Polley","sequence":"additional","affiliation":[{"name":"Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA 02114, USA."},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Harvard Medical School, Boston, MA 02114, 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M. Bradley P. J. Lang The International Affective Digitized Sounds: Affective Ratings of Sounds and Instruction Manual (Technical Report B-3). University of Florida (NIMH Center for the Study of Emotion and Attention 2007)."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2020.108124"},{"key":"e_1_3_2_49_2","first-page":"233121651881621","article-title":"Attenuation of positive valence in ratings of affective sounds by tinnitus patients","volume":"22","author":"Szibor A.","year":"2018","unstructured":"A. Szibor, J. Lehtim\u00e4ki, J. Ylikoski, A. A. Aarnisalo, A. M\u00e4kitie, P. Hyv\u00e4rinen, Attenuation of positive valence in ratings of affective sounds by tinnitus patients. 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Benedek, C. Kaernbach, Decomposition of skin conductance data by means of nonnegative deconvolution. Psychophysiology 47, 647\u2013658 (2010).","journal-title":"Psychophysiology"},{"key":"e_1_3_2_75_2","unstructured":"C. Lugaresi J. Tang H. Nash C. McClanahan E. Uboweja M. Hays F. Zhang C.-L. Chang M. G. Yong J. 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