{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:17:27Z","timestamp":1792628247670,"version":"4.5.0"},"reference-count":79,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"819","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2025,10,8]]},"abstract":"<jats:p>\n            Upon injury to the mammalian peripheral nervous system (PNS), severed axons undergo rapid SARM1-dependent programmed axon death (Wallerian degeneration), but a potential role for\n            <jats:italic toggle=\"yes\">Sarm1<\/jats:italic>\n            in PNS regeneration remains unclear. We show that in mouse dorsal root ganglia with their axons cut,\n            <jats:italic toggle=\"yes\">Sarm1<\/jats:italic>\n            delayed the activation of injury-induced transcriptional programs associated with axon outgrowth and immune function. After sciatic nerve crush in\n            <jats:italic toggle=\"yes\">\n              Sarm1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n            <\/jats:italic>\n            mice, axons rapidly extended through the nerve injury site, but growth stalled more distally. Slow axon regeneration in the distal nerve was accompanied by delayed induction of the nerve repair response by Schwann cells and delayed clearance of disintegrating myelin. Nerve fibers did regenerate in\n            <jats:italic toggle=\"yes\">\n              Sarm1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n            <\/jats:italic>\n            mice, but regeneration was delayed, and axons exhibited reduced caliber and aberrant target innervation. Tibial nerve action potentials were weaker, and recovery of hind paw function was delayed but ultimately not impaired. Grafting of mouse\n            <jats:italic toggle=\"yes\">\n              Sarm1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n            <\/jats:italic>\n            nerves into wild-type mice and mouse wild-type nerves into\n            <jats:italic toggle=\"yes\">\n              Sarm1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n            <\/jats:italic>\n            mice revealed that the\n            <jats:italic toggle=\"yes\">\n              Sarm1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n            <\/jats:italic>\n            nerve microenvironment was hostile to wild-type axon regeneration and, conversely, that\n            <jats:italic toggle=\"yes\">\n              Sarm1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n            <\/jats:italic>\n            axons robustly grew into mouse wild-type nerve grafts. Ex vivo, the appearance of c-Jun\u2013labeled Schwann cells in cultured mouse\n            <jats:italic toggle=\"yes\">\n              Sarm1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n            <\/jats:italic>\n            nerves was delayed but could be accelerated by pharmacological inhibition of ErbB kinase. Our study highlights the opposing functions of\n            <jats:italic toggle=\"yes\">Sarm1<\/jats:italic>\n            deficiency in dorsal root ganglia and distal nerves in mice, the consequence of which is delayed PNS regeneration.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.adp9155","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:59:46Z","timestamp":1759946386000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Deletion of murine\n            <i>Sarm1<\/i>\n            results in a microenvironment that delays peripheral nerve regeneration after injury"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-6543","authenticated-orcid":true,"given":"Ligia B.","family":"Schmitd","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, 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