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Antibodies targeting the central epitope were broadly cross-reactive, whereas antibodies targeting the lower epitope had narrower breadth but higher potency against H3 subtypes. The ratio of B cells targeting each of the supersites varied with the vaccine subtype, leading to differences in the cross-reactivity of the B cell response. Our findings suggest that vaccine strategies targeting both group 2 stem epitopes would be complementary, eliciting broader and more potent protection against both seasonal and pandemic influenza strains.<\/jats:p>","DOI":"10.1126\/scitranslmed.adr8373","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T18:58:41Z","timestamp":1735757921000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Vaccination with different group 2 influenza subtypes alters epitope targeting and breadth of hemagglutinin stem\u2013specific human B cells"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1925-0851","authenticated-orcid":true,"given":"Grace E.","family":"Mantus","sequence":"first","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20902, 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