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Transl. Med."],"published-print":{"date-parts":[[2025,12,3]]},"abstract":"<jats:p>\n                    Immunoglobulin E (IgE) antibodies play a key role in allergy and its most dangerous and life-threatening manifestation, anaphylaxis. Anti-IgE monoclonal antibodies (mAbs) have been developed to treat IgE-dependent diseases such as allergic asthma, food allergy, and chronic spontaneous urticaria. However, their use is still restricted to a minority of patients suffering from the most severe symptoms because treatment is costly and requires repeated administration. Therefore, we developed a conjugate vaccine against human IgE as a potential alternative therapy for long-term protection from IgE-dependent diseases. The IgE conjugate vaccine was generated by coupling a mutated fragment containing the C\u03b53-4 domains of human IgE with the carrier protein diphtheria cross-reactive material 197 (CRM\n                    <jats:sub>197<\/jats:sub>\n                    ) using kinoid technology to raise autoantibodies against a self-antigen by engrafting it onto the highly immunogenic CRM\n                    <jats:sub>197<\/jats:sub>\n                    carrier. To assess the efficacy of IgE-kinoid (IgE-K) vaccination, we generated a mouse model humanized for IgE and its high-affinity receptor Fc\u03b5RI. IgE-K vaccination induced long-term production of anti\u2013human IgE neutralizing antibodies without any detectable adverse effect. Anti-IgE antibodies were detected in the sera of IgE-K\u2013immunized mice for up to 12 months postvaccination with a similar avidity as the approved anti-IgE mAb omalizumab. Furthermore, IgE-K vaccination protected against both IgE-mediated cutaneous and severe systemic anaphylaxis in IgE\/Fc\u03b5RI-humanized mice. Our results demonstrate that long-term reduction in IgE activity can be achieved through vaccination with human kinoids and can protect against anaphylaxis in humanized mice. This may represent a cost-effective, long-term therapeutic strategy for the treatment of IgE-mediated diseases.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.ads0982","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T18:58:11Z","timestamp":1764788291000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3214-1519","authenticated-orcid":true,"given":"Eva","family":"Conde","sequence":"first","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, France."},{"name":"Neovacs SA, 92150 Suresnes, France."},{"name":"Sorbonne Universit\u00e9, College Doctoral, 75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0987-394X","authenticated-orcid":true,"given":"Emma","family":"Lamanna","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, France."},{"name":"Neovacs SA, 92150 Suresnes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8761-080X","authenticated-orcid":true,"given":"Aur\u00e9lie","family":"Mougel","sequence":"additional","affiliation":[{"name":"Neovacs SA, 92150 Suresnes, France."},{"name":"University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8494-613X","authenticated-orcid":true,"given":"Jasper B. 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