{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:49:30Z","timestamp":1793371770363,"version":"4.5.0"},"reference-count":63,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"778","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2024,12,18]]},"abstract":"<jats:p>The global spread of the highly pathogenic avian influenza (HPAI) A(H5N1) virus poses a serious pandemic threat, necessitating the swift development of effective vaccines. The success of messenger RNA (mRNA) vaccine technology in the COVID-19 pandemic, marked by its rapid development and scalability, demonstrates its potential for addressing other infectious threats, such as HPAI A(H5N1). We therefore evaluated mRNA vaccine candidates targeting panzootic influenza A(H5) clade 2.3.4.4b viruses, which have been shown to infect a range of mammalian species, including most recently being detected in dairy cattle. Ferrets were immunized with mRNA vaccines encoding either hemagglutinin alone or hemagglutinin and neuraminidase, derived from a 2.3.4.4b prototype vaccine virus recommended by the World Health Organization. Kinetics of the immune responses, as well as protection against a lethal challenge dose of A(H5N1) virus, were assessed. Two doses of mRNA vaccination elicited robust neutralizing antibody titers against a 2022 avian isolate and a 2024 human isolate. Further, mRNA vaccination conferred protection from lethal challenge, whereas all unvaccinated ferrets succumbed to infection. It also reduced viral titers in the upper and lower respiratory tracts of infected ferrets. These results underscore the effectiveness of mRNA vaccines against HPAI A(H5N1), showcasing their potential as a vaccine platform for future influenza pandemics.<\/jats:p>","DOI":"10.1126\/scitranslmed.ads1273","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T19:00:17Z","timestamp":1734548417000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":43,"title":["An influenza mRNA vaccine protects ferrets from lethal infection with highly pathogenic avian influenza A(H5N1) virus"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5532-2942","authenticated-orcid":true,"given":"Masato","family":"Hatta","sequence":"first","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1024-3792","authenticated-orcid":true,"given":"Yasuko","family":"Hatta","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4131-2292","authenticated-orcid":true,"given":"Angela","family":"Choi","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaber","family":"Hossain","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Feng","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-1698","authenticated-orcid":true,"given":"Matthew W.","family":"Keller","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4768-162X","authenticated-orcid":true,"given":"Jana M.","family":"Ritter","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-5301","authenticated-orcid":true,"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Fang","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."},{"name":"Decatur High School, Decatur, GA 30030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8193-710X","authenticated-orcid":true,"given":"Elizabeth A.","family":"Pusch","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-3280","authenticated-orcid":true,"given":"Thomas","family":"Rowe","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-065X","authenticated-orcid":true,"given":"Juan A.","family":"De La Cruz","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0226-5183","authenticated-orcid":true,"given":"Jimma","family":"Liddell","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3375-4805","authenticated-orcid":true,"given":"Nannan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6792-7650","authenticated-orcid":true,"given":"Daniel","family":"Stadlbauer","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9252-7107","authenticated-orcid":true,"given":"Arindam K.","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-904X","authenticated-orcid":true,"given":"Joseph R.","family":"Rouse","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Currier","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-5986","authenticated-orcid":true,"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3197-1649","authenticated-orcid":true,"given":"Min Z.","family":"Levine","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0859-9604","authenticated-orcid":true,"given":"Marie K.","family":"Kirby","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1217-0990","authenticated-orcid":true,"given":"John","family":"Steel","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0672-1497","authenticated-orcid":true,"given":"Han","family":"Di","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Henry","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Todd","family":"Davis","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5568-5420","authenticated-orcid":true,"given":"Raffael","family":"Nachbagauer","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Wentworth","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1535-6283","authenticated-orcid":true,"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/338820"},{"key":"e_1_3_2_3_2","unstructured":"World Health Organization Regional Office for the Western Pacific \u201cHuman infection with avian influenza A(H5) viruses \u201d Avian Influenza Wkly. Update (no. 931) (26 January 2024)."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-022-05442-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/v13050886"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2805.220318"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-01338-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00110-06"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq7228"},{"key":"e_1_3_2_10_2","unstructured":"US Department of Agriculture Animal and Plant Health Inspection Service 2022\u20132024 Confirmations of highly pathogenic avian influenza in commercial and backyard flocks (20 June 2024); www.aphis.usda.gov\/aphis\/ourfocus\/animalhealth\/animal-disease-information\/avian\/avian-influenza\/hpai-2022\/2022-hpai-commercial-backyard-flocks."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2912.230464"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41182-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2904.221538"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2023.28.3.2300001"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2023.28.31.2300366"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2908.230188"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid3007.240508"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"X. Hu A. Saxena D. R. Magstadt P. C. Gauger E. Burrough J. Zhang C. Siepker M. Mainenti P. J. Gorden P. Plummer G. Li Highly pathogenic avian influenza A (H5N1) clade 2.3.4.4b virus detected in dairy cattle. bioRxiv 588916 [Preprint] (2024). https:\/\/doi.org\/10.1101\/2024.04.16.588916.","DOI":"10.1101\/2024.04.16.588916"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","unstructured":"T.-Q. Nguyen C. Hutter A. Markin M. Thomas K. Lantz M. L. Killian G. M. Janzen S. Vijendran S. Wagle B. Inderski D. R. Magstadt G. Li D. G. Diel E. A. Frye K. M. Dimitrov A. K. Swinford A. C. Thompson K. R. Snevik D. L. Suarez E. Spackman S. M. Lakin S. C. Ahola K. R. Johnson A. L. Baker S. Robbe-Austerman M. K. Torchetti T. K. Anderson Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle. bioRxiv 591751 [Preprint] (2024). https:\/\/doi.org\/10.1101\/2024.05.01.591751.","DOI":"10.1101\/2024.05.01.591751"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2023.2186608"},{"key":"e_1_3_2_21_2","unstructured":"US Food and Drug Administration Influenza virus vaccine H5N1 (for national stockpile) (2018); www.fda.gov\/vaccines-blood-biologics\/vaccines\/influenza-virus-vaccine-h5n1-national-stockpile."},{"key":"e_1_3_2_22_2","unstructured":"US Food and Drug Administration AUDENZ Influenza A (H5N1) monovalent vaccine adjuvanted (2021); www.fda.gov\/vaccines-blood-biologics\/audenz."},{"key":"e_1_3_2_23_2","unstructured":"US Food and Drug Administration Influenza A (H5N1) virus monovalent vaccine adjuvanted (2019); www.fda.gov\/vaccines-blood-biologics\/vaccines\/influenza-h5n1-virus-monovalent-vaccine-adjuvanted."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-017-0017-5"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05066-2"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00632-1"},{"key":"e_1_3_2_27_2","unstructured":"World Health Organization Zoonotic influenza: Candidate vaccine viruses and potency testing reagents (2024); www.who.int\/teams\/global-influenza-programme\/vaccines\/who-recommendations\/zoonotic-influenza-viruses-and-candidate-vaccine-viruses."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.03.043"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.243"},{"key":"e_1_3_2_30_2","unstructured":"ModernaTX Inc. A study of mRNA-1010 seasonal influenza vaccine in adults (clinicaltrials.gov 2022); https:\/\/clinicaltrials.gov\/study\/NCT05827978?rank=1."},{"key":"e_1_3_2_31_2","unstructured":"Pfizer A study to evaluate a modified RNA vaccine against influenza in adults 18 years of age or older (clinicaltrials.gov 2022); https:\/\/clinicaltrials.gov\/study\/NCT05827926."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-023-00752-5"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39376-7"},{"key":"e_1_3_2_34_2","unstructured":"ModernaTX Inc. A study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) multi-component vaccines in healthy adults (clinicaltrials.gov 2023); https:\/\/clinicaltrials.gov\/study\/NCT05827926."},{"key":"e_1_3_2_35_2","unstructured":"Pfizer A study to evaluate a modified RNA vaccine against influenza in adults 18 years of age or older (clinicaltrials.gov 2022); www.clinicaltrials.gov\/study\/NCT05540522?term=NCT05540522&rank=1&tab=history."},{"key":"e_1_3_2_36_2","unstructured":"BioNTech SE A study to evaluate the safety tolerability and immunogenicity of combined modified RNA vaccine candidates against COVID-19 and influenza (clinicaltrials.gov 2022); www.clinicaltrials.gov\/study\/NCT05596734?term=NCT05596734&rank=1&tab=history."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38415-7"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2436"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05482-0"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.04.018"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2021.06.003"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00420-6"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2206333119"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32149-8"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2023.2256422"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2023.2202278"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01723-22"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm0271"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adc9937"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2022.09.013"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48555-z"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68656-X"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055778"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00395-9"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00390-9"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00241-09"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08054-z"},{"key":"e_1_3_2_58_2","unstructured":"World Health Organization \u201cWHO manual on animal influenza diagnosis and surveillance\u201d (WHO\/CDS\/CSR\/NCS\/2002.5 WHO 2002); https:\/\/iris.who.int\/handle\/10665\/68026."},{"key":"e_1_3_2_59_2","first-page":"15G.1.1","article-title":"Influenza: Propagation, quantification, and storage","volume":"29","author":"Balish A. L.","year":"2013","unstructured":"A. L. Balish, J. M. Katz, A. I. Klimov, Influenza: Propagation, quantification, and storage. Curr. Protoc. Microbiol. 29, 15G.1.1\u201315G.1.24 (2013).","journal-title":"Curr. Protoc. Microbiol."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz6893"},{"key":"e_1_3_2_61_2","unstructured":"L. C. Chosewood D. E. Wilson US Centers for Disease Control and Prevention US National Institutes of Health Biosafety in Microbiological and Biomedical Laboratories (HHS Publications US Department of Health and Human Services Public Health Service Centers for Disease Control and Prevention National Institutes of Health ed. 5 2009) pp. xxii\u2013415."},{"key":"e_1_3_2_62_2","unstructured":"World Health Organization \u201cSummary of status of development and availability of A(H5N1) candidate vaccine viruses and potency testing reagents\u201d (WHO 23 February 2024)."},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-024-00973-2"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200761"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.ads1273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T19:00:39Z","timestamp":1734548439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.ads1273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":63,"journal-issue":{"issue":"778","published-print":{"date-parts":[[2024,12,18]]}},"alternative-id":["10.1126\/scitranslmed.ads1273"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.ads1273","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"2024-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eads1273"}}