{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:21:27Z","timestamp":1788448887935,"version":"build-2803163510"},"reference-count":45,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"793","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.science.org\/content\/page\/science-licenses-journal-article-reuse"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2025,4,9]]},"abstract":"<jats:p>\n            Kidney fibrosis determines clinical outcomes in individuals with chronic kidney disease (CKD). The stoichiometric ratio of collagens in renal scar differs from that of healthy kidney extracellular matrix (ECM), but the functional importance of altered collagen types in injured kidneys remains unclear. Using human population studies, we show that circulating protein and renal mRNA amounts of collagen V A1 (COL5A1) exhibited associations with kidney disease and incident CKD risk. We show that\n            <jats:italic>Col5a1<\/jats:italic>\n            regulates the degree of postinjury fibrosis and renal function. Mice with conditionally knocked out\n            <jats:italic>Col5a1<\/jats:italic>\n            (\n            <jats:italic>Col5a1<\/jats:italic>\n            CKO) exhibited decreased renal function and greater renal fibrosis after dietary adenine- or ureteric obstruction\u2013mediated kidney injury. Renal fibroblasts in\n            <jats:italic>Col5a1<\/jats:italic>\n            CKO animals up-regulated the profibrotic \u03b1v\u03b23 integrin. Inhibition of \u03b1v\u03b23 signaling with a small molecule, cilengitide, rescued postinjury renal function in\n            <jats:italic>Col5a1<\/jats:italic>\n            CKO animals. Using the hybrid mouse diversity panel that comprises 100 diverse inbred strains of mice, we observed that gene expression of\n            <jats:italic>Col5a1<\/jats:italic>\n            after injury exhibited genetic variation across 100 strains. Strains with low\n            <jats:italic>Col5a1<\/jats:italic>\n            expression after injury exhibited worse renal function compared with animals that had higher degrees of expression. We next measured\n            <jats:italic>Col5a1<\/jats:italic>\n            expression in peripheral blood mononuclear cells in mice to identify nonresponder strains that did not have increased\n            <jats:italic>Col5a1<\/jats:italic>\n            expression after kidney injury. We observed that administration of cilengitide in nonresponder strains significantly rescued postinjury renal fibrosis and function. These studies point to the feasibility of precision medicine approaches to target\n            <jats:italic>Col5a1<\/jats:italic>\n            for enhancing renal repair.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.ads7714","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T18:00:46Z","timestamp":1744221646000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":10,"title":["Collagen V regulates renal function after kidney injury and can be pharmacologically targeted to enhance kidney repair in mice"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6822-6602","authenticated-orcid":true,"given":"Lianjiu","family":"Su","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"UCLA Cardiovascular Theme, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5508-5561","authenticated-orcid":true,"given":"Qihao","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"UCLA Cardiovascular Theme, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2935-5944","authenticated-orcid":true,"given":"Yusheng","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"UCLA Cardiovascular Theme, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0681-9482","authenticated-orcid":true,"given":"Juan Felipe","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"UCLA Cardiovascular Theme, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Tao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"UCLA Cardiovascular Theme, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9131-6278","authenticated-orcid":true,"given":"Yiqian","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Hanudel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-4209","authenticated-orcid":true,"given":"Alejandro","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"UCLA Cardiovascular Theme, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0752-833X","authenticated-orcid":true,"given":"Calvin","family":"Pan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5849-7839","authenticated-orcid":true,"given":"James R.","family":"Hilser","sequence":"additional","affiliation":[{"name":"Departments of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA."},{"name":"Departments of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-9318","authenticated-orcid":true,"given":"Jaana A.","family":"Hartiala","sequence":"additional","affiliation":[{"name":"Departments of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA."},{"name":"Departments of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8114-1136","authenticated-orcid":true,"given":"Shen","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"UCLA Cardiovascular Theme, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-9564","authenticated-orcid":true,"given":"Matteo","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2384-5239","authenticated-orcid":true,"given":"Hooman","family":"Allayee","sequence":"additional","affiliation":[{"name":"Departments of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA."},{"name":"Departments of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-0228","authenticated-orcid":true,"given":"Aldons J.","family":"Lusis","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0978-2611","authenticated-orcid":true,"given":"Arjun","family":"Deb","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"UCLA Cardiovascular Theme, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1369\/0022155419849388"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2021.11.003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"100438","DOI":"10.1016\/j.lanepe.2022.100438","article-title":"Prevalence, outcomes, and cost of chronic kidney disease in a contemporary population of 2\u00b74 million patients from 11 countries: The CaReMe CKD study","volume":"20","author":"Sundstr\u00f6m J.","year":"2022","unstructured":"J. Sundstr\u00f6m, J. Bodegard, A. Bollmann, M. G. Vervloet, P. B. Mark, A. Karasik, T. Taveira-Gomes, M. Botana, K. I. Birkeland, M. Thuresson, L. J\u00e4ger, M. M. Sood, G. Van Pottelbergh, N. Tangri, CaReMe CKD Investigators, Prevalence, outcomes, and cost of chronic kidney disease in a contemporary population of 2\u00b74 million patients from 11 countries: The CaReMe CKD study. Lancet Reg. Health Eur. 20, 100438 (2022).","journal-title":"Lancet Reg. Health Eur."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1001\/jama.2019.14745","article-title":"Chronic kidney disease diagnosis and management: A review","volume":"322","author":"Chen T. K.","year":"2019","unstructured":"T. K. Chen, D. H. Knicely, M. E. Grams, Chronic kidney disease diagnosis and management: A review. JAMA 322, 1294\u20131304 (2019).","journal-title":"JAMA"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00590-z"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3389\/fphar.2017.00520","article-title":"Progression of tubulointerstitial fibrosis and the chronic kidney disease phenotype \u2013 Role of risk factors and epigenetics","volume":"8","author":"Hewitson T. D.","year":"2017","unstructured":"T. D. Hewitson, S. G. Holt, E. R. Smith, Progression of tubulointerstitial fibrosis and the chronic kidney disease phenotype \u2013 Role of risk factors and epigenetics. Front. Pharmacol. 8, 520 (2017).","journal-title":"Front. Pharmacol."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034227"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1300575"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-4328(00)00043-3"},{"key":"e_1_3_2_11_2","first-page":"211","article-title":"Progression of chronic renal disease in humans is associated with the deposition of basement membrane components and decorin in the interstitial extracellular matrix","volume":"44","author":"Vleming L. J.","year":"1995","unstructured":"L. J. Vleming, J. J. Baelde, R. G. Westendorp, M. R. Daha, L. A. van Es, J. A. Bruijn, Progression of chronic renal disease in humans is associated with the deposition of basement membrane components and decorin in the interstitial extracellular matrix. Clin. Nephrol. 44, 211\u2013219 (1995).","journal-title":"Clin. Nephrol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.091363"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409622200"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.030"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.vascn.2013.05.006","article-title":"Adenine-induced chronic kidney and cardiovascular damage in rats","volume":"68","author":"Diwan V.","year":"2013","unstructured":"V. Diwan, A. Mistry, G. Gobe, L. Brown, Adenine-induced chronic kidney and cardiovascular damage in rats. J. Pharmacol. Toxicol. Methods 68, 197\u2013207 (2013).","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"e0192531","DOI":"10.1371\/journal.pone.0192531","article-title":"A novel approach to adenine-induced chronic kidney disease associated anemia in rodents","volume":"13","author":"Rahman A.","year":"2018","unstructured":"A. Rahman, D. Yamazaki, A. Sufiun, K. Kitada, H. Hitomi, D. Nakano, A. Nishiyama, A novel approach to adenine-induced chronic kidney disease associated anemia in rodents. PLOS ONE 13, e0192531 (2018).","journal-title":"PLOS ONE"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/biom9040141","article-title":"Unilateral ureteral obstruction as a model to investigate fibrosis-attenuating treatments","volume":"9","author":"Mart\u00ednez-Klimova E.","year":"2019","unstructured":"E. Mart\u00ednez-Klimova, O. E. Aparicio-Trejo, E. Tapia, J. Pedraza-Chaverri, Unilateral ureteral obstruction as a model to investigate fibrosis-attenuating treatments. Biomolecules 9, 141 (2019).","journal-title":"Biomolecules"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06592-6"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.155697.113"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013451"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1181"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315863"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2016.10.016"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.02.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0132-x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1161\/CIRCGENETICS.113.000732","article-title":"Mapping genetic contributions to cardiac pathology induced by beta-adrenergic stimulation in mice","volume":"8","author":"Rau C. D.","year":"2015","unstructured":"C. D. Rau, J. Wang, R. Avetisyan, M. Romay, L. Martin, S. Ren, Y. Wang, A. J. Lusis, Mapping genetic contributions to cardiac pathology induced by beta-adrenergic stimulation in mice. Circ. Cardiovasc. Genet. 8, 40\u201349 (2015).","journal-title":"Circ. Cardiovasc. Genet."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3282"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20171426"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.8.1225"},{"key":"e_1_3_2_30_2","first-page":"4213","article-title":"Integrin inhibitor cilengitide for the treatment of glioblastoma: A brief overview of current clinical results","volume":"32","author":"Scaringi C.","year":"2012","unstructured":"C. Scaringi, G. Minniti, P. Caporello, R. M. Enrici, Integrin inhibitor cilengitide for the treatment of glioblastoma: A brief overview of current clinical results. Anticancer Res. 32, 4213\u20134223 (2012).","journal-title":"Anticancer Res."},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1200\/jco.2012.30.15_suppl.2055","article-title":"Effect of the integrin inhibitor cilengitide on TGF-beta signaling","volume":"30","author":"Weller M.","year":"2012","unstructured":"M. Weller, M. Silginer, S. L. Goodman, K. Hasenbach, S. Thies, P. Schraml, G. Tabatabai, H. Moch, I. Tritschler, P. Roth, Effect of the integrin inhibitor cilengitide on TGF-beta signaling. J. Clin. Oncol. 30, 2055\u20132055 (2012).","journal-title":"J. Clin. Oncol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4253"},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"l4966","DOI":"10.1136\/bmj.l4966","article-title":"Ehlers-Danlos syndromes","volume":"366","author":"Ghali N.","year":"2019","unstructured":"N. Ghali, G. Sobey, N. Burrows, Ehlers-Danlos syndromes. BMJ 366, l4966 (2019).","journal-title":"BMJ"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1086\/302930","article-title":"COL5A1 haploinsufficiency is a common molecular mechanism underlying the classical form of EDS","volume":"66","author":"Wenstrup R. J.","year":"2000","unstructured":"R. J. Wenstrup, J. B. Florer, M. C. Willing, C. Giunta, B. Steinmann, F. Young, M. Susic, W. G. Cole, COL5A1 haploinsufficiency is a common molecular mechanism underlying the classical form of EDS. Am. J. Hum. Genet. 66, 1766\u20131776 (2000).","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/GIM.0b013e3181eed412","article-title":"Clinical and genetic aspects of Ehlers-Danlos syndrome, classic type","volume":"12","author":"Malfait F.","year":"2010","unstructured":"F. Malfait, R. J. Wenstrup, A. De Paepe, Clinical and genetic aspects of Ehlers-Danlos syndrome, classic type. Genet. Med. 12, 597\u2013605 (2010).","journal-title":"Genet. Med."},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12964-024-01646-2","article-title":"Integrin-linked kinase mRNA expression in circulating mononuclear cells as a biomarker of kidney and vascular damage in experimental chronic kidney disease","volume":"22","author":"Campillo S.","year":"2024","unstructured":"S. Campillo, E. Guti\u00e9rrez-Calabr\u00e9s, S. Garc\u00eda-Miranda, M. Griera, L. Fern\u00e1ndez Rodr\u00edguez, S. de Frutos, D. Rodr\u00edguez-Puyol, L. Calleros, Integrin-linked kinase mRNA expression in circulating mononuclear cells as a biomarker of kidney and vascular damage in experimental chronic kidney disease. Cell Commun. Signal 22, 264 (2024).","journal-title":"Cell Commun. Signal"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61108-X"},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.bbadis.2019.01.024","article-title":"Chronic kidney disease induced by an adenine rich diet upregulates integrin linked kinase (ILK) and its depletion prevents the disease progression","volume":"1865","author":"de Frutos S.","year":"2019","unstructured":"S. de Frutos, A. Luengo, A. Garc\u00eda-J\u00e9rez, M. Hatem-Vaquero, M. Griera, F. O\u2019Valle, M. Rodr\u00edguez-Puyol, D. Rodr\u00edguez-Puyol, L. Calleros, Chronic kidney disease induced by an adenine rich diet upregulates integrin linked kinase (ILK) and its depletion prevents the disease progression. Biochim. Biophys. Acta Mol. Basis Dis. 1865, 1284\u20131297 (2019).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09329-0"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.08.003"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1161\/01.RES.70.5.1006","article-title":"Isolation, characterization, and localization of cardiac collagen type VI. Associations with other extracellular matrix components","volume":"70","author":"Bashey R. I.","year":"1992","unstructured":"R. I. Bashey, A. Martinez-Hernandez, S. A. Jimenez, Isolation, characterization, and localization of cardiac collagen type VI. Associations with other extracellular matrix components. Circ. Res. 70, 1006\u20131017 (1992).","journal-title":"Circ. Res."},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2006.03.008"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4197"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_46_2","first-page":"100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu T.","year":"2021","unstructured":"T. Wu, E. Hu, S. Xu, M. Chen, P. Guo, Z. Dai, T. Feng, L. Zhou, W. Tang, L. Zhan, X. Fu, S. Liu, X. Bo, G. Yu, clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innovation 2, 100141 (2021).","journal-title":"Innovation"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.ads7714","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.ads7714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T18:01:06Z","timestamp":1744221666000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.ads7714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":45,"journal-issue":{"issue":"793","published-print":{"date-parts":[[2025,4,9]]}},"alternative-id":["10.1126\/scitranslmed.ads7714"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.ads7714","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"assertion":[{"value":"2024-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eads7714"}}