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In patients with SLE, aging correlated with lower expression of interferon (IFN)\u2013stimulated genes (ISGs) across multiple cell types, decreased plasma IFN-\u03b12, and differential genome methylation. Both patients with SLE and controls demonstrated age-related declines in na\u00efve T cells, but only patients with SLE exhibited increases in CD56\n                    <jats:sup>dim<\/jats:sup>\n                    natural killer cells with older age. Of the genes both down-regulated and hypermethylated with older age, ISGs were disproportionately represented, suggesting a role for epigenetic silencing. Altogether, we found that patients with SLE exhibit unique aging-related decreases in IFN signaling that correlate with improved disease activity.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adt5550","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T13:58:38Z","timestamp":1750859918000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":10,"title":["Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1292-1336","authenticated-orcid":true,"given":"Rithwik","family":"Narendra","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"University of California, Los Angeles, Los Angeles, CA 90095, 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