{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:23:57Z","timestamp":1780964637380,"version":"3.54.1"},"reference-count":86,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"826","funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["101160061"],"award-info":[{"award-number":["101160061"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P-37275"],"award-info":[{"award-number":["P-37275"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["70114478"],"award-info":[{"award-number":["70114478"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Research Council","award":["I6944"],"award-info":[{"award-number":["I6944"]}]},{"name":"European Research Council","award":["682473"],"award-info":[{"award-number":["682473"]}]},{"name":"European Research Council","award":["682473"],"award-info":[{"award-number":["682473"]}]},{"DOI":"10.13039\/501100005677","name":"DJCLS","doi-asserted-by":"crossref","award":["16 R\/2021"],"award-info":[{"award-number":["16 R\/2021"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Horizon 2020 research and innovation program","award":["638035"],"award-info":[{"award-number":["638035"]}]},{"name":"SFB 1335","award":["360372040"],"award-info":[{"award-number":["360372040"]}]},{"name":"EU4H","award":["101161236"],"award-info":[{"award-number":["101161236"]}]},{"name":"DFG Emmy Noether Grant","award":["JA 3274\/1-1"],"award-info":[{"award-number":["JA 3274\/1-1"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:p>\n                    Acute myeloid leukemia (AML) is characterized by frequent relapse, which is driven by resistant leukemic stem or progenitor cells (LSCs). Here, we reported on a tumor-suppressive mechanism that can be harnessed to simultaneously clear LSCs and promote healthy hematopoiesis. Genetic deletion of the tumor necrosis factor (TNF) superfamily member\n                    <jats:italic toggle=\"yes\">lymphotoxin alpha<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">Lta<\/jats:italic>\n                    ) blocked cell death and accelerated leukemogenesis in murine AML models. Accordingly, exposure of leukemic cells to exogenous recombinant lymphotoxin alpha (LT\u03b1\n                    <jats:sub>3<\/jats:sub>\n                    ) induced myeloid differentiation and, in part, cell death in AML progenitors. In syngeneic and patient-derived xenograft mouse models, exposure to recombinant LT\u03b1\n                    <jats:sub>3<\/jats:sub>\n                    resulted in deep and durable remissions. LT\u03b1\n                    <jats:sub>3<\/jats:sub>\n                    repressed leukemia by depleting tumor necrosis factor receptor (TNFR)\u2013associated factor 2 (TRAF2) through activation of TNF receptors TNFR1 and TNFR2. In contrast with conventional therapies, LT\u03b1\n                    <jats:sub>3<\/jats:sub>\n                    exerted only minimal toxicity on the healthy hematopoiesis but instead promoted hematopoietic progenitors. Leveraging this endogenous tumor-suppressive mechanism may decouple treatment efficacy on malignant cells from undesired bone marrow suppression.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adu3313","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T18:58:16Z","timestamp":1764183496000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-3343","authenticated-orcid":true,"given":"Ulrike","family":"H\u00f6ckendorf","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, M\u00fcnchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-9509","authenticated-orcid":true,"given":"Sayantanee","family":"Dutta","sequence":"additional","affiliation":[{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4187-2513","authenticated-orcid":true,"given":"Arnold","family":"Kloos","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9059-9269","authenticated-orcid":true,"given":"Marah","family":"Runtsch","sequence":"additional","affiliation":[{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."},{"name":"Cycuria Therapeutics, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9228-210X","authenticated-orcid":true,"given":"Carina","family":"Z\u00f6tsch","sequence":"additional","affiliation":[{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."},{"name":"Cycuria Therapeutics, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-1483","authenticated-orcid":true,"given":"Sebastian","family":"Vosberg","sequence":"additional","affiliation":[{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7035-5382","authenticated-orcid":true,"given":"Yongjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Proteomics and Cancer Cell Signaling, DKFZ and Hopp Children\u2019s Cancer Center (KiTZ), Heidelberg, Germany and Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9871-6983","authenticated-orcid":true,"given":"Sophie","family":"Kienreich","sequence":"additional","affiliation":[{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0271-6832","authenticated-orcid":true,"given":"Bettina","family":"Flasch","sequence":"additional","affiliation":[{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Malovan","sequence":"additional","affiliation":[{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7761-3606","authenticated-orcid":true,"given":"Vanessa","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5858-4067","authenticated-orcid":true,"given":"Stefanie","family":"Stanzer","sequence":"additional","affiliation":[{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Prein","sequence":"additional","affiliation":[{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-4582","authenticated-orcid":true,"given":"Timo O.","family":"Odinius","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, M\u00fcnchen, Germany."},{"name":"Department of Medical Oncology and Hematology, University Hospital Z\u00fcrich, Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8312-3617","authenticated-orcid":true,"given":"Celina V.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, M\u00fcnchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-816X","authenticated-orcid":true,"given":"Lars","family":"Buschhorn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, M\u00fcnchen, Germany."},{"name":"National Center for Tumor Diseases (NCT) Heidelberg, University Hospital and German Cancer Research Center (DKFZ), Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4258-4986","authenticated-orcid":true,"given":"Veronika","family":"Dill","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, M\u00fcnchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2302-301X","authenticated-orcid":true,"given":"Bianca","family":"Perfler","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."},{"name":"Division of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0196-2837","authenticated-orcid":true,"given":"Torsten","family":"Haferlach","sequence":"additional","affiliation":[{"name":"Munich Leukemia Laboratory (MLL), Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstanze","family":"D\u00f6hner","sequence":"additional","affiliation":[{"name":"Ulm University Hospital, Department of Internal Medicine III, Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-8002","authenticated-orcid":true,"given":"Katharina S.","family":"G\u00f6tze","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, M\u00fcnchen, Germany."},{"name":"German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and TUM University Hospital, Munich, Germany."},{"name":"Bavarian Cancer Research Center (BZKF), Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8381-3597","authenticated-orcid":true,"given":"J\u00fcrgen","family":"Ruland","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and TUM University Hospital, Munich, Germany."},{"name":"Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University of Munich, Munich, Germany."},{"name":"TranslaTUM, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4435-2609","authenticated-orcid":true,"given":"Florian","family":"Bassermann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, M\u00fcnchen, Germany."},{"name":"German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and TUM University Hospital, Munich, Germany."},{"name":"Bavarian Cancer Research Center (BZKF), Munich, Germany."},{"name":"TranslaTUM, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-8834","authenticated-orcid":true,"given":"Adam","family":"Wahida","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Cell Death, Helmholtz Centre Munich, Neuherberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3135-2274","authenticated-orcid":true,"given":"Mathias","family":"Heikenw\u00e4lder","sequence":"additional","affiliation":[{"name":"Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6231-2040","authenticated-orcid":true,"given":"Caterina","family":"Branca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, M\u00fcnchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8461-8881","authenticated-orcid":true,"given":"Johannes","family":"Schm\u00f6llerl","sequence":"additional","affiliation":[{"name":"Research Institute of Molecular Pathology, Vienna BioCenter (VBC), Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8810-6835","authenticated-orcid":true,"given":"Johannes","family":"Zuber","sequence":"additional","affiliation":[{"name":"Research Institute of Molecular Pathology, Vienna BioCenter (VBC), Vienna, Austria."},{"name":"Medical University of Vienna, Vienna BioCenter (VBC), Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1282-2680","authenticated-orcid":true,"given":"Ann-Cathrin","family":"Burk","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6565-3393","authenticated-orcid":true,"given":"Robert","family":"Zeiser","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-4371","authenticated-orcid":true,"given":"Heinz","family":"Sill","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-1117","authenticated-orcid":true,"given":"Ashok Kumar","family":"Jayavelu","sequence":"additional","affiliation":[{"name":"Proteomics and Cancer Cell Signaling, DKFZ and Hopp Children\u2019s Cancer Center (KiTZ), Heidelberg, Germany and Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-7021","authenticated-orcid":true,"given":"Armin","family":"Zebisch","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."},{"name":"Division of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Heuser","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany."},{"name":"Department of Internal Medicine IV, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1693-1761","authenticated-orcid":true,"given":"Michael A.","family":"Dengler","sequence":"additional","affiliation":[{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-0362","authenticated-orcid":true,"given":"Philipp J.","family":"Jost","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, M\u00fcnchen, Germany."},{"name":"Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria."},{"name":"BioTechMed, Graz and Austrian Comprehensive Cancer Network (ACCN), Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.025"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406184"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc989"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13038"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.280800"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00509-w"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201541"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz0463"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.06.002"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023105"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0245-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.05.019"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110752"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.002"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130990"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.12.4487"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.12.2292.2292"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00792-3"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.08.002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.037"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14191"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12984"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141007"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.01.007"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-570762"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3660"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000201"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/2191076a0"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.02.001"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(89)90001-5"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80455-0"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115719"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8171323"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90574-A"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03633-8"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)01995-8"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90192-2"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06458-11"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3406"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8171322"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400059"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00931-3"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.04.001"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.02.006"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.4.745"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01751-05"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.49"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.448"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.1.310"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI154993"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.5320"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaj2025"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-3186"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010222"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.20.9292"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90532-0"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1267837"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.13.2757"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/416345a"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.037341"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140131"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2208"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0956"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0194-4"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba9304"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.06.073"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.072256"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-225680"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg128"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.12.1942"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.11.2205"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.3.298"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686489"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-016-0846-5"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30845"},{"key":"e_1_3_2_78_2","first-page":"349","article-title":"Possible biological indicators of the response to recombinant tumour necrosis factor alpha in patients with advanced neoplasms","volume":"17","author":"Braczkowski R.","year":"1998","unstructured":"R. Braczkowski, B. Zubelewicz, W. Romanowski, P. Lissoni, F. Brivio, Possible biological indicators of the response to recombinant tumour necrosis factor alpha in patients with advanced neoplasms. J. Exp. Clin. Cancer Res. 17, 349\u2013354 (1998).","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-017-2266-5"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.02.002"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.4.1397"},{"key":"e_1_3_2_82_2","first-page":"e52553","article-title":"Busulfan as a myelosuppressive agent for generating stable high-level bone marrow chimerism in mice","volume":"98","author":"Peake K.","year":"2015","unstructured":"K. Peake, J. Manning, C. A. Lewis, C. Barr, F. Rossi, C. Krieger, Busulfan as a myelosuppressive agent for generating stable high-level bone marrow chimerism in mice. J. Vis. Exp. 98, e52553 (2015).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2020.100159"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01059-0"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0638-x"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.147"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1586"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adu3313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T18:58:22Z","timestamp":1764183502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adu3313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":86,"journal-issue":{"issue":"826","published-print":{"date-parts":[[2025,11,26]]}},"alternative-id":["10.1126\/scitranslmed.adu3313"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adu3313","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"2024-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadu3313"}}