{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:26:58Z","timestamp":1790148418087,"version":"4.0.1"},"reference-count":78,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"799","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2025,5,21]]},"abstract":"<jats:p>\n            Gonococcus, a bacterium resistant to most antibiotics, causes more than 80 million cases of gonorrhea annually and is considered a high-priority pathogen by the World Health Organization. Recently, vaccine development prospects were boosted by reports that licensed meningococcus serogroup B (MenB) vaccines provided partial protection against gonococcal infection. To determine antigens responsible for cross-protection, memory B cells isolated from 4CMenB-vaccinated volunteers were single cell\u2013sorted to identify antibodies that kill gonococcus in a bactericidal assay. Nine different antibodies, all deriving from the\n            <jats:italic toggle=\"yes\">IGHV4-34<\/jats:italic>\n            germline and carrying an unusually long heavy-chain complementarity-determining region 3, recognized the PorB protein; four others recognized the lipooligosaccharide; and another four had unknown specificity. One of the PorB-specific antibodies provided protection in a mouse model of gonococcus infection. The identification of PorB and lipooligosaccharide as key antigens of gonococcal and meningococcal immunity provides a mechanistic explanation of the cross-protection observed in the clinic and shows that isolating human monoclonal antibodies from vaccinees can be instrumental for bacterial antigen discovery.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.adv0969","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T18:00:24Z","timestamp":1747850424000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Human monoclonal antibodies targeting subdominant meningococcal antigens confer cross-protection against gonococcus"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-9886","authenticated-orcid":true,"given":"Marco","family":"Troisi","sequence":"first","affiliation":[{"name":"Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life 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