{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T13:14:03Z","timestamp":1793452443152,"version":"4.5.0"},"reference-count":68,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"822","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2025,10,29]]},"abstract":"<jats:p>\n                    Time-restricted eating (TRE) is a promising strategy to improve metabolic outcomes. However, it remains unclear whether TRE has cardiometabolic benefits in an isocaloric setting and whether its effects depend on the eating timing. We conducted a randomized crossover trial in 31 women with overweight or obesity to directly compare the effects of a 2-week early TRE (eTRE; eating from 8:00 to 16:00) and a 2-week late TRE (lTRE; eating from 13:00 to 21:00) on insulin sensitivity, cardiometabolic risk factors, and the internal circadian phase. During the restricted 8-hour eating period, participants were asked to consume their habitual food quality and quantity. Insulin sensitivity did not differ between (\u22120.07; 95% CI, \u22120.77 to 0.62;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.60) or within (eTRE: 0.31; 95% CI, \u22120.14 to 0.76;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.11; lTRE: 0.19; 95% CI, \u22120.22 to 0.60;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.25) interventions. Twenty-four\u2013hour glucose, lipid, inflammatory, and oxidative stress markers showed no clinically meaningful between- or within-intervention differences. Participants demonstrated high timely adherence (eTRE, 96.5%; lTRE, 97.7%), unchanged dietary composition and physical activity, minor daily calorie deficit (eTRE, \u2212167\u00a0kilocalories\/day), and weight loss (eTRE, \u22121.08\u00a0kilograms; lTRE, \u22120.44\u00a0kilograms). In lTRE, the circadian phase in blood monocytes (24 minutes; 95% CI, \u22125 to 54 minutes;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.10) and sleep midpoint (15 minutes; 95% CI, 7 to 23 minutes;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) occurred later compared with eTRE. Overall, in an intended isocaloric setting, neither eTRE nor lTRE improves insulin sensitivity or other cardiometabolic traits, despite a shift of internal circadian clocks.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adv6787","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:58:20Z","timestamp":1761760700000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":22,"title":["Intended isocaloric time-restricted eating shifts circadian clocks but does not improve cardiometabolic health in women with overweight"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7827-625X","authenticated-orcid":true,"given":"Beeke","family":"Peters","sequence":"first","affiliation":[{"name":"Department of Molecular Metabolism and Precision Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany."},{"name":"Research Group 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