{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:53:08Z","timestamp":1793170388623,"version":"4.5.0"},"reference-count":93,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"838","funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY024932"],"award-info":[{"award-number":["EY024932"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY032518"],"award-info":[{"award-number":["EY032518"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY034353"],"award-info":[{"award-number":["EY034353"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY023295"],"award-info":[{"award-number":["EY023295"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY036943"],"award-info":[{"award-number":["EY036943"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,2,25]]},"abstract":"<jats:p>\n                    Adult mammalian central nervous system (CNS) axons do not spontaneously regenerate after injury. We recently identified multiple genes that promote optic nerve regeneration, protect retinal ganglion cell (RGC) somata and axons, and preserve visual function in mouse glaucoma models. Here, we investigated the downstream molecular mechanisms driving the regenerative and neuroprotective effects of the actin depolymerization molecule gelsolin (\n                    <jats:italic toggle=\"yes\">Gsn<\/jats:italic>\n                    , one of the top up-regulated genes in regenerating RGCs) and the actin regulatory molecules (annexin A2, destrin, cofilin, profilin, latrunculin, and cytochalasin). Adeno-associated virus (AAV)\u2013mediated specific expression of these genes in RGCs or topical delivery of small molecules promoted optic nerve regeneration and RGC protection in an optic nerve crush model and an ocular hypertension glaucoma mouse model. These regenerative effects were associated with a decrease in F-actin in axon shafts. Ex vivo mechanistic studies, furthermore, demonstrated that actin depolymerization enhances axonal mitochondrial transport in RGC axons, suggesting a mechanistic nodal point on which these pro-regeneration molecules converge. We showed that the natural compound latrunculin B targets this unified mechanism in both mouse and human RGCs to promote axon outgrowth. In addition, we detected up-regulated F-actin in aqueous humors of patients with severe glaucoma, emphasizing the translational potential of our findings.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adw0908","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T18:58:16Z","timestamp":1772045896000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Actin depolymerization promotes axon regeneration by restoring axonal mitochondrial transport in mouse models of optic neuropathy"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-5995","authenticated-orcid":true,"given":"Liang","family":"Li","sequence":"first","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Feng","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4013-8322","authenticated-orcid":true,"given":"Jinyu","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5976-949X","authenticated-orcid":true,"given":"Jenny","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2075-0626","authenticated-orcid":true,"given":"Michaela","family":"Dujava \u017dd\u00edmalov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Faculty of Science, Charles University, Prague 12800, Czechia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Biology, Stanford University, Palo Alto, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2843-7453","authenticated-orcid":true,"given":"Ziming","family":"Luo","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-3956","authenticated-orcid":true,"given":"Haoliang","family":"Huang","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8941-0812","authenticated-orcid":true,"given":"Dong","family":"Liu","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3188-6559","authenticated-orcid":true,"given":"Fengwen","family":"Huang","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-2948","authenticated-orcid":true,"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0593-4542","authenticated-orcid":true,"given":"Yuyang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyun","family":"Bian","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshen","family":"Ma","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6557-5337","authenticated-orcid":true,"given":"In-Jee","family":"You","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Yan","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Li","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0360-4419","authenticated-orcid":true,"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghong","family":"Xie","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Krish","sequence":"additional","affiliation":[{"name":"Saratoga High School, Saratoga, CA 95070, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5260-8972","authenticated-orcid":true,"given":"Xin","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-7360","authenticated-orcid":true,"given":"Jeffrey Louis","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-9093","authenticated-orcid":true,"given":"Xiaoke","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biology, Stanford University, Palo Alto, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2026-2238","authenticated-orcid":true,"given":"Marcus","family":"Braun","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Prague West 25250, Czechia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8474-053X","authenticated-orcid":true,"given":"Zdenek","family":"Lansky","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Prague West 25250, Czechia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8628-0282","authenticated-orcid":true,"given":"Ruobo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-1649","authenticated-orcid":true,"given":"Yang","family":"Hu","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161566"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00558"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6416"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1289-z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.14908"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.06.022"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201412030"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316857"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.638558"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25214954"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218342"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018226"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/325362a0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.7.3841"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2157283"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005552"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.07.001"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.07.007"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0648-19.2019"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02459.2000"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125771"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.08.014"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107537"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.11.011"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1621-10.2010"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0317-2"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.035"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr381"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.18.8195-8209.2004"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006869107"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt528"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.11.025"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.10.060"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201605101"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201702187"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57135-8"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2018.7"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00715.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101021"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0102-20.2020"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-376-3_4"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.05.015"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08231"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2972"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601078"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232251"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201902001"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21580"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.09.055"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68148"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10594"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33799-4"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2024.09.005"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.02.017"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.09.019"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100953"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30489-7"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113038"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.45881"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88690-x"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.021"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.3.5.1"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.17-0059"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2890"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-022-01225-4"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2024.109887"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2011.10.024"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092516"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.06.018"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.04.014"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.08.006"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e16-04-0253"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12886"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0313-6"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34006-5"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.03.015"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111324"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680600672185"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.095"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.026"},{"key":"e_1_3_2_84_2","first-page":"S110","article-title":"[Advances in brain protection]","volume":"43","author":"Sakabe T.","year":"1994","unstructured":"T. Sakabe, K. Nakakimura, [Advances in brain protection]. Masui 43 ( suppl.), S110\u2013S119 (1994).","journal-title":"Masui"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705043114"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153529"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04581"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.010"},{"key":"e_1_3_2_89_2","article-title":"A reversible silicon oil-induced ocular hypertension model in mice","volume":"153","author":"Zhang J.","year":"2019","unstructured":"J. Zhang, F. Fang, L. Li, H. Huang, H. C. Webber, Y. Sun, V. B. Mahajan, Y. Hu, A reversible silicon oil-induced ocular hypertension model in mice. J. Vis. Exp. 153, e60409 (2019).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00109"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpcb.107"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-12-04615.2000"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-252-6_2"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01507-1"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adw0908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:01:01Z","timestamp":1776700861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adw0908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":93,"journal-issue":{"issue":"838","published-print":{"date-parts":[[2026,2,25]]}},"alternative-id":["10.1126\/scitranslmed.adw0908"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adw0908","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"2025-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadw0908"}}