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Transl. Med."],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:p>\n                    Diabetic peripheral neuropathy (DPN) is a debilitating medical condition that affects millions of individuals, causing neuropathic pain and chronic wounds. Despite its substantial impact, there are currently no effective disease-modifying treatments available to prevent or reverse the progression of nerve damage. By regulating neuroinflammation, matrix metalloproteinase-9 (MMP-9) is both sufficient and required for the pathogenesis of neuropathy, representing a promising drug target for DPN; however, small-molecule inhibitors often lack target specificity. We developed a panel of selective, potent, and proteolytically stable monoclonal antibodies (mAbs) that inhibit MMP-9 activity as a treatment for DPN. We found that systematic administration of MMP-9 inhibitory mAbs alleviated mechanical and cold pain symptoms in diabetic mouse models and restored hind paw wound healing in diabetic mice. MMP-9 mAbs also reduced epidermal nerve fiber degeneration in diabetic mice by enhancing nerve mitochondrial function and promoting skin angiogenesis. Furthermore, we determined that MMP-9 expression in human dorsal root ganglia is increased among patients with diabetes, and human genetic analysis revealed that both rare coding of\n                    <jats:italic toggle=\"yes\">MMP9<\/jats:italic>\n                    and its common variants are associated with neuropathic pain phenotypes. Together, these translational findings indicate that MMP-9\u2013specific mAbs hold potential as disease-modifying therapies for peripheral neuropathy and for reducing lower extremity complications associated with diabetes.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adw3558","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:58:12Z","timestamp":1788976692000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Monoclonal antibodies inhibiting MMP-9 activity alleviate peripheral neuropathy in diabetic mice"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5506-9648","authenticated-orcid":true,"given":"Ki Baek","family":"Lee","sequence":"first","affiliation":[{"name":"Institute of Molecular Medicine, Texas Therapeutics Institute, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, 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