{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:19:57Z","timestamp":1793067597549,"version":"4.5.0"},"reference-count":77,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"827","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG066519"],"award-info":[{"award-number":["AG066519"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG069701"],"award-info":[{"award-number":["AG069701"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG073787"],"award-info":[{"award-number":["AG073787"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG061895"],"award-info":[{"award-number":["AG061895"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AG073088"],"award-info":[{"award-number":["T32 AG073088"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AG000096"],"award-info":[{"award-number":["T32 AG000096"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AG073088"],"award-info":[{"award-number":["T32 AG073088"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE-AC02-76SF00515"],"award-info":[{"award-number":["DE-AC02-76SF00515"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["P30-GM133894"],"award-info":[{"award-number":["P30-GM133894"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U2C-DK119886"],"award-info":[{"award-number":["U2C-DK119886"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Aging","award":["P30-AG10161"],"award-info":[{"award-number":["P30-AG10161"]}]},{"name":"National Institute of Aging","award":["R01-AG15819"],"award-info":[{"award-number":["R01-AG15819"]}]},{"name":"National Institute of Aging","award":["R01-AG17917"],"award-info":[{"award-number":["R01-AG17917"]}]},{"name":"National Institute of Aging","award":["U01-AG32984"],"award-info":[{"award-number":["U01-AG32984"]}]},{"name":"National Institute of Aging","award":["U01-AG46152"],"award-info":[{"award-number":["U01-AG46152"]}]},{"name":"National Institute of Aging","award":["U01-AG046170"],"award-info":[{"award-number":["U01-AG046170"]}]},{"name":"National Institute of Aging","award":["U01-AG046139"],"award-info":[{"award-number":["U01-AG046139"]}]},{"name":"National Institute of Aging","award":["U24-AG061340"],"award-info":[{"award-number":["U24-AG061340"]}]},{"name":"National Institute of Aging","award":["U01-AG61356"],"award-info":[{"award-number":["U01-AG61356"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2025,12,3]]},"abstract":"<jats:p>\n                    The Alzheimer\u2019s disease (AD) genetic landscape identified microglia as a key disease-modifying cell type. Paired immunoglobulin-like type 2 receptor alpha (PILRA) is an immunoreceptor tyrosine\u2013based inhibitory motif domain\u2013containing inhibitory receptor, expressed by myeloid cells such as microglia. The known protective\n                    <jats:italic toggle=\"yes\">PILRA<\/jats:italic>\n                    G78R gene variant reduces AD risk in\n                    <jats:italic toggle=\"yes\">apolipoprotein E4<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                    ) carriers and is enriched in a cohort of healthy centenarians. However, mechanisms underlying protective effects in microglia are undefined. Here, we identified biological functions of PILRA in human induced pluripotent stem cell\u2013derived microglia (iMG) and chimeric AD mice.\n                    <jats:italic toggle=\"yes\">PILRA<\/jats:italic>\n                    knockout (KO) in iMG rescued ApoE4-mediated immunometabolic deficits and prevented lipotoxicity through increased lipid storage, improved mitochondrial bioenergetics, and antioxidant activity.\n                    <jats:italic toggle=\"yes\">PILRA<\/jats:italic>\n                    KO also enhanced microglial chemotaxis and attenuated inflammation. With pharmacological inhibitor studies, we showed that peroxisome proliferator\u2013activated receptor and signal transducer and activator of transcription 1\/3 mediated\n                    <jats:italic toggle=\"yes\">PILRA<\/jats:italic>\n                    -dependent microglial functions. AD mice transplanted with human\n                    <jats:italic toggle=\"yes\">PILRA<\/jats:italic>\n                    KO microglia exhibited reduced amyloid pathology and rescued synaptic markers. A high-affinity ligand blocking PILRA antibody phenocopied\n                    <jats:italic toggle=\"yes\">PILRA<\/jats:italic>\n                    KO iMG. These findings suggest that PILRA is a pharmacologically tractable therapeutic target for AD.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adw7428","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T18:58:11Z","timestamp":1764788291000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":10,"title":["Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer\u2019s disease"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6376-1649","authenticated-orcid":true,"given":"Tanya N.","family":"Weerakkody","sequence":"first","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-7234","authenticated-orcid":true,"given":"Hanna","family":"Sabelstr\u00f6m","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan V.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-6592","authenticated-orcid":true,"given":"Jean Paul","family":"Chadarevian","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697 USA."},{"name":"Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA."},{"name":"Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7037-1603","authenticated-orcid":true,"given":"Marcus Y.","family":"Chin","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tatarakis","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas E.","family":"Propson","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-3915","authenticated-orcid":true,"given":"Do Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9122-1451","authenticated-orcid":true,"given":"Richard","family":"Theolis","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7110-403X","authenticated-orcid":true,"given":"Gian Carlo G.","family":"Parico","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1730-783X","authenticated-orcid":true,"given":"Hiwot","family":"Misker","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-7076","authenticated-orcid":true,"given":"Jennifer E.","family":"Kung","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5906-0843","authenticated-orcid":true,"given":"Abira","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaneth","family":"Robles Colmenares","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0917-5717","authenticated-orcid":true,"given":"Taggra-Nicole","family":"Jackson","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-5619","authenticated-orcid":true,"given":"Ahlam N.","family":"Qerqez","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srijana","family":"Balasundar","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7189-1427","authenticated-orcid":true,"given":"Sonnet S.","family":"Davis","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1257-2025","authenticated-orcid":true,"given":"Connie","family":"Ha","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5780-8241","authenticated-orcid":true,"given":"Rajarshi","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7947-2585","authenticated-orcid":true,"given":"Ritesh","family":"Ravi","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Rana","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6250-320X","authenticated-orcid":true,"given":"Kyla","family":"Germain","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Tao","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-7512","authenticated-orcid":true,"given":"Ken","family":"Xiong","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1372-4736","authenticated-orcid":true,"given":"Dylan","family":"Braun","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Raju","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-2043","authenticated-orcid":true,"given":"Kang-Chieh","family":"Huang","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7772-9340","authenticated-orcid":true,"given":"Lihong","family":"Zhan","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-3746","authenticated-orcid":true,"given":"Jing L.","family":"Guo","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Safari Yazd","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6168-2119","authenticated-orcid":true,"given":"Lily","family":"Sarrafha","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-5904","authenticated-orcid":true,"given":"Joia Kai","family":"Capocchi","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-9850","authenticated-orcid":true,"given":"Jonathan","family":"Hasselmann","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA."},{"name":"Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina L.","family":"Chadarevian","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697 USA."},{"name":"Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8353-4244","authenticated-orcid":true,"given":"Christina","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA."},{"name":"Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9840-078X","authenticated-orcid":true,"given":"Kimiya","family":"Mansour","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0447-7722","authenticated-orcid":true,"given":"Ghazaleh","family":"Eskandari-Sedighi","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA."},{"name":"Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1413-5091","authenticated-orcid":true,"given":"Niccol\u00f2","family":"Tesi","sequence":"additional","affiliation":[{"name":"Delft Bioinformatics Lab, Delft University of Technology, Mekelweg 2, 2628CD Delft, Netherlands."},{"name":"Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands."},{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1606-8643","authenticated-orcid":true,"given":"Sven","family":"van der Lee","sequence":"additional","affiliation":[{"name":"Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands."},{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hulsman","sequence":"additional","affiliation":[{"name":"Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgii","family":"Oshegov","sequence":"additional","affiliation":[{"name":"Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande","family":"Pijnenburg","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-959X","authenticated-orcid":true,"given":"Meredith","family":"Calvert","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7688-3087","authenticated-orcid":true,"given":"Henne","family":"Holstege","sequence":"additional","affiliation":[{"name":"Delft Bioinformatics Lab, Delft University of Technology, Mekelweg 2, 2628CD Delft, Netherlands."},{"name":"Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands."},{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8119-326X","authenticated-orcid":true,"given":"Jung H.","family":"Suh","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-1265","authenticated-orcid":true,"given":"Gilbert","family":"Di Paolo","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8554-6456","authenticated-orcid":true,"given":"Hayk","family":"Davtyan","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA."},{"name":"Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3012-7881","authenticated-orcid":true,"given":"Joseph W.","family":"Lewcock","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7770-7157","authenticated-orcid":true,"given":"Mathew","family":"Blurton-Jones","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697 USA."},{"name":"Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA."},{"name":"Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6901-1176","authenticated-orcid":true,"given":"Kathryn M.","family":"Monroe","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc., South San Francisco, CA 94080 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01024-z"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211851"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv402"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2308-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007427"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17058-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01263-4"},{"key":"e_1_3_2_10_2","first-page":"793","article-title":"Ramp sequence may explain synonymous variant association with Alzheimer\u2019s disease in the paired immunoglobulin-like type 2 receptor alpha (PILRA)","volume":"13","author":"Miller J. B.","year":"2025","unstructured":"J. B. Miller, J. A. Brandon, L. M. Harmon, H. W. Sabra, C. C. Lucido, J. D. G. Murcia, K. A. Nations, S. H. Payne, M. T. W. Ebbert, J. S. K. Kauwe, P. G. Ridge, Ramp sequence may explain synonymous variant association with Alzheimer\u2019s disease in the paired immunoglobulin-like type 2 receptor alpha (PILRA). Biomedicine 13, 793 (2025).","journal-title":"Biomedicine"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.03.004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112196"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07185-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00284.2005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0451-3"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.02.014"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0291-z"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.036"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0650-6"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.06.005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01239"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200301097"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42096-7"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.13.3660"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2014.51"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413187200"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.15153"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164551"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.10.027"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.07.002"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220857"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19227-5"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006599"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324105111"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.07.005"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.10.023"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.05.008"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01869-3"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.12.007"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0566-1"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90006-X"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108482200"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00269-1"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12081116"},{"key":"e_1_3_2_46_2","first-page":"950","article-title":"Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: A preliminary study","volume":"13","author":"Watson G. S.","year":"2005","unstructured":"G. S. Watson, B. A. Cholerton, M. A. Reger, L. D. Baker, S. R. Plymate, S. Asthana, M. A. Fishel, J. J. Kulstad, P. S. Green, D. G. Cook, S. E. Kahn, M. L. Keeling, S. Craft, Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: A preliminary study. Am. J. Geriatr. Psychiatry 13, 950\u2013958 (2005).","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500369"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-092823-113814"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01881-6"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.274142"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091309"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8373"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40681-4"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay1359"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01208-7"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170850"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63639-3.00001-3"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000411"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201911227"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4235"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa1081"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.116"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00796-z"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0297-x"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.002"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-182"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_2_70_2","first-page":"416","article-title":"A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer\u2019s disease models","volume":"26","author":"van Lengerich B.","year":"2023","unstructured":"B. van Lengerich, L. Zhan, D. Xia, D. Chan, D. Joy, J. I. Park, D. Tatarakis, M. Calvert, S. Hummel, S. Lianoglou, M. E. Pizzo, R. Prorok, E. Thomsen, L. M. Bartos, P. Beumers, A. Capell, S. S. Davis, L. de Weerd, J. C. Dugas, J. Duque, T. Earr, K. Gadkar, T. Giese, A. Gill, J. Gn\u00f6rich, C. Ha, M. Kannuswamy, D. J. Kim, S. T. Kunte, L. H. Kunze, D. Lac, K. Lechtenberg, A. W. Leung, C. C. Liang, I. Lopez, P. McQuade, A. Modi, V. O. Torres, H. N. Nguyen, I. Pes\u00e4maa, N. Propson, M. Reich, Y. Robles-Colmenares, K. Schlepckow, L. Slemann, H. Solanoy, J. H. Suh, R. G. Thorne, C. Vieira, K. Wind-Mark, K. Xiong, Y. J. Y. Zuchero, D. Diaz, M. S. Dennis, F. Huang, K. Scearce-Levie, R. J. Watts, C. Haass, J. W. Lewcock, G. Di Paolo, M. Brendel, P. E. Sanchez, K. M. Monroe, A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer\u2019s disease models. Nat. Neurosci. 26, 416\u2013429 (2023).","journal-title":"Nat. Neurosci."},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.slasd.2025.100208"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12577"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01767-y"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw777"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798317017235"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320716111"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adw7428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T18:58:17Z","timestamp":1764788297000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adw7428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":77,"journal-issue":{"issue":"827","published-print":{"date-parts":[[2025,12,3]]}},"alternative-id":["10.1126\/scitranslmed.adw7428"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adw7428","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]},"assertion":[{"value":"2025-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadw7428"}}