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Transl. Med."],"published-print":{"date-parts":[[2026,1,28]]},"abstract":"<jats:p>\n                    Invasive candidiasis is a leading cause of nosocomial bloodstream infection associated with high mortality, and there is a pressing need to develop biomarker-guided antifungal therapy to improve clinical outcomes. Meteorin-like (METRNL) is a cytokine that can act as a high-affinity ligand for the stem cell factor receptor KIT; however, the functional role of METRNL in fungal infection remains unclear. Here, we found that METRNL acts as a disease-promoting immune checkpoint to facilitate invasive\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    ) infection. Mice deficient in METRNL were refractory to a lethal systemic infection with\n                    <jats:italic toggle=\"yes\">C. albicans.<\/jats:italic>\n                    Treatment with a METRNL blocking antibody protected mice from invasive\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    infection, whereas treatment with recombinant METRNL or overexpression of endogenous METRNL dampened fungal clearance and aggravated disease mortality but not in mice with macrophage-specific deletion of KIT. The METRNL-KIT axis decreased dectin-1 expression and impaired fungal phagocytosis and killing capacity in macrophages, which was dependent on signal transducer and activator of transcription 3 signaling, thereby negatively regulating host antifungal immunity. In two independent cohorts, patients with candidemia had elevated circulating METRNL concentrations compared with patients with bacteremia or healthy volunteers. In both cohorts, a higher circulating METRNL concentration was associated with poor survival. Therefore, our study provides mechanistic and translational insights into how METRNL orchestrates macrophage-dependent antifungal immunity, implying that a potential theranostic approach involving blood-circulating METRNL-guided patient stratification and targeted therapy of blocking METRNL may help improve the management of human fungal disease through a precision medicine strategy.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adw8481","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T18:58:25Z","timestamp":1769626705000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Meteorin-like is associated with poor outcome in invasive candidiasis in mouse models and in humans"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-4450","authenticated-orcid":true,"given":"Jiayu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China."},{"name":"Department of Laboratory Medicine, Seventh People\u2019s Hospital of Chongqing, Central Hospital Affiliated to Chongqing University of Technology, Chongqing 400054, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-2489","authenticated-orcid":true,"given":"Hao","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, 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