{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:32:17Z","timestamp":1793367137148,"version":"4.5.0"},"reference-count":79,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"839","license":[{"start":{"date-parts":[[2027,3,4]],"date-time":"2027-03-04T00:00:00Z","timestamp":1804118400000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.science.org\/content\/page\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-2034835"],"award-info":[{"award-number":["DGE-2034835"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2T32CA009120-46A1, 5T32CA009120-45, 5T32CA009120-44"],"award-info":[{"award-number":["2T32CA009120-46A1, 5T32CA009120-45, 5T32CA009120-44"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIGMS T32 GM008042; NIGMS T32 GM152342"],"award-info":[{"award-number":["NIGMS T32 GM008042; NIGMS T32 GM152342"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","award":["Lloyd J. Old STAR Award"],"award-info":[{"award-number":["Lloyd J. Old STAR Award"]}],"id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California Los Angeles","doi-asserted-by":"crossref","award":["Whitcome Fellowship"],"award-info":[{"award-number":["Whitcome Fellowship"]}],"id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jean and Stephen Kaplan","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100000738","name":"Department of Veteran Affairs","doi-asserted-by":"crossref","award":["I01BX006019"],"award-info":[{"award-number":["I01BX006019"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000738","name":"Department of Veteran Affairs","doi-asserted-by":"crossref","award":["I01BX006411"],"award-info":[{"award-number":["I01BX006411"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,3,4]]},"abstract":"<jats:p>Chimeric antigen receptor (CAR) T cell therapy has shown limited efficacy against solid tumors, which often reside in highly immunosuppressive tumor microenvironments (TMEs). TMEs can be highly abundant in vascular endothelial growth factor A (VEGF), which contributes to immunosuppression and abnormal tumor vasculature. Here, we found that CAR T cells engineered to secrete an anti-VEGF single-chain variable fragment (CAR-\u03b1VEGF T cells) achieved superior antitumor efficacy against multiple in vivo models of ovarian cancer and glioma, outperforming conventional CAR T cells with and without combination anti-VEGF antibody therapy. Microscopy, flow cytometry, and transcriptomic analyses revealed that armoring the CAR T cells with anti-VEGF single-chain variable fragments enhanced their activation and mitochondrial fitness and enriched immune-stimulatory signatures among endogenous immune cells in the tumor-bearing brain. Moreover, CAR-\u03b1VEGF T cells circumvented multiple detrimental effects associated with on-target CAR T cell therapy, including infiltration of suppressive myeloid cells, exaggerated vasculature abnormalities, and hypoxia. Together, our results provide rationale for the clinical translation of CAR-\u03b1VEGF T cells as a safe and potent therapy for solid tumors characterized by elevated VEGF.<\/jats:p>","DOI":"10.1126\/scitranslmed.adw9286","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:58:28Z","timestamp":1772650708000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Engineering CAR T cells to secrete VEGF-neutralizing scFvs enhances antitumor activity against solid tumors"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4333-5305","authenticated-orcid":true,"given":"Torahito A.","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-867X","authenticated-orcid":true,"given":"Ryan M.","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9819-6619","authenticated-orcid":true,"given":"Justin D.","family":"Clubb","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5811-3444","authenticated-orcid":true,"given":"Shao-Hsi","family":"Hung","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 115201, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4372-6149","authenticated-orcid":true,"given":"Laura B.","family":"James-Allan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8022-7288","authenticated-orcid":true,"given":"Gabriella","family":"DiBernardo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Shafer","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0385-3276","authenticated-orcid":true,"given":"Amber","family":"Bouren","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2906-5786","authenticated-orcid":true,"given":"Melanie","family":"Ayala Ceja","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2208-8882","authenticated-orcid":true,"given":"Sophie","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8214-7190","authenticated-orcid":true,"given":"Andr\u00e9a B.","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-9651","authenticated-orcid":true,"given":"Ajit S.","family":"Divakaruni","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Memarzadeh","sequence":"additional","affiliation":[{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"VA Greater Los Angeles Healthcare System, Los Angeles, CA 90095, USA."},{"name":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5185-1169","authenticated-orcid":true,"given":"Han-Chung","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 115201, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5583-119X","authenticated-orcid":true,"given":"Yvonne Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Parker Institute for Cancer Immunotherapy Center at UCLA, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.19462"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00189-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107952"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.04.004"},{"key":"e_1_3_2_6_2","first-page":"177","article-title":"Secretion of vascular endothelial growth factor in ovarian cancer","volume":"20","author":"Santin A. D.","year":"1999","unstructured":"A. D. Santin, P. L. Hermonat, A. Ravaggi, M. J. Cannon, S. Pecorelli, G. P. Parham, Secretion of vascular endothelial growth factor in ovarian cancer. Eur. J. Gynaecol. Oncol. 20, 177\u2013181 (1999).","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990219)84:1<10::AID-IJC3>3.0.CO;2-L"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.10.006"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01332-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26094"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140559"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1096-1096"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191040"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2014.998519"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102017"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915745"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2010"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-0964"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2408771"},{"key":"e_1_3_2_20_2","first-page":"vdac185","article-title":"Tandem chimeric antigen receptor (CAR) T cells targeting EGFRvIII and IL-13R\u03b12 are effective against heterogeneous glioblastoma","volume":"5","author":"Schmidts A.","year":"2023","unstructured":"A. Schmidts, A. A. Srivastava, R. Ramapriyan, S. R. Bailey, A. A. Bouffard, D. P. Cahill, B. S. Carter, W. T. Curry, G. P. Dunn, M. J. Frigault, E. R. Gerstner, J. Y. Ghannam, M. C. Kann, R. C. Larson, M. B. Leick, B. V. Nahed, L. G. Richardson, I. Scarf\u00f2, J. Sun, H. Wakimoto, M. V. Maus, B. D. Choi, Tandem chimeric antigen receptor (CAR) T cells targeting EGFRvIII and IL-13R\u03b12 are effective against heterogeneous glioblastoma. Neurooncol. Adv. 5, vdac185 (2023).","journal-title":"Neurooncol. Adv."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0407"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072113"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0192-1"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(03)00177-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1228"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00789"},{"key":"e_1_3_2_27_2","unstructured":"A. Kahnert D. Light D. Schneider R. Parry N. Satozawa T. Heitner S. Steidl U. Schubert Anti-mesothelin antibodies and uses thereof US Patent 9 023 351 (2015)."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.19.7282-7291.2000"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64505-1"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-19-0258"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03987"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0442"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00447-z"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30362-0"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02893-z"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02875-1"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2314390"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01544-7"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-0428"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610497"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noae126"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1501137"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-002181"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.134"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0310-8"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21865"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040806"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.1254"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2416"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900080"},{"key":"e_1_3_2_51_2","first-page":"100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu T.","year":"2021","unstructured":"T. Wu, E. Hu, S. Xu, M. Chen, P. Guo, Z. Dai, T. Feng, L. Zhou, W. Tang, L. Zhan, X. Fu, S. Liu, X. Bo, G. Yu, clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innovation 2, 100141 (2021).","journal-title":"Innovation"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.1.71"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01809"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12428"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4185"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119798"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4463"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade2292"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1996.tb00920.x"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-005583"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1378843"},{"key":"e_1_3_2_63_2","first-page":"5565","article-title":"Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions","volume":"60","author":"Lee C. G.","year":"2000","unstructured":"C. G. Lee, M. Heijn, E. Di Tomaso, G. Griffon-Etienne, M. Ancukiewicz, C. Koike, K. R. Park, N. Ferrara, R. K. Jain, H. D. Suit, Y. Boucher, Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 60, 5565\u20135570 (2000).","journal-title":"Cancer Res."},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14765"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.671.65.3"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114700"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-0040"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00281-9"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216480"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006708607666"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02612-0"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800033"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.12.061"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14208"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr260"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00619-4"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801415-8.00016-3"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9236-2_14"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.09.024"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adw9286","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adw9286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T17:59:10Z","timestamp":1773943150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adw9286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":79,"journal-issue":{"issue":"839","published-print":{"date-parts":[[2026,3,4]]}},"alternative-id":["10.1126\/scitranslmed.adw9286"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adw9286","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,4]]},"assertion":[{"value":"2025-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadw9286"}}