{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:13:18Z","timestamp":1789503198003,"version":"build-2803163510"},"reference-count":96,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"850","funder":[{"DOI":"10.13039\/100012479","name":"Weston Brain Institute","doi-asserted-by":"publisher","award":["TR201348"],"award-info":[{"award-number":["TR201348"]}],"id":[{"id":"10.13039\/100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN 154292"],"award-info":[{"award-number":["FDN 154292"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["ENG 173742"],"award-info":[{"award-number":["ENG 173742"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT 198046"],"award-info":[{"award-number":["PJT 198046"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alan and Susan Hudson Cornerstone Chair in Neurosurgery at University Health Network","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,5,20]]},"abstract":"<jats:p>Transcranial ultrasound stimulation (TUS) is a promising noninvasive technique for modulating deep brain targets and circuits with high spatial precision. For its successful clinical translation, confirmation of target engagement, together with a deeper understanding of the effects of TUS, is essential. To advance these goals, we obtained direct measures of neural activity using electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson\u2019s disease (PD) during TUS of deep and superficial targets, guided by magnetic resonance imaging\u2013based acoustic modeling and real-time neuronavigation. Seventeen patients were studied in the on-medication and off\u2013deep brain stimulation states. Each patient received one active and one sham session in a randomized order, and 13 of 17 patients (76%) completed a third session, which was always active. Each active condition targeted a single site\u2014either the primary motor cortex (M1), the globus pallidus internus (GPi), or the occipital cortex (control site)\u2014with 10 patients per active target. TUS effects on the STN were found to be target specific. Stimulation of the M1 reduced STN beta oscillation activity compared with sham stimulation and was associated with improvements in motor signs. These effects were brain state specific, showing distinct modulation patterns at rest versus during movement. In contrast, TUS targeting the GPi increased beta activity relative to control conditions and did not improve motor signs. Our results provide mechanistic evidence that TUS can safely and selectively modulate pathological brain rhythms in the STN in PD, supporting its potential as a targeted, noninvasive therapeutic modality.<\/jats:p>","DOI":"10.1126\/scitranslmed.ady1883","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:02:30Z","timestamp":1779300150000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Transcranial ultrasound stimulation of motor networks in Parkinson\u2019s disease informed by local field potential dynamics"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8419-7426","authenticated-orcid":true,"given":"Can","family":"Sarica","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON M5T 2S8, Canada."},{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4073-1911","authenticated-orcid":true,"given":"Ghazaleh","family":"Darmani","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON M5T 2S8, Canada."},{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-4137","authenticated-orcid":true,"given":"Hamidreza","family":"Ramezanpour","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, ON M3J 1L3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9871-038X","authenticated-orcid":true,"given":"Marcus","family":"Callister","sequence":"additional","affiliation":[{"name":"Edmond J. Safra Program in Parkinson's Disease Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, and Division of Neurology, University of Toronto, Toronto, ON M5T 2S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Santyr","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON M5T 2S8, Canada."},{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3126-8002","authenticated-orcid":true,"given":"Talyta","family":"Grippe","sequence":"additional","affiliation":[{"name":"Edmond J. Safra Program in Parkinson's Disease Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, and Division of Neurology, University of Toronto, Toronto, ON M5T 2S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Annirood","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasem","family":"Raies","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2697-4885","authenticated-orcid":true,"given":"Jean-Francois","family":"Nankoo","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nardin","family":"Samuel","sequence":"additional","affiliation":[{"name":"Edmond J. Safra Program in Parkinson's Disease Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, and Division of Neurology, University of Toronto, Toronto, ON M5T 2S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy Yi Rong","family":"Ding","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Vetkas","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institutet, 171 76 Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Fomenko","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON M5T 2S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Schall","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, ON M3J 1L3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Hodaie","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON M5T 2S8, Canada."},{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."},{"name":"Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON M5T 2S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneil K.","family":"Kalia","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON M5T 2S8, Canada."},{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."},{"name":"Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON M5T 2S8, Canada."},{"name":"KITE, University Health Network, Toronto, ON M5T 2S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1142-2842","authenticated-orcid":true,"given":"Agessandro","family":"Abrahao","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada."},{"name":"Harquail Centre for Neuromodulation, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada."},{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-4067","authenticated-orcid":true,"given":"Renato P.","family":"Munhoz","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."},{"name":"Edmond J. Safra Program in Parkinson's Disease Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, and Division of Neurology, University of Toronto, Toronto, ON M5T 2S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5346-0180","authenticated-orcid":true,"given":"Alfonso","family":"Fasano","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."},{"name":"Edmond J. Safra Program in Parkinson's Disease Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, and Division of Neurology, University of Toronto, Toronto, ON M5T 2S8, Canada."},{"name":"Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON M5T 2S8, Canada."},{"name":"KITE, University Health Network, Toronto, ON M5T 2S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-8587","authenticated-orcid":true,"given":"Samuel","family":"Pichardo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2T8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8371-8629","authenticated-orcid":true,"given":"Robert","family":"Chen","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."},{"name":"Edmond J. Safra Program in Parkinson's Disease Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, and Division of Neurology, University of Toronto, Toronto, ON M5T 2S8, Canada."},{"name":"Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON M5T 2S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8257-3694","authenticated-orcid":true,"given":"Andres M.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON M5T 2S8, Canada."},{"name":"Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada."},{"name":"Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON M5T 2S8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2024.e00330"},{"key":"e_1_3_2_3_2","first-page":"100599","article-title":"Trends and disparities in deep brain stimulation utilization in the United States: A nationwide inpatient sample analysis from 1993 to 2017","volume":"26","author":"Sarica C.","year":"2023","unstructured":"C. Sarica, C. R. Conner, K. Yamamoto, A. Yang, J. Germann, M. M. Lannon, N. Samuel, M. Colditz, B. Santyr, C. T. Chow, C. Iorio-Morin, D. H. Aguirre-Padilla, S. T. Lang, A. Vetkas, C. Cheyuo, A. Loh, G. Darmani, O. Flouty, V. Milano, M. Paff, M. Hodaie, S. K. Kalia, R. P. Munhoz, A. Fasano, A. M. Lozano, Trends and disparities in deep brain stimulation utilization in the United States: A nationwide inpatient sample analysis from 1993 to 2017. Lancet Reg. Health Am. 26, 100599 (2023).","journal-title":"Lancet Reg. Health Am."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2022.05.002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015771108"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002884"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2021.12.010"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-024-00368-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28040-1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep24170"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2017.12.020"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2115821119"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006980118"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.10.037"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.08.021"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aaa15c"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.07.015"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2012.09.009"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2014.06.011"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2021.01.003"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224311"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22743-7"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2024.10.008"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.07.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2024.03.001"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2024.04.005"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.88762.3"},{"key":"e_1_3_2_28_2","first-page":"RP100827","article-title":"Neuromodulation with ultrasound: Hypotheses on the directionality of effects and a community resource","volume":"13","author":"Caffaratti H.","year":"2024","unstructured":"H. Caffaratti, B. Slater, N. Shaheen, A. Rhone, R. Calmus, M. Kritikos, S. Kumar, B. Dlouhy, H. Oya, T. Griffiths, A. D. Boes, N. Trapp, M. Kaiser, J. Sallet, M. I. Banks, M. A. Howard, M. Zanaty, C. I. Petkov, Neuromodulation with ultrasound: Hypotheses on the directionality of effects and a community resource. Elife 13, RP100827 (2024).","journal-title":"Elife"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.05.008"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27952"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1151351"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.656430"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2022.01.002"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2022.06.002"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.708481"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2021.12.012"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57883-7"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29622"},{"key":"e_1_3_2_39_2","unstructured":"J.-F. Aubry D. Attali M. Schafer E. Fouragnan C. F. Caskey R. Chen G. Darmani E. J. Bubrick J. Sallet C. R. Butler C. J. Stagg M. C. Klein-Fl\u00fcgge S.-S. Yoo C. Holland B. Treeby E. Martin L. Verhagen K. B. Pauly ITRUSST consensus on biophysical safety for transcranial ultrasound stimulation. arXiv:2311.05359 [physics.bio-ph] (2023)."},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105372"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26858"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.09.027"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114150"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/ncn3.152"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3620"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.JNS171513"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.97184.3"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0282-08.2008"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2015.08.009"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26206"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2438-23.2024"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2022.10.001"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29836"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk3198"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","unstructured":"P.-Y. Fong B. R. Kop C. Evans V. G. Wijaya Y. Lin D. Cappotto J. S. A. Lee A. Latorre J. Song B. Treeby E. Martin J. Rothwell L. Verhagen S. Bestmann Failed double-blind replication of offline 5Hz-rTUS-induced corticospinal excitability. bioRxiv 2024.11.25.625187 [Preprint] (2024). https:\/\/doi.org\/10.1101\/2024.11.25.625187.","DOI":"10.1101\/2024.11.25.625187"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurom.2025.01.004"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-81102-w"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40998-0"},{"key":"e_1_3_2_59_2","doi-asserted-by":"crossref","unstructured":"D. Keeser L. Roell V. Meedt M. Ha\u00dflberger M. Korman E. Schulz M. Lueckel B. Karsli G. Hasanaj T. Fae\u00dfler G. Vural K.-Y. Chang L. Bulubas F. Padberg F. Raabe P. Falkai T. O. Bergmann B.-S. Rauchmann Modulating brain perfusion functional connectivity and metabolite patterns through theta burst transcranial ultrasonic stimulation. bioRxiv 2025.06.25.661571 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.06.25.661571.","DOI":"10.1101\/2025.06.25.661571"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111197"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2024.07.020"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2023.07.056"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00693-3"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx010"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.10.006"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.70095"},{"key":"e_1_3_2_67_2","doi-asserted-by":"crossref","unstructured":"M. Mohammadjavadi R. T. Ash G. H. Glover K. B. Pauly Optimization of MR-ARFI for human transcranial focused ultrasound. bioRxiv 2024.11.13.623314 [Preprint] (2024). https:\/\/doi.org\/10.1101\/2024.11.13.623314.","DOI":"10.1101\/2024.11.13.623314"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63020-1"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2025.3554935"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48576-8"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2024.12.003"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58132-7"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2025.10.012"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2025.103014"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-024-01314-3"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2025.1478534"},{"key":"e_1_3_2_77_2","doi-asserted-by":"crossref","unstructured":"J. Jung C. Atkinson-Clement M. Kaiser M. A. Lambon Ralph Transcranial focused ultrasound stimulation of the anterior temporal lobe enhances semantic memory by modulating brain morphology neurochemistry and neural dynamics. bioRxiv 2025.03.10.642483 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.03.10.642483.","DOI":"10.1101\/2025.03.10.642483"},{"key":"e_1_3_2_78_2","doi-asserted-by":"crossref","unstructured":"S. Clarke S. Mugglestone M. Lojkiewiez J. Marquez N. Bault E. Fouragnan S. Hughes Multi-focal ultrasound neuromodulation to the dorsal anterior cingulate cortex disrupts behavioural and neural pain processing. bioRxiv 2025.09.04.674195 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.09.04.674195.","DOI":"10.1101\/2025.09.04.674195"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.12.041"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2024.02.005"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1011-23.2023"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31827b97d6"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1081815"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.60.1.78"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.08.003"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00301-2"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.025"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116189"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2024.04.013"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2023.3274046"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abo1800"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/156869"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx252"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.119862"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2021.108153"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00300"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-019-0254-8"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.ady1883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:02:39Z","timestamp":1779300159000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.ady1883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":96,"journal-issue":{"issue":"850","published-print":{"date-parts":[[2026,5,20]]}},"alternative-id":["10.1126\/scitranslmed.ady1883"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.ady1883","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"assertion":[{"value":"2025-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eady1883"}}