{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:13:52Z","timestamp":1793812432652,"version":"4.6.1"},"reference-count":81,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"857","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EN 924\/5-1"],"award-info":[{"award-number":["EN 924\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EN 924\/5-2"],"award-info":[{"award-number":["EN 924\/5-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["457352540"],"award-info":[{"award-number":["457352540"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["511083451"],"award-info":[{"award-number":["511083451"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Berlin Institute of Health and Charit\u00e9 Universit\u00e4tsmedizin"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,7,8]]},"abstract":"<jats:p>\n                    Proliferative lupus nephritis (LN) is triggered by deposition of autoantibodies in glomeruli and paralleled by a T cell\u2013rich kidney infiltrate. Although these T cells have been attributed to the propagation of tissue injury, it is unclear how they are activated and whether T cell autoreactivity drives local inflammation. Kidney-infiltrating T cells are also observed in urine, where they have high resemblance to interstitial T cells. Therefore, urinary T cells are a proxy for investigating tissue pathogenesis. Here, we analyzed urinary T cells to elucidate whether a kidney-specific T cell autoimmune reaction contributes to tubulointerstitial inflammation in LN. Using single-cell RNA sequencing, we compared transcriptomes and clonotypes of T cells from the blood and urine of patients with active LN and showed that urinary T cells were mostly activated CD8 effector memory cells recruited from a circulating\n                    <jats:italic toggle=\"yes\">CX3CR1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    subset. Several urinary CD8 T cell clones were expanded. However, upon in vitro testing of their T cell receptors, we did not observe autoreactivity against autologous tubular epithelial cells. Instead, ~20% of expanded clonotypes were Epstein-Barr virus\u2013specific or cytomegalovirus-specific, but respective viral antigens were undetectable in kidney biopsies or urine. Conversely, kidney-infiltrating T cells had access to interleukin-15 and interferon-\u03b2 (IFN-\u03b2), and stimulation with these cytokines was sufficient to trigger degranulation and production of tumor necrosis factor, IFN-\u03b3, and granzyme K. Together, these results show that CD8\n                    <jats:sup>+<\/jats:sup>\n                    CX3CR1\n                    <jats:sup>+<\/jats:sup>\n                    T cells are recruited into the kidney in LN, where they are activated by cytokines, enabling them to contribute to local inflammation.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adz2015","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:58:12Z","timestamp":1783533492000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Cytokine-mediated activation of kidney-infiltrating CD8\n                    <sup>+<\/sup>\n                    T cells enables their contribution to inflammation in human lupus nephritis"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6089-4769","authenticated-orcid":true,"given":"Christopher M.","family":"Skopnik","sequence":"first","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7723-9234","authenticated-orcid":true,"given":"Jan","family":"Klocke","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."},{"name":"Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charit\u00e9 Clinician Scientist Program, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7164-5760","authenticated-orcid":true,"given":"Paul","family":"Freund","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2754-1540","authenticated-orcid":true,"given":"Diana","family":"Metzke","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3553-6406","authenticated-orcid":true,"given":"Lennard","family":"Ostendorf","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."},{"name":"Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charit\u00e9 Junior Clinician Scientist Program, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-2520","authenticated-orcid":true,"given":"Mario","family":"Bunse","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), Department of Microenvironmental Regulation in Autoimmunity and Cancer, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3566-1858","authenticated-orcid":true,"given":"Luka","family":"Prskalo","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kotzbauer","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2526-1621","authenticated-orcid":true,"given":"Christian","family":"Hinze","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Hannover Medical School, Hannover Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-8916","authenticated-orcid":true,"given":"Emil","family":"Grothgar","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-2300","authenticated-orcid":true,"given":"Nina","family":"Goerlich","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9322-0268","authenticated-orcid":true,"given":"Leonie","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6803-4755","authenticated-orcid":true,"given":"Christoph","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Nephropathology, Institute of Pathology, Friedrich-Alexander Universit\u00e4t, Erlangen-Nuremberg, Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-4626","authenticated-orcid":true,"given":"Arndt","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander Universit\u00e4t, Erlangen-Nuremberg, Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9117-3307","authenticated-orcid":true,"given":"Udo","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0434-7832","authenticated-orcid":true,"given":"Robert","family":"Biesen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1193-0097","authenticated-orcid":true,"given":"Tobias","family":"Alexander","sequence":"additional","affiliation":[{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."},{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7725-9526","authenticated-orcid":true,"given":"Anja E.","family":"Hauser","sequence":"additional","affiliation":[{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."},{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-0000","authenticated-orcid":true,"given":"Andreas","family":"Radbruch","sequence":"additional","affiliation":[{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3823-0920","authenticated-orcid":true,"given":"Kai-Uwe","family":"Eckardt","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3584-5292","authenticated-orcid":true,"given":"Falk","family":"Hiepe","sequence":"additional","affiliation":[{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."},{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4597-2087","authenticated-orcid":true,"given":"Andrey","family":"Kruglov","sequence":"additional","affiliation":[{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8015-6907","authenticated-orcid":true,"given":"Mir-Farzin","family":"Mashreghi","sequence":"additional","affiliation":[{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."},{"name":"German Center for Child and Adolescent Health (DZKJ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7254-3931","authenticated-orcid":true,"given":"Philipp","family":"Enghard","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"German Rheumatology Research Center, a Leibniz Institute (DRFZ), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.10.017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.223"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.14"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.11.023"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22654"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI155350"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283535801"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ady0210"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.4.1317"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh688"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.33488"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.360"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10432"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v31.pm9506678"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.05.051"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.06.020"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.025"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100885"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1632807100"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24136"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4189"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.124636"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0600-y"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00256"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0398-x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.07.032"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200526122"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.624122"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abo0686"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24730-4"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2023325"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0045-3"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2004.10.001"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78223-3"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092675799"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103031"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40813"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00429-6"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041389"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80564-6"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2005477117"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac7071"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200309000-00002"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.623944"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00575-07"},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","unstructured":"C. Sinzger M. Digel G. Jahn \u201cCytomegalovirus cell tropism\u201d in Cytomegalovirus vol. 325 of Current Topics in Microbiology and Immunology T. E. Shenk M. F. Stinski Eds. (Springer Berlin Heidelberg 2008) pp. 63\u201383.","DOI":"10.1007\/978-3-540-77349-8_4"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/385640a0"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-021-03473-0"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080862"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646387"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.8.1413"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.5.734"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00604.x"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2011.23"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21007"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-379"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv369"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.2022"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050882"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.074"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abe6968"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.8.876"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.08.010"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-138529"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.5.2739"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e3181998e03"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103609"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1179"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V971194"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201620"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309106175"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01108-9"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.063123"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.1.494"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08713-9"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020101528"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.172681"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-008-0649-4"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.115"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.23526"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.22117"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adz2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:58:25Z","timestamp":1783533505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adz2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":81,"journal-issue":{"issue":"857","published-print":{"date-parts":[[2026,7,8]]}},"alternative-id":["10.1126\/scitranslmed.adz2015"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adz2015","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"2025-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadz2015"}}