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Exogenous IL-10 or lymph node sequestration of T cells reduced placental type 17 T helper cells (T\n                    <jats:sub>H<\/jats:sub>\n                    17 cells) and abrogated preterm birth. In a human pregnancy cohort, we correlated urinary cytokines with birth outcomes and urine culture status. These analyses yielded an exploratory, noninvasive culture-agnostic system for evaluating preterm birth risk, implicating T cell\u2013related cytokines including IL-10, IL-15, GM-CSF, and RANTES. These findings demonstrate that our murine model provides a platform to investigate immunological and microbial factors governing UTI-associated preterm birth and, coupled with patient samples, may be used to identify candidate biomarkers and mechanistic targets for future investigation.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aea1228","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:00:27Z","timestamp":1787767227000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Urogenital immune signatures are associated with birth outcomes after maternal urinary tract infection"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3439-6376","authenticated-orcid":true,"given":"Samantha","family":"Ottinger","sequence":"first","affiliation":[{"name":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, 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