{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:51:47Z","timestamp":1793235107301,"version":"4.5.0"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"826","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2002957"],"award-info":[{"award-number":["GNT2002957"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:p>\n                    Inhibiting the inflammatory response to malaria offers a promising strategy to improve clinical outcomes and overcome immunoregulatory barriers that hinder development of antiparasitic immunity. We conducted a double-blind, randomized, placebo-controlled trial assessing whether ruxolitinib, a Janus-activated kinase (JAK) 1\/2 inhibitor, can reduce inflammatory responses and enhance antiparasitic immunity in malaria-na\u00efve volunteers inoculated with blood-stage\n                    <jats:italic toggle=\"yes\">Plasmodium falciparum<\/jats:italic>\n                    . Twenty participants were inoculated and, on day 8, randomized to receive artemether-lumefantrine with either ruxolitinib or placebo. Ninety days later, participants underwent a second inoculation. Ruxolitinib was safe and well tolerated; moreover, it attenuated inflammatory responses to the initial infection, with reduced posttreatment increases in C-reactive protein and markers of disease severity, including angiopoietin-2 and intercellular adhesion molecule-1. Ruxolitinib also enhanced immune memory after the second infection, with elevated human leukocyte antigen\u2013DRA and 4-1BB, consistent with increased T cell activation. These data support the further evaluation of ruxolitinib as an adjunctive treatment to improve clinical outcomes and boost antiparasitic immunity in clinical malaria.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aea2531","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T18:58:16Z","timestamp":1764183496000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with\n                    <i>Plasmodium falciparum<\/i>"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6715-9044","authenticated-orcid":true,"given":"Rebecca","family":"Webster","sequence":"first","affiliation":[{"name":"QIMR Berghofer, Brisbane, QLD 4006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3169-9849","authenticated-orcid":true,"given":"Damian A.","family":"Oyong","sequence":"additional","affiliation":[{"name":"Burnet Institute, Melbourne, VIC 3004, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-947X","authenticated-orcid":true,"given":"Stacey","family":"Llewellyn","sequence":"additional","affiliation":[{"name":"QIMR Berghofer, Brisbane, QLD 4006, Australia."},{"name":"George Institute for Global Health, NSW 2031, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azrin N.","family":"Abd-Rahman","sequence":"additional","affiliation":[{"name":"QIMR Berghofer, Brisbane, QLD 4006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Potter","sequence":"additional","affiliation":[{"name":"QIMR Berghofer, Brisbane, QLD 4006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5780-059X","authenticated-orcid":true,"given":"Reena","family":"Mukhiya","sequence":"additional","affiliation":[{"name":"Burnet Institute, Melbourne, VIC 3004, Australia."},{"name":"Griffith University, Brisbane, QLD 4101, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nischal","family":"Sahai","sequence":"additional","affiliation":[{"name":"University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7786-623X","authenticated-orcid":true,"given":"Indika","family":"Leelasena","sequence":"additional","affiliation":[{"name":"University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7520-9810","authenticated-orcid":true,"given":"Eniko","family":"Ujvary","sequence":"additional","affiliation":[{"name":"University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1820-199X","authenticated-orcid":true,"given":"Sue","family":"Mathison","sequence":"additional","affiliation":[{"name":"University of Sunshine Coast Clinical Trials, Brisbane, QLD 4101, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean W.","family":"Andrew","sequence":"additional","affiliation":[{"name":"QIMR Berghofer, Brisbane, QLD 4006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-8570","authenticated-orcid":true,"given":"Luzia","family":"Bukali","sequence":"additional","affiliation":[{"name":"QIMR Berghofer, Brisbane, QLD 4006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5241-2339","authenticated-orcid":true,"given":"Fabian","family":"de Labastida Rivera","sequence":"additional","affiliation":[{"name":"QIMR Berghofer, Brisbane, QLD 4006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-1797","authenticated-orcid":true,"given":"Jessica","family":"Engel","sequence":"additional","affiliation":[{"name":"QIMR Berghofer, Brisbane, QLD 4006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-849X","authenticated-orcid":true,"given":"Megan S. 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