{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:10:45Z","timestamp":1788977445624,"version":"build-2803163510"},"reference-count":77,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"866","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HD103805-01"],"award-info":[{"award-number":["1R01HD103805-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","award":["DAF2025-367748"],"award-info":[{"award-number":["DAF2025-367748"]}],"id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"crossref","award":["RP-2016-07-011"],"award-info":[{"award-number":["RP-2016-07-011"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["492697668"],"award-info":[{"award-number":["492697668"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C864\/A14136"],"award-info":[{"award-number":["C864\/A14136"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N003284\/1"],"award-info":[{"award-number":["MR\/N003284\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00006\/1"],"award-info":[{"award-number":["MC_UU_00006\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["492697668"],"award-info":[{"award-number":["492697668"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["101231435"],"award-info":[{"award-number":["101231435"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:p>\n                    Despite the introduction of genome sequencing (GS) for rare disease diagnostics, a genetic cause is not identified in most patients. Here, we explored the potential of proteomics to improve the diagnostic yield in 424 patients with rare diseases from the 100,000 Genomes Project (100kGP) without a genetic diagnosis. Serum proteomic profiling was performed using the Olink Explore 1536 assay (\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    \u00a0=\u00a01463 proteins). For 13 patients without genetic diagnoses, detection of lower serum protein \u201coutliers\u201d (\n                    <jats:italic toggle=\"yes\">z<\/jats:italic>\n                    -score\u00a0&lt;\u00a0\u22122) led to confirmed genetic diagnoses by resolving variants of uncertain significance or prioritizing genes for targeted GS reanalysis. For 23 additional patients without genetic diagnoses (64% of findings), we identified candidate gene-disease links and variants through convergent evidence from lower protein outliers and variants ranked through the variant prioritization tool Exomiser. For example, we identified a candidate heterozygous missense variant [Genome Aggregation Database (gnomAD) minor allele frequency\u00a0=\u00a00.006%] in\n                    <jats:italic toggle=\"yes\">tyrosine kinase with immunoglobulin-like and epidermal growth factor homology domains 1<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">TIE1<\/jats:italic>\n                    ) that was only present in a patient with lower TIE1 serum abundance (\n                    <jats:italic toggle=\"yes\">z<\/jats:italic>\n                    -score\u00a0=\u00a0\u22125.12) and their father, both of whom were affected by the same monogenic cardiac disorder, but in no other individuals from the 100kGP. Missense (52.5%) and splice region (27.5%) variants accounted for most diagnostic or candidate variants prioritized. This proof-of-principle study demonstrated that serum proteomics can support rare disease diagnosis and identify disease-causing genes in patients undiagnosed after GS, although successful implementation will likely depend on tissue specificity of protein expression, detectability in blood, proteomic platform coverage, and sensitivity.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aeb1331","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:58:12Z","timestamp":1788976692000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Proteomics identify disease-associated variants in patients with rare diseases undiagnosed after genome sequencing"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-7505","authenticated-orcid":true,"given":"Julia","family":"Carrasco-Zanini","sequence":"first","affiliation":[{"name":"Precision Healthcare University Research Institute, Queen Mary University of London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4577-8620","authenticated-orcid":true,"given":"Jorge","family":"Andrade","sequence":"additional","affiliation":[{"name":"Angiogenesis &amp; Metabolism Laboratory, Berlin Institute of Health at Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany."},{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-9963","authenticated-orcid":true,"given":"Maik","family":"Pietzner","sequence":"additional","affiliation":[{"name":"Precision Healthcare University Research Institute, Queen Mary University of London, London, UK."},{"name":"Computational Medicine, Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6265-6521","authenticated-orcid":true,"given":"Athanasios","family":"Kousathanas","sequence":"additional","affiliation":[{"name":"Genomics England, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3265-1591","authenticated-orcid":true,"given":"Julius O. B.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Queen Mary University of London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0539-9343","authenticated-orcid":true,"given":"Jenny","family":"Lord","sequence":"additional","affiliation":[{"name":"Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-7056","authenticated-orcid":true,"given":"Narasimha","family":"Telugu","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-5992","authenticated-orcid":true,"given":"Sebastian","family":"Diecke","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-3861","authenticated-orcid":true,"given":"Michael","family":"M\u00fclleder","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"Core Facility, High-Throughput Mass Spectrometry, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-3378","authenticated-orcid":true,"given":"Dominik","family":"Bierbaum","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0008-936X","authenticated-orcid":true,"given":"Letizia","family":"Vestito","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Queen Mary University of London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0736-9199","authenticated-orcid":true,"given":"Peter N.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9535-7413","authenticated-orcid":true,"given":"Markus","family":"Ralser","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"Core Facility, High-Throughput Mass Spectrometry, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Baralle","sequence":"additional","affiliation":[{"name":"Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1422-2993","authenticated-orcid":true,"given":"Nicholas J.","family":"Wareham","sequence":"additional","affiliation":[{"name":"MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, CB2 0QQ Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-1596","authenticated-orcid":true,"given":"Greg","family":"Elgar","sequence":"additional","affiliation":[{"name":"Genomics England, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5689-0036","authenticated-orcid":true,"given":"Michael","family":"Potente","sequence":"additional","affiliation":[{"name":"Angiogenesis &amp; Metabolism Laboratory, Berlin Institute of Health at Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany."},{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0538-8211","authenticated-orcid":true,"given":"Matthew A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Genomics England, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9295-3594","authenticated-orcid":true,"given":"Mark","family":"Caulfield","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Queen Mary University of London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5836-9850","authenticated-orcid":true,"given":"Damian","family":"Smedley","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Queen Mary University of London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-7344","authenticated-orcid":true,"given":"Claudia","family":"Langenberg","sequence":"additional","affiliation":[{"name":"Precision Healthcare University Research Institute, Queen Mary University of London, London, UK."},{"name":"Computational Medicine, Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany."},{"name":"Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61124"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-018-0053-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035790"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0288875"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-033353"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12663"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal5209"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0457-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.01.012"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01019-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-025-00493-5"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"R. Kopajtich D. Smirnov S. L. Stenton S. Loipfinger C. Meng I. F. Scheller P. Freisinger R. Baski R. Berutti J. Behr M. Bucher F. Distelmaier E. Graf M. Gusic M. Hempel L. Kulterer J. Mayr T. Meitinger C. Mertes M. D. Metodiev A. Nadel A. Nasca A. Ohtake Y. Okazaki R. Olsen D. Piekutowska-Abramczuk A. R\u00f6tig R. Santer D. Schindler A. Slama C. Staufner T. Strom P. Verloo J.-C. von Kleist-Retzow S. B. Wortmann V. A. Y\u00e9pez C. Lamperti D. Ghezzi K. Murayama C. Ludwig J. Gagneur H. Prokisch Integration of proteomics with genomics and transcriptomics increases the diagnostic rate of Mendelian disorders. medRxiv 2021.03.09.21253187 [Preprint] (2021). https:\/\/doi.org\/10.1101\/2021.03.09.21253187.","DOI":"10.1101\/2021.03.09.21253187"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-025-01467-z"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06547-x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00978-w"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj1541"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06592-6"},{"key":"e_1_3_2_20_2","unstructured":"Genomics England \u201cThe 100 000 Genomes Project protocol\u201d (2017); https:\/\/figshare.com\/articles\/journal_contribution\/GenomicEnglandProtocol_pdf\/4530893\/4."},{"key":"e_1_3_2_21_2","unstructured":"Genomics England \u201cThe National Research Library Governance framework\u201d (2024); https:\/\/doi.org\/10.6084\/m9.figshare.4530893."},{"key":"e_1_3_2_22_2","first-page":"95","article-title":"EPIC-Norfolk: Study design and characteristics of the cohort. European Prospective Investigation of Cancer","volume":"80","author":"Day N.","year":"1999","unstructured":"N. Day, S. Oakes, R. Luben, K. T. Khaw, S. Bingham, A. Welch, N. Wareham, EPIC-Norfolk: Study design and characteristics of the cohort. European Prospective Investigation of Cancer. Br. J. Cancer 80, 95\u2013103 (1999).","journal-title":"Br. J. Cancer"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0528-2"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaz0274"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14134479"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.07.005"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.124"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.06.014"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06045-0"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2018.10.023"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.205"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012121148"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-015-3203-6"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1086\/376564"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.02.005"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00005.2017"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19356"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2019.07.011"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.318860"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1998.2081"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2639"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01894-5"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186780"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.09.003"},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","unstructured":"J. Janes M. Muller S. Selvaraj D. Manoel J. Stephenson C. Goncalves A. Lafita B. Polacco K. Obernier K. Alasoo M. C. Lemos N. Krogan M. Martin L. R. Saraiva D. Burke P. Beltrao Predicted mechanistic impacts of human protein missense variants. bioRxiv 2024.05.29.596373 [Preprint] (2024). https:\/\/doi.org\/10.1101\/2024.05.29.596373.","DOI":"10.1101\/2024.05.29.596373"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2020.05.012"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.5969"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092205"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44320-025-00158-6"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-019-0690-2"},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","unstructured":"J. Carrasco Zanini M. Pietzner M. Koprulu M. Zoodsma A. Williamson K. A. Hunt A. Manolias K. Walter Genes Health Iindustry Consortium Genes Health Reaserch Team H. C. Martin S. Finer D. A. van Heel C. Langenberg Proteomic and clinical impact of human knockouts in British South Asians. medRxiv 2025.10.15.25337977 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.10.15.25337977.","DOI":"10.1101\/2025.10.15.25337977"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03142-z"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27164-0"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2636-4"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.4c00586"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-025-02089-2"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44321-025-00309-0"},{"key":"e_1_3_2_59_2","doi-asserted-by":"crossref","unstructured":"C. C. Wu K. A. Tsantilas J. Park D. Plubell J. A. Sanders P. Naicker I. Govender S. Buthelezi S. Stoychev J. Jordaan G. Merrihew E. Huang E. D. Parker M. Riffle A. N. Hoofnagle W. S. Noble K. L. Poston T. J. Montine M. J. MacCoss Mag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome. bioRxiv 2023.06.10.544439 [Preprint] (2024). https:\/\/doi.org\/10.1101\/2023.06.10.544439.","DOI":"10.1101\/2023.06.10.544439"},{"key":"e_1_3_2_60_2","doi-asserted-by":"crossref","unstructured":"T. Huang J. Wang A. Stukalov M. K. R. Donovan S. Ferdosi L. Williamson S. Just G. Castro L. S. Cantrell E. Elgierari R. W. Benz Y. Huang K. Motamedchaboki A. Hakimi T. Arrey E. Damoc S. Kreimer O. C. Farokhzad S. Batzoglou A. Siddiqui J. E. Van Eyk D. Hornburg Protein coronas on functionalized nanoparticles enable quantitative and precise large-scale deep plasma Proteomics. bioRxiv 2023.08.28.555225 [Preprint] (2023). https:\/\/doi.org\/10.1101\/2023.08.28.555225.","DOI":"10.1101\/2023.08.28.555225"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2023.06.002"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2024.101199"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3036"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2025.102820"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102406"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-025-00660-y"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-024-09937-5"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-025-00655-9"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26620-1"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-00462-5"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.10.025"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2023.10.014"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0638-x"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.2.185"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm069"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg287"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5MB00663E"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aeb1331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:58:20Z","timestamp":1788976700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aeb1331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":77,"journal-issue":{"issue":"866","published-print":{"date-parts":[[2026,9,9]]}},"alternative-id":["10.1126\/scitranslmed.aeb1331"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aeb1331","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"2025-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaeb1331"}}