{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:59:17Z","timestamp":1790189957579,"version":"4.1.0"},"reference-count":105,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"868","funder":[{"name":"National Institute of Health","award":["HD088830"],"award-info":[{"award-number":["HD088830"]}]},{"name":"National Institute of Health","award":["HD098213"],"award-info":[{"award-number":["HD098213"]}]},{"name":"National Institute of Health","award":["HD108420"],"award-info":[{"award-number":["HD108420"]}]},{"name":"National Institute of Health","award":["HD094946"],"award-info":[{"award-number":["HD094946"]}]},{"name":"National Institute of Health","award":["HL164327"],"award-info":[{"award-number":["HL164327"]}]},{"name":"National Institute of Health","award":["HL128386"],"award-info":[{"award-number":["HL128386"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,9,23]]},"abstract":"<jats:p>\n                    At present, there are no US Food and Drug Administration (FDA)\u2013approved tocolytics for the management of preterm labor. To identify drugs for repurposing as tocolytics, a phenotypic high-throughput screen against a library of 1191 FDA-approved drugs was performed for inhibitors of in vitro uterine myometrial contractions. A total of 51 drugs inhibited calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) mobilization in primary human myometrial cells. To minimize potential off-target effects, hit drugs were counterscreened against primary human aortic vascular smooth muscle cells, identifying 10 uterine-selective drugs. Of these, two drugs, the antiemetic fosaprepitant dimeglumine and the glucocorticoid ciclesonide, displayed favorable in vitro therapeutic indices (TIs\u00a0&gt;\u00a05), inhibited contractions in human myometrial tissue ex vivo, and did not alter tone in the fetal murine ductus arteriosus ex vivo. Next, the potential synergy among hit drugs and clinically used tocolytics was evaluated using a high-throughput combination screen based on Ca\n                    <jats:sup>2+<\/jats:sup>\n                    mobilization in primary human myometrial cells. Four synergistic drug combinations incorporating ciclesonide, indomethacin, ivermectin, atosiban, or nelfinavir mesylate displayed favorable TIs of &gt;5 and improved ex vivo tocolytic potency, efficacy, or both. Last, aprepitant, ciclesonide, and four synergistic drug combinations delayed delivery until term and improved neonatal viability and skin and lung maturation in a mouse model of induced preterm labor, with several combinations outperforming their component drugs. This approach established a systematic strategy for identifying uterus-selective tocolytics, and these findings support further preclinical development of repurposed drugs and drug combinations for the treatment of preterm labor to improve pregnancy and neonatal outcomes.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aeb2020","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:00:29Z","timestamp":1790186429000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Drug repurposing identifies candidate uterus-selective tocolytics for preterm labor"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8698-1078","authenticated-orcid":true,"given":"Shajila","family":"Siricilla","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7105-0529","authenticated-orcid":true,"given":"Christopher J.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."},{"name":"Department of Pharmacology, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6278-4404","authenticated-orcid":true,"given":"Jeremy","family":"Staub","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0654-3401","authenticated-orcid":true,"given":"Jordan","family":"Walker","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3138-5307","authenticated-orcid":true,"given":"Alexus J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4723-2003","authenticated-orcid":true,"given":"Sydney E.","family":"Cole","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasmita","family":"De","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Hatcher","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Simpson","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4589-916X","authenticated-orcid":true,"given":"Jackson H.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7421-4741","authenticated-orcid":true,"given":"Naoko","family":"Boatwright","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1662-366X","authenticated-orcid":true,"given":"Stacey L.","family":"Crockett","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7920-772X","authenticated-orcid":true,"given":"Deanna C.","family":"Sekulich","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-6522","authenticated-orcid":true,"given":"Christian T.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7491-8672","authenticated-orcid":true,"given":"Vito","family":"Quaranta","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University, Nashville, TN, USA."},{"name":"Department of Biochemistry, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8951-9295","authenticated-orcid":true,"given":"Quanhu","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0930-1753","authenticated-orcid":true,"given":"John T.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6013-851X","authenticated-orcid":true,"given":"J M.","family":"Newton","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1183-8648","authenticated-orcid":true,"given":"Bibhash C.","family":"Paria","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-6146","authenticated-orcid":true,"given":"Jeff","family":"Reese","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-184X","authenticated-orcid":true,"given":"Jennifer L.","family":"Herington","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA."},{"name":"Department of Pharmacology, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization \u201cBorn too soon: Decade of action on preterm birth\u201d (Global report WHO 2023)."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00878-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31593-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1605566"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23580"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10244"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.6294"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251816"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.10.866"},{"key":"e_1_3_2_13_2","first-page":"89","article-title":"Prostaglandin receptors in lower segment myometrium during gestation and labor","volume":"93","author":"Brodt-Eppley J.","year":"1999","unstructured":"J. Brodt-Eppley, L. Myatt, Prostaglandin receptors in lower segment myometrium during gestation and labor. Obstet. Gynecol. 93, 89\u201393 (1999).","journal-title":"Obstet. Gynecol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6278592"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1015622"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2022.2053519"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2001.00010.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113477496"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.3c00361"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-022-08272-z"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","unstructured":"Z. Ahmad A. Rauf S. Naz H. A. Hemeg \u201cIntroduction to drug repurposing: Exploring new applications for existing drugs\u201d in Drug Development and Safety A. Rauf Ed. (IntechOpen 2024) 10.5772\/intechopen.113207.","DOI":"10.5772\/intechopen.113207"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.00051.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001711"},{"key":"e_1_3_2_24_2","unstructured":"World Health Organization WHO Recommendation on Tocolytic Therapy for Improving Preterm Birth Outcomes (WHO 2022)."},{"key":"e_1_3_2_25_2","first-page":"CD014978","article-title":"Tocolytics for delaying preterm birth: A network meta-analysis (0924)","volume":"8","author":"Wilson A.","year":"2022","unstructured":"A. Wilson, V. A. Hodgetts-Morton, E. J. Marson, A. D. Markland, E. Larkai, A. Papadopoulou, A. Coomarasamy, A. Tobias, D. Chou, O. T. Oladapo, M. J. Price, K. Morris, I. D. Gallos, Tocolytics for delaying preterm birth: A network meta-analysis (0924). Cochrane Database Syst. Rev. 8, CD014978 (2022).","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1570117"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908263410906"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq016"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.738261"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143243"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104268"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106876"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.2174\/138620710790596736"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw230"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2019.01.003"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90763-7"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70184-4"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.01.031"},{"key":"e_1_3_2_39_2","first-page":"922","article-title":"Mouse models of preterm birth: Suggested assessment and reporting guidelines","volume":"99","author":"McCarthy R.","year":"2018","unstructured":"R. McCarthy, C. Martin-Fairey, D. K. Sojka, E. D. Herzog, E. S. Jungheim, M. J. Stout, J. C. Fay, M. Mahendroo, J. Reese, J. L. Herington, E. J. Plosa, E. L. Shelton, S. K. England, Mouse models of preterm birth: Suggested assessment and reporting guidelines. Biol. Reprod. 99, 922\u2013937 (2018).","journal-title":"Biol. Reprod."},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2019.10.012"},{"key":"e_1_3_2_41_2","unstructured":"H. N. Simhan S. Caritis \u201cInhibition of acute preterm labor\u201d (UpToDate 2025); https:\/\/www.uptodate.com\/contents\/inhibition-of-acute-preterm-labor."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009871"},{"key":"e_1_3_2_43_2","unstructured":"Institute of Medicine Committee on Understanding Premature Birth and Assuring Healthy Outcomes Preterm Birth: Causes Consequences and Prevention R. E. Behrman A. S. Butler Eds. (National Academies Press 2007)."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2400601121"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells14211692"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31818718d2"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.5.7474"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0647"},{"key":"e_1_3_2_49_2","first-page":"222","article-title":"Bacteria-induced or bacterial product-induced preterm parturition in mice and rabbits is preceded by a significant fall in serum progesterone concentrations","volume":"7","author":"Fidel P. I.","year":"1998","unstructured":"P. I. Fidel Jr., R. Romero, E. Maymon, F. Hertelendy, Bacteria-induced or bacterial product-induced preterm parturition in mice and rabbits is preceded by a significant fall in serum progesterone concentrations. J. Matern. Fetal Med. 7, 222\u2013226 (1998).","journal-title":"J. Matern. Fetal Med."},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.6.R1415"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep34710"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.08.027"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.485"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00294.2023"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00259.2006"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199311253292202"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31077-x"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.02.010"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.247668"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/7.6.595"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph6060689"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1499091"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00590.x"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/941057"},{"key":"e_1_3_2_65_2","unstructured":"M. A. Ibrahim M. V. Pellegrini C. V. Preuss \u201cAntiemetic neurokinin-1 receptor blockers\u201d (StatPearls 2025); https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470394\/."},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.554766"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00593-9"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1380451"},{"key":"e_1_3_2_69_2","unstructured":"S. B. Graefe N. Rahimi S. S. Mohiuddin \u201cBiochemistry substance P\u201d (StatPearls 2025); https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554583\/."},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.187658"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10711"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod53.4.814"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.811584"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2024.06.004"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.03.003"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-024-02823-y"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105422"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1428520"},{"key":"e_1_3_2_79_2","first-page":"CD006169","article-title":"Combination of tocolytic agents for inhibiting preterm labour","volume":"2014","author":"Vogel J. P.","year":"2014","unstructured":"J. P. Vogel, J. M. Nardin, T. Dowswell, H. M. West, O. T. Oladapo, Combination of tocolytic agents for inhibiting preterm labour. Cochrane Database Syst. Rev. 2014, CD006169 (2014).","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.2478\/v10039-011-0019-x"},{"key":"e_1_3_2_81_2","first-page":"369","article-title":"The management of preterm labor with the calcium channel-blocking agent nifedipine combined with the beta-mimetic terbutaline","volume":"19","author":"Kaul A. F.","year":"1985","unstructured":"A. F. Kaul, R. Osathanondh, L. E. Safon, F. D. Frigoletto Jr., P. A. Friedman, The management of preterm labor with the calcium channel-blocking agent nifedipine combined with the beta-mimetic terbutaline. Drug Intell. Clin. Pharm. 19, 369\u2013371 (1985).","journal-title":"Drug Intell. Clin. Pharm."},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.4236\/ojog.2013.32047"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-008-8007-8"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2025.102574"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175346"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0911447"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105311"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e328363dfee"},{"key":"e_1_3_2_89_2","first-page":"1729","article-title":"Antitumorigenic action of nelfinavir: Effects on multiple myeloma and hematologic malignancies (review)","volume":"43","author":"Allegra A.","year":"2020","unstructured":"A. Allegra, V. Innao, A. G. Allegra, N. Pulvirenti, M. Pugliese, C. Musolino, Antitumorigenic action of nelfinavir: Effects on multiple myeloma and hematologic malignancies (review). Oncol. Rep. 43, 1729\u20131736 (2020).","journal-title":"Oncol. Rep."},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00704.2024"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2008.79.856"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000127440.68730.23"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30453-X"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2008.11.001"},{"key":"e_1_3_2_96_2","doi-asserted-by":"crossref","unstructured":"J. H. Rogers C. Martin-Fairey N. Boatwright A. J. Brown E. Charron S. Siricilla R. McCarthy S. K. England B. C. Paria A. Mahadevan-Jansen J. Reese J. L. Herington Restricted mating windows and thrombospondin 2 gene deletion improve the precision of parturition timing in mice. Biol. Reprod. 113 886\u2013893 (2025).","DOI":"10.1093\/biolre\/ioaf132"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.8.1541"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00337.2025"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.17.9759"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2008.08.002"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i15.2306"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.slasd.2025.100267"},{"key":"e_1_3_2_103_2","first-page":"281","article-title":"A comparative study of MTT and WST-1 assays in cytotoxicity analysis","volume":"61","author":"Sar\u0131 C.","year":"2021","unstructured":"C. Sar\u0131, S. Kolayl\u0131, F. C. Ey\u00fcpo\u011flu, A comparative study of MTT and WST-1 assays in cytotoxicity analysis. Haydarpa\u015fa Numune Med. J. 61, 281 (2021).","journal-title":"Haydarpa\u015fa Numune Med. J."},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2006.12.038"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00576-5"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.05.002"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aeb2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:00:47Z","timestamp":1790186447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aeb2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":105,"journal-issue":{"issue":"868","published-print":{"date-parts":[[2026,9,23]]}},"alternative-id":["10.1126\/scitranslmed.aeb2020"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aeb2020","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"2025-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaeb2020"}}