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Immunization with MPXV OPG153 elicited a potent neutralizing antibody response against MPXV and VACV in mice, substantiating OPG153 as both a promising vaccine antigen and a potent target for preventive and therapeutic antibodies.<\/jats:p>","DOI":"10.1126\/scitranslmed.aeb3840","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:58:18Z","timestamp":1765393098000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Antigen-agnostic identification of poxvirus broadly neutralizing antibodies targeting OPG153"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3564-9112","authenticated-orcid":true,"given":"Ida","family":"Paciello","sequence":"first","affiliation":[{"name":"Monoclonal Antibody Discovery (MAD) Laboratory, Fondazione Toscana Life Sciences, Siena 53100, 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