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Our findings confirm that a key pathophysiological feature of primary aldosteronism is disruption of corticosteroid rhythms rather than persistent elevation of hormones. We show that ambulatory dynamic hormone profiling is a viable technique that offers substantially more information than current diagnostic approaches relying on single\u2013time point hormone measurements. In the future, this offers the opportunity to investigate more subtle dynamic phenotypes and potentially earlier detection of disease.<\/jats:p>","DOI":"10.1126\/scitranslmed.aeb7517","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:00:27Z","timestamp":1787767227000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Tissue corticosteroid rhythms are dysregulated predominantly during sleep in primary aldosteronism"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9016-628X","authenticated-orcid":true,"given":"Marianne A.","family":"Grytaas","sequence":"first","affiliation":[{"name":"Department of Medicine, Haukeland University Hospital, 5021 Bergen, 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