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Transl. Med."],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:p>\n                    TAR DNA binding protein 43 (TDP-43) pathology is a defining pathological hallmark of multiple neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A major feature of TDP-43 pathology is its nuclear depletion, leading to the aberrant inclusion of cryptic exons during RNA splicing.\n                    <jats:italic toggle=\"yes\">STMN2<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">UNC13A<\/jats:italic>\n                    have emerged as prominent TDP-43 splicing targets, but the broader impact of TDP-43\u2013dependent cryptic splicing on neuronal function remains unclear. Here, we report previously unidentified TDP-43 splicing targets critical for membrane excitability and synaptic function, including\n                    <jats:italic toggle=\"yes\">KALRN<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">RAP1GAP<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">SYT7<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">KCNQ2<\/jats:italic>\n                    . Using human stem cell\u2013derived neurons, we showed that TDP-43 reduction induces cryptic splicing and down-regulation of these genes, resulting in impaired excitability and synaptic transmission. In postmortem brains from patients with FTD, these cryptic splicing events occurred selectively in neurons with TDP-43 pathology. Suppressing individual cryptic splicing events using antisense oligonucleotides partially restored neuronal function, and combined targeting almost fully rescued the synaptic deficit caused by TDP-43 loss. Together, our findings provide evidence that cryptic splicing in these synaptic and membrane excitability genes is not only a downstream marker but instead a direct driver of neuronal dysfunction, establishing a mechanistic link between TDP-43 pathology and neurodegeneration in ALS and FTD.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aeb8517","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:59:12Z","timestamp":1780509552000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":11,"title":["Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-9732","authenticated-orcid":true,"given":"Caiwei","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-482X","authenticated-orcid":true,"given":"Kuchuan","family":"Chen","sequence":"additional","affiliation":[{"name":"F.M. 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Zeng O. Sianto A. Lovchykova C. Liu T. Akiyama L. Petrucelli A. D. Gitler Nonsense-mediated decay masks cryptic splicing events caused by TDP-43 loss. bioRxiv 2025.07.09.664014 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.07.09.664014.","DOI":"10.1101\/2025.07.09.664014"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"I. R. Sinha Y. Ye Y. Li P. S. Sandal P. C. Wong S. Sun J. P. Ling Inhibition of nonsense-mediated decay in TDP-43 deficient neurons reveals novel cryptic exons. bioRxiv 2025.06.28.661837 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.06.28.661837.","DOI":"10.1101\/2025.06.28.661837"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","unstructured":"A.-L. Brown M. Zanovello A. Mikheenko D. Dattilo F. Pellegrini S. Bryce-Smith F. Mattedi P. R. Mehta J. N. S. Vargas NYGC ALS Consortium J. Humphrey M. J. Keuss P. Fratta Sensitivity to TDP-43 loss and degradation resistance determine cryptic exon biomarker potential. bioRxiv 2025.11.23.689722 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.11.23.689722.","DOI":"10.1101\/2025.11.23.689722"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0300-4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0293-z"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq5622"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04436-3"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04424-7"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.442"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/22768"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4364"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","unstructured":"M. J. Keuss P. Harley E. Ryadnov R. E. Jackson M. Zanovello O. G. Wilkins S. Barattucci P. R. Mehta M. G. Oliveira J. E. Parkes A. Sinha A. F. Correa-S\u00e1nchez P. L. Oliver E. M. C. Fisher G. Schiavo M. Shah J. Burrone P. Fratta Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs. bioRxiv 2024.06.20.599684 [Preprint] (2024). https:\/\/www.biorxiv.org\/content\/10.1101\/2024.06.20.599684v1.full.","DOI":"10.1101\/2024.06.20.599684"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.003"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08463-4"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-02096-w"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.95062.3"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab702"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2779"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2778"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.05.002"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.145306"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813263106"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.03.049"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00290-2"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.026"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.04.020"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5395.1890"},{"key":"e_1_3_2_37_2","first-page":"6058","article-title":"Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor","volume":"55","author":"Yee A.","year":"1995","unstructured":"A. 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Weckhuysen KCNQ2 loss-of-function variants disrupt neuronal maturation via early hyperexcitability followed by maladaptive network remodeling. bioRxiv 2025.07.22.664856 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.07.22.664856.","DOI":"10.1101\/2025.07.22.664856"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk2539"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad145"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-022-01408-6"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1942-8"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14952-3"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-023-02599-5"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-01995-0"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aeb8517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:59:28Z","timestamp":1780509568000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aeb8517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":60,"journal-issue":{"issue":"852","published-print":{"date-parts":[[2026,6,3]]}},"alternative-id":["10.1126\/scitranslmed.aeb8517"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aeb8517","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"assertion":[{"value":"2025-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaeb8517"}}