{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:02Z","timestamp":1792787222919,"version":"4.5.0"},"reference-count":95,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"869","funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["8056-00010A"],"award-info":[{"award-number":["8056-00010A"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002808","name":"Carlsbergfondet","doi-asserted-by":"publisher","award":["ID CF21-0363"],"award-info":[{"award-number":["ID CF21-0363"]}],"id":[{"id":"10.13039\/501100002808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF220C0080684"],"award-info":[{"award-number":["NNF220C0080684"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF21OC0071259"],"award-info":[{"award-number":["NNF21OC0071259"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Danish National Research Foundation","award":["DNRF164"],"award-info":[{"award-number":["DNRF164"]}],"id":[{"id":"https:\/\/ror.org\/00znyv691","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Independent Research Fund Denmark","award":["4285-00102B"],"award-info":[{"award-number":["4285-00102B"]}],"id":[{"id":"https:\/\/ror.org\/05svhj534","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:p>\n                    GATA2 (GATA binding protein 2) deficiency is a severe immunodeficiency caused by heterozygous variants in the gene encoding the transcription factor GATA2. Ex vivo gene editing of a patient\u2019s own CD34\n                    <jats:sup>+<\/jats:sup>\n                    hematopoietic stem and progenitor cells (HSPCs) could provide curative treatment. However, current methods that rely on nuclease-dependent editing face considerable challenges, including off-target effects, genotoxicity, and reduced engraftment potential. Here, we report the development of an efficient gene editing therapy for GATA2 deficiency using prime editing with a favorable safety profile in terms of off-target effects and genotoxicity. We used prime editing to correct a\n                    <jats:italic toggle=\"yes\">GATA2<\/jats:italic>\n                    c.956_962del variant in patient-derived CD34\n                    <jats:sup>+<\/jats:sup>\n                    HSPCs, reaching up to 70% prime editing efficiency and an increase in functional\n                    <jats:italic toggle=\"yes\">GATA2<\/jats:italic>\n                    alleles from 50 to 77%. We demonstrate that prime-edited patient HSPCs showed increased engraftment potential compared with untreated cells and detected limited on-target genotoxicity and no off-target editing at the top 20 predicted sites. Short prestimulation of CD34\n                    <jats:sup>+<\/jats:sup>\n                    HSPCs supported efficient prime editing while preserving stemness, mitigating p53 activation, and increasing multilineage engraftment. We report PASSIGE (prime editing\u2013assisted site-specific integrase gene editing) in CD34\n                    <jats:sup>+<\/jats:sup>\n                    HSPCs, developing a more broadly applicable, double-strand break\u2013independent complementary DNA insertion strategy with the potential to address a large proportion of alleles causing GATA2 deficiency. Together, our results demonstrate the preclinical development of prime editing\u2013based therapies for GATA2 deficiency in CD34\n                    <jats:sup>+<\/jats:sup>\n                    HSPCs.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aec7031","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:33Z","timestamp":1790791113000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Prime editing of human hematopoietic stem cells for correction of GATA2 deficiency"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5690-7603","authenticated-orcid":true,"given":"Jonas H.","family":"Wolff","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0959-880X","authenticated-orcid":true,"given":"Thomas W.","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie R.","family":"Dorset","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6579-5278","authenticated-orcid":true,"given":"Janni","family":"Sjelborg","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3921-0921","authenticated-orcid":true,"given":"Sujan","family":"Ravendran","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-0259","authenticated-orcid":true,"given":"Anne Louise S.","family":"Revenfeld","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9890-5814","authenticated-orcid":true,"given":"Didde","family":"Haslund","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7942-2780","authenticated-orcid":true,"given":"Ana\u00efs Marie","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-4056","authenticated-orcid":true,"given":"Mette","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark."},{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-7531","authenticated-orcid":true,"given":"Martin K.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1853-9704","authenticated-orcid":true,"given":"Trine H.","family":"Mogensen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."},{"name":"Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2808-4755","authenticated-orcid":true,"given":"Bjarne K.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7383-0297","authenticated-orcid":true,"given":"Rasmus O.","family":"Bak","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1322-3209","authenticated-orcid":true,"given":"Jacob Giehm","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-356352"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-515528"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15947"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.24271"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/371221a0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031556"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130751"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2011.04.007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-687889"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.913"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-021-01189-y"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.08.004"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-365049"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.01.030"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01374-y"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19691"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-669937"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20134"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-683235"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah3480"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.103"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202013545"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan0820"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09614-y"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17626-2"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01284-y"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001996"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40348-018-0086-1"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.04.001"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf2444"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-20909-x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2025.07.038"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku402"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt714"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2623"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.02.019"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0551-y"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.09.001"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0049-z"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4192"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102157"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-188963"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1711-4"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.09.018"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01039-7"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-023-01026-0"},{"key":"e_1_3_2_48_2","first-page":"2085","article-title":"In vivo HSC prime editing rescues sickle cell disease in a mouse model","volume":"141","author":"Li C.","year":"2023","unstructured":"C. Li, A. Georgakopoulou, G. A. Newby, P. J. Chen, K. A. Everette, K. Paschoudi, E. Vlachaki, S. Gil, A. K. Anderson, T. Koob, L. Huang, H. Wang, H.-P. Kiem, D. R. Liu, E. Yannaki, A. Lieber, In vivo HSC prime editing rescues sickle cell disease in a mouse model. Blood 141, 2085\u20132099 (2023).","journal-title":"Blood"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024028166"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2509807"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-024-01233-3"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01915-4"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34045-7"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101823"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62738-2"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.02.022"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba8853"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07259-6"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-025-02771-8"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-380634"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001228"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.5MA0815-388R"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.143"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0152-0"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02508-z"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.09.013"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.10.018"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02266-4"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12719"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.02.002"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02488-6"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.03.006"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-024-01277-5"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1534-x"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-024-01227-1"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15051590"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01133-w"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2025.101490"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.11.001"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01527-4"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005538"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-026-10241-z"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2023.02.014"},{"key":"e_1_3_2_84_2","unstructured":"K. Clement H. Rees M. C. Canver J. M. Gehrke R. Farouni J. Y. Hsu M. A. Cole D. R. Liu J. K. Joung D. E. Bauer L. Pinello K. Clement H. Rees M. C. Canver J. M. Gehrke R. Farouni J. Y. Hsu M. A. Cole D. R. Liu J. K. Joung D. E. Bauer L. Pinello CRISPResso2 v2.3.4 Zenodo (2026); https:\/\/zenodo.org\/doi\/10.5281\/zenodo.20824834."},{"key":"e_1_3_2_85_2","unstructured":"G. H. Hwang B. Vyshedskiy T. Barry J. Zeng J. P. Manis A. Shimamura D. E. Bauer L. Pinello G. H. Hwang B. Vyshedskiy T. Barry J. Zeng J. P. Manis A. Shimamura D. E. Bauer L. Pinello CRISPRlungo v0.1 Zenodo (2026); https:\/\/zenodo.org\/doi\/10.5281\/zenodo.20824854."},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.001"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab427"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3437"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.275607.121"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9170-9_7"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.301"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01570"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1089\/hgtb.2011.034"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5393.1497"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0032-3"},{"key":"e_1_3_2_96_2","doi-asserted-by":"crossref","unstructured":"G. H. Hwang B. Vyshedskiy T. Barry J. Zeng J. P. Manis A. Shimamura D. E. Bauer L. Pinello Analyzing long-read CRISPR experiments with CRISPRLungo. bioRxiv 2025.10.21.683786 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.10.21.683786.","DOI":"10.1101\/2025.10.21.683786"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aec7031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:50Z","timestamp":1790791130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aec7031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":95,"journal-issue":{"issue":"869","published-print":{"date-parts":[[2026,9,30]]}},"alternative-id":["10.1126\/scitranslmed.aec7031"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aec7031","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2025-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaec7031"}}