{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:04:17Z","timestamp":1791342257601,"version":"4.3.1"},"reference-count":77,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"844","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82192890"],"award-info":[{"award-number":["82192890"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102889"],"award-info":[{"award-number":["82102889"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373191"],"award-info":[{"award-number":["82373191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25C2043"],"award-info":[{"award-number":["U25C2043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"crossref","award":["CSTB2023NSCQ-JQX0009"],"award-info":[{"award-number":["CSTB2023NSCQ-JQX0009"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Innovation Key R&D","award":["CSTB2024TIAD-STX0045"],"award-info":[{"award-number":["CSTB2024TIAD-STX0045"]}]},{"name":"Municipal Health Commission of Chongqing","award":["HBRC202408"],"award-info":[{"award-number":["HBRC202408"]}]},{"name":"Chongqing Scientific and Technological Commission","award":["2023CCXM001"],"award-info":[{"award-number":["2023CCXM001"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,4,8]]},"abstract":"<jats:p>Both primary and metastatic brain malignancies are fatal and highly infiltrated with tumor-associated macrophages (TAMs). Enhancing the phagocytosis of neoplastic cells by TAMs is pivotal for slowing tumor growth. Great endeavors have been made to develop tyrosine kinase inhibitors (TKIs) for brain malignancies, yet whether tumor-targeting TKIs affect the phagocytic capacity of TAMs remains largely unknown. In this preclinical study, we report that repurposing ibrutinib, a blood-brain barrier\u2013penetrable TKI, effectively suppresses the growth of several primary and metastatic brain tumors highly expressing Bruton\u2019s tyrosine kinase (BTK) or bone marrow X-linked nonreceptor tyrosine kinase (BMX) but concurrently dampens the TAM phagocytic function. Mechanistically, BTK, which is activated in TAMs, interacts with and phosphorylates Wiskott-Aldrich syndrome protein (WASp) to organize the actin cytoskeleton, which is imperative for phagocytosis. Ibrutinib treatment disrupts BTK-mediated WASp activation, thereby compromising TAM phagocytic efficacy. Pharmacological activation of WASp by its selective small-molecular activator EG-011 restores the ibrutinib-impaired TAM engulfment of tumor cells and effectively improves ibrutinib efficacy in mice bearing glioblastomas, primary central nervous system lymphomas, and lung carcinoma brain metastases. Furthermore, elevated expression of phosphorylated BTK or phosphorylated WASp in TAMs correlates with an increased phagocytic TAM subset identified by single-cell RNA sequencing and correlates with prolonged patient survival in a cohort with glioblastoma. Our preclinical study highlights the necessity of evaluating the on-target, off-tumor attack of TAMs during TKI administration and provides a proof of concept for reinvigorating the TAM phagocytic function to achieve additional clinical benefit.<\/jats:p>","DOI":"10.1126\/scitranslmed.aed1155","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:59:41Z","timestamp":1775671181000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacological activation of WASp potentiates macrophage phagocytosis and enhances ibrutinib efficacy against mouse models of brain tumors"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4511-7672","authenticated-orcid":true,"given":"Yue","family":"Cheng","sequence":"first","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8449-6589","authenticated-orcid":true,"given":"Tianran","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."},{"name":"Shigatse Branch, Xinqiao Hospital, Army Medical University, Chongqing 857000, Tibet Autonomous Region, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2791-4040","authenticated-orcid":true,"given":"Mengru","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8004-9446","authenticated-orcid":true,"given":"Chuan","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Army Medical University, Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhen","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."},{"name":"School of Medicine, Chongqing University, Chongqing 400030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Army Medical University, Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujing","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehao","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0460-5632","authenticated-orcid":true,"given":"Tunan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Army Medical University, Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Mao","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianying","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Southwest Hospital, Army Medical University, Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyue","family":"Qi","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Duan","sequence":"additional","affiliation":[{"name":"Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-1940","authenticated-orcid":true,"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanghui","family":"Ye","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikai","family":"Kong","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Niu","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Qin","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yan","sequence":"additional","affiliation":[{"name":"Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-1486","authenticated-orcid":true,"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3916-186X","authenticated-orcid":true,"given":"Rong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Army Medical University, Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Army Medical University, Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0699-8401","authenticated-orcid":true,"given":"Yi-Fang","family":"Ping","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."},{"name":"Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4383-0197","authenticated-orcid":true,"given":"Xiu-Wu","family":"Bian","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."},{"name":"Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3380-4545","authenticated-orcid":true,"given":"Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of Pathology &amp; Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China."},{"name":"Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00921-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0232-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01267-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02124-y"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-333492"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.007"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22396"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1807315"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02018"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.70053"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.02.009"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0224-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30649-1"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-1871"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.038"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.04.012"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-00920-9"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52500-5"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00682-X"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0779-z"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1475"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0600-7"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah6816"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-024-01763-6"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-020-03580-y"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00691-z"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203346200"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00354-5"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.01.036"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05124-2"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1101"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.007"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.12.043"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16164-1"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002088"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0750-6"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-023-00559-7"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.03.025"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.03.013"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-1694"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28372-y"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003446"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221472"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2018-0637"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2019.1689959"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd4550"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08188-4"},{"key":"e_1_3_2_49_2","first-page":"3602","article-title":"A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers","volume":"109","author":"Spriano F.","year":"2024","unstructured":"F. Spriano, G. Sartori, J. Sgrignani, L. Barnabei, A. J. Arribas, M. Guala, A. M. C. Del Amor, M. R. Tomasso, C. Tarantelli, L. Cascione, G. Golino, M. E. Riveiro, R. Bortolozzi, A. Lupia, F. Paduano, S. Huguet, K. Rezai, A. Rinaldi, F. Margheriti, P. Ventura, G. Guarda, G. Costa, R. Rocca, A. Furlan, L. M. Verdonk, P. Innocenti, N. I. Martin, G. Viola, C. Driessen, E. Zucca, A. Stathis, D. Gahtory, M. van den Nieuwboer, B. Bornhauser, S. Alcaro, F. Trapasso, S. Cristobal, S. B. Padrick, N. Pazzi, F. Cavalli, A. Cavalli, E. Gaudio, F. Bertoni, A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers. Haematologica 109, 3602\u20133614 (2024).","journal-title":"Haematologica"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12212"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.010"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70304"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00437-8"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1678-1"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01478-6"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02391-8"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08633-8"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw7843"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01323-8"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.03.055"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00267-9"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0124-z"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1456-0"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.07.008"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02177-7"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-025-01039-5"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15080"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.03.004"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.5984"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.2c01956"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01625-x"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03150-z"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12151970"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101582"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0501"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0195-y"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0969-x"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0312-x"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aed1155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:59:48Z","timestamp":1775671188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aed1155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,8]]},"references-count":77,"journal-issue":{"issue":"844","published-print":{"date-parts":[[2026,4,8]]}},"alternative-id":["10.1126\/scitranslmed.aed1155"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aed1155","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,8]]},"assertion":[{"value":"2025-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaed1155"}}