{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:59:17Z","timestamp":1790189957588,"version":"4.1.0"},"reference-count":113,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"868","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571506"],"award-info":[{"award-number":["32571506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22376174"],"award-info":[{"award-number":["22376174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Fujian Province, China","award":["2025J010004"],"award-info":[{"award-number":["2025J010004"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,9,23]]},"abstract":"<jats:p>\n                    The prevalence of hyperuricemia (HUA) is increasing annually and now affects \u223c14% of the population. Uric acid (UA) is the end product of purine metabolism in humans. Either increased production or reduced excretion of UA can induce HUA. Here, we identified RAS and RAB interactor\u2013like (RINL) as a regulator of renal UA excretion and conducted a screen for compounds capable of lowering serum UA concentrations. We found that the\n                    <jats:italic toggle=\"yes\">human RINL<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">hRINL<\/jats:italic>\n                    ) Pro\n                    <jats:sup>139<\/jats:sup>\n                    \u2192Ser (P139S) mutation was pathogenic for HUA in a familial pedigree. As a guanine nucleotide exchange factor, RINL activated RAB5C in renal tubular epithelial cells. Activated RAB5C promoted the endocytosis and lysosomal degradation of the UA transporter ATP-binding cassette subfamily G member 2, thereby inhibiting renal UA excretion and contributing to the development of HUA. The hRINL (P139S) mutation inhibited proteasome-mediated degradation of hRINL in renal tubular epithelial cells, causing its accumulation, and the homologous\n                    <jats:italic toggle=\"yes\">mouse RINL<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">mRINL<\/jats:italic>\n                    ) Pro\n                    <jats:sup>140<\/jats:sup>\n                    \u2192Ser (P140S) mutation up-regulated mRINL in mouse kidneys, indicating a gain-of-function mutation. We screened a library of 1500 natural products for RINL inhibitors and, after experimental validation, found that tetrahydrocurcumin bound to RINL and promoted its degradation, thereby ameliorating HUA induced by potassium oxonate treatment,\n                    <jats:italic toggle=\"yes\">uricase<\/jats:italic>\n                    knockout, or secondary to severe malaria and chronic kidney disease in mice. These findings establish RINL as a repressor of UA excretion in both humans and mice and suggest that targeted degradation of RINL represents a promising strategy for HUA treatment.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aed1866","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:00:29Z","timestamp":1790186429000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["The guanine nucleotide exchange factor Rin-like is a repressor for renal uric acid excretion in human and mouse"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7247-7751","authenticated-orcid":true,"given":"Changshun","family":"Han","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9614-103X","authenticated-orcid":true,"given":"Chengyong","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."},{"name":"State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0209-9289","authenticated-orcid":true,"given":"Weiping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xiamen Key Laboratory of Precision Diagnosis and Treatment of Chronic Kidney Disease, Fujian Clinical Research Center for Chronic Glomerular Disease, First Affiliated Hospital of Xiamen University, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361103, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-2708","authenticated-orcid":true,"given":"Xiaoyan","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiao","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihao","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuni","family":"Zhuang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2012-9617","authenticated-orcid":true,"given":"Tianyun","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8511-0747","authenticated-orcid":true,"given":"Zixuan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4036-1284","authenticated-orcid":true,"given":"Fengkai","family":"Ruan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhen","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fucong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitao","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-3647","authenticated-orcid":true,"given":"Chunyan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-9930","authenticated-orcid":true,"given":"Baoding","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."},{"name":"State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7453-7391","authenticated-orcid":true,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgui","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-0200","authenticated-orcid":true,"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6397-2785","authenticated-orcid":true,"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-0101","authenticated-orcid":true,"given":"Chensong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9354-5864","authenticated-orcid":true,"given":"Xianming","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."},{"name":"State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-3033","authenticated-orcid":true,"given":"Zhenghong","family":"Zuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China."},{"name":"State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.06.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.05.011"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.09.011"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2023.10.005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.02.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154868"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2070391"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.03.029"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101690"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c01260"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50752-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1897211"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c06297"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.06.042"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2022.11.003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.04.031"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.02.003"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.791983"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-024-01826-9"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153850"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156622"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.140462"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102108"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2025.116770"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103546"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0441-1"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.12.030"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021113-170343"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06620-4"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2022.118977"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-48"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12039"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2019.06.001"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s10038-020-0821-z"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1756"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60480-3"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56843-5"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16525-w"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-024-00708-6"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.9.1451"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-14357-5"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1002"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom13101519"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01921-5"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01916-y"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11480821"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.42499"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154521"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409126"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.03.009"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197714050-00002"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2024.04.017"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32234-0"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710895"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.221575"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221466"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42344"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.33007"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107485"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.04.007"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det085"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2018.10.012"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021050616"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310492"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.10.030"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.43118"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415041"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.24.321"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-013-0806-8"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.137112"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000427"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00569-9"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49420-9"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030575"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000696"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.01.014"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0222-x"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0174-z"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2022.06.022"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00542-w"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-025-21440-0"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-83126-8"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03430-8"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00267-3"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2019.04.003"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02497-0"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.12.009"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.128665"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29208-w"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253852"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0334-3"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.41779"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47805-4"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129057"},{"key":"e_1_3_2_96_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41584-019-0347-y","article-title":"LDHD mutation leads to hyperuricaemia and gout","volume":"16","author":"Onuora S.","year":"2020","unstructured":"S. Onuora, LDHD mutation leads to hyperuricaemia and gout. Nat. Rev. Rheumatol. 16, 2 (2020).","journal-title":"Nat. Rev. Rheumatol."},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-2007-7"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep03755"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.08.001"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157084"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c07209"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217309"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-021-01020-y"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050373"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24209"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-01006-3"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.04.025"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156974"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156674"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.11.004"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-42217-8"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054481"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046424"},{"key":"e_1_3_2_114_2","first-page":"E374","article-title":"Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii","volume":"108","author":"Li J.","year":"2011","unstructured":"J. Li, S. Pattaradilokrat, F. Zhu, H. Jiang, S. Liu, L. Hong, Y. Fu, L. Koo, W. Xu, W. Pan, J. M. Carlton, O. Kaneko, R. Carter, J. C. Wootton, X. Z. Su, Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii. Proc. Natl. Acad. Sci. U.S.A. 108, E374\u2013E382 (2011).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aed1866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:00:55Z","timestamp":1790186455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aed1866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":113,"journal-issue":{"issue":"868","published-print":{"date-parts":[[2026,9,23]]}},"alternative-id":["10.1126\/scitranslmed.aed1866"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aed1866","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"2025-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaed1866"}}