{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:35:09Z","timestamp":1787866509390,"version":"build-2784847793"},"reference-count":55,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"853","funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","award":["NPRP11S-0121-180351"],"award-info":[{"award-number":["NPRP11S-0121-180351"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut national de la sant\u00e9 et de la recherche m\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ANR","award":["TERMM ANR-20-CE92-0001"],"award-info":[{"award-number":["TERMM ANR-20-CE92-0001"]}]},{"name":"ANR","award":["ANR-24-RRII-0005"],"award-info":[{"award-number":["ANR-24-RRII-0005"]}]},{"name":"ANR","award":["France 2030 ANR-24-RRII-0005"],"award-info":[{"award-number":["France 2030 ANR-24-RRII-0005"]}]},{"DOI":"10.13039\/501100015760","name":"INSERM-Transfert","doi-asserted-by":"crossref","award":["copoc"],"award-info":[{"award-number":["copoc"]}],"id":[{"id":"10.13039\/501100015760","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004099","name":"La Ligue Contre Le Cancer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SIRIC"},{"name":"Transcan ERAnet"},{"name":"CAncer Research for PErsonalised Medicine"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,6,10]]},"abstract":"<jats:p>Early cancer detection and prophylactic intervention remain the primary strategies for reducing colorectal carcinoma incidence and mortality. Although the immune microenvironment and tumor-associated antigens have been shown to play a pivotal role in carcinogenesis, the factors shaping immune dynamics during the premalignant phase remain poorly understood. In this study, we performed a comprehensive multimodal characterization of the immune microenvironment in 258 longitudinal premalignant colorectal lesions. Using a discovery cohort of 135 lesions from 26 patients stratified by low versus high polyp development rate, we identified distinct immune states associated with polyp burden. These findings were validated in an independent cohort of 123 lesions from 43 patients. Lesions from patients with low polyp development rates exhibited signatures of robust immune surveillance characterized by enhanced adaptive immune infiltration, including defined T cell subsets, and a higher prevalence of mature tertiary lymphoid structures compared with lesions from patients with high polyp frequency. These immune features were accompanied by increased expression of noncoding RNAs. These transcripts were predicted to encode noncanonical antigens with high MHC-I (major histocompatibility complex class I) binding affinity, potentially increasing lesion immunogenicity. We propose that early carcinogenesis is shaped by the immune microenvironment in association with noncoding RNAs, revealing potential early biomarkers in individuals at high risk of developing colorectal cancer.<\/jats:p>","DOI":"10.1126\/scitranslmed.aed2424","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:58:11Z","timestamp":1781114291000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Immune microenvironment and noncoding RNA shape early colorectal carcinogenesis in patients with premalignant lesions"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-8770","authenticated-orcid":true,"given":"Erwan","family":"Morgand","sequence":"first","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1405-4785","authenticated-orcid":true,"given":"Marc","family":"Van den Eynde","sequence":"additional","affiliation":[{"name":"Institut Roi Albert II, Department of Medical Oncology Cliniques Universitaires St-Luc and Institut de Recherche Clinique et Experimentale (Pole MIRO), Universit\u00e9 Catholique de Louvain, 1200 Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3609-198X","authenticated-orcid":true,"given":"Ha","family":"Nguyen","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5106-7749","authenticated-orcid":true,"given":"Anne-Fran\u00e7oise","family":"Batto","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3345-1030","authenticated-orcid":true,"given":"Bernhard","family":"Mlecnik","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5672-6685","authenticated-orcid":true,"given":"Pamela","family":"Baldin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cliniques Universitaires St-Luc and Institut de Recherche Clinique et Experimentale (Pole GAEN) Universit\u00e9 Catholique de Louvain, 1200 Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4692-1093","authenticated-orcid":true,"given":"Amine","family":"Majdi","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4800-3314","authenticated-orcid":true,"given":"Tessa","family":"Fredriksen","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3692-8524","authenticated-orcid":true,"given":"Lucie","family":"Lafontaine","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6013-6645","authenticated-orcid":true,"given":"Gabriela","family":"Bindea","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariza","family":"Mezine","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U970 PARCC, Paris Institute for Transplantation and Organ Regeneration, 75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6567-8204","authenticated-orcid":true,"given":"Mohammad","family":"Shararah","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-3820","authenticated-orcid":true,"given":"Angela","family":"Vasaturo","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assia","family":"Hijazi","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Buttard","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4854-2362","authenticated-orcid":true,"given":"Pauline","family":"Maby","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1249-4733","authenticated-orcid":true,"given":"Rodrigo Nalio","family":"Ramos","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5088-1757","authenticated-orcid":true,"given":"Paula","family":"Gragera","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0531-5207","authenticated-orcid":true,"given":"Amos","family":"Kirilovsky","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Immunomonitoring Platform, Laboratory of Immunology, Georges Pompidou European Hospital, 75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7755-6689","authenticated-orcid":true,"given":"Carine","family":"El Sissy","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Immunomonitoring Platform, Laboratory of Immunology, Georges Pompidou European Hospital, 75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Marliot","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Immunomonitoring Platform, Laboratory of Immunology, Georges Pompidou European Hospital, 75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2083-610X","authenticated-orcid":true,"given":"Franck","family":"Pag\u00e8s","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Immunomonitoring Platform, Laboratory of Immunology, Georges Pompidou European Hospital, 75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-3185","authenticated-orcid":true,"given":"Fazulur Rehaman","family":"Vempalli","sequence":"additional","affiliation":[{"name":"Sidra Medicine, P.O. Box 26999, Doha, Qatar."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-5092","authenticated-orcid":true,"given":"Wouter","family":"Hendrickx","sequence":"additional","affiliation":[{"name":"Sidra Medicine, P.O. Box 26999, Doha, Qatar."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-6349","authenticated-orcid":true,"given":"Tariq","family":"Masoodi","sequence":"additional","affiliation":[{"name":"Sidra Medicine, P.O. Box 26999, Doha, Qatar."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4702-6617","authenticated-orcid":true,"given":"Michele","family":"Ceccarelli","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, University of Miami, Miami, FL 33136, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5857-773X","authenticated-orcid":true,"given":"Davide","family":"Bedognetti","sequence":"additional","affiliation":[{"name":"Sidra Medicine, P.O. Box 26999, Doha, Qatar."},{"name":"Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-1339","authenticated-orcid":true,"given":"J\u00e9r\u00f4me","family":"Galon","sequence":"additional","affiliation":[{"name":"INSERM, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France."},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, F-75006 Paris, France."},{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3397"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-15-0406"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1107773"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00274-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0285-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2201445"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-018-0007-y"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.12.018"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3909"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-0422"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau5516"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abm6359"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.1912250"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1330-0"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-2929"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01088-x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.11.031"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327608"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-018-0642-z"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32319-0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314005"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0605-3264"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(00)70444-5"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02177-1"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.4.257"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3967"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30789-X"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac812"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.07.008"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129139"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15020418"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0264-x"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.018"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.4161\/onci.27456"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.1919377"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad6352"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16166"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy337"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29027-8"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-3298"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.06.039"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp698"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx193"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi1110s43"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-021-03995-y"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.239244.118"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r106"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16747-x"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3560"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.12.7256"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.03.007"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1914-8"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2014.09.006"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aed2424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:58:20Z","timestamp":1781114300000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aed2424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":55,"journal-issue":{"issue":"853","published-print":{"date-parts":[[2026,6,10]]}},"alternative-id":["10.1126\/scitranslmed.aed2424"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aed2424","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]},"assertion":[{"value":"2025-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaed2424"}}