{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:55:26Z","timestamp":1793166926060,"version":"4.5.0"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"869","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002529"],"award-info":[{"award-number":["UL1TR002529"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA082709"],"award-info":[{"award-number":["P30CA082709"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK107623"],"award-info":[{"award-number":["R01-DK107623"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54-DK137328"],"award-info":[{"award-number":["U54-DK137328"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AI148282"],"award-info":[{"award-number":["R01-AI148282"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1TR004402"],"award-info":[{"award-number":["UM1TR004402"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10-1S10OD03639-01"],"award-info":[{"award-number":["S10-1S10OD03639-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK079337"],"award-info":[{"award-number":["P30DK079337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["NHGRI R25HG012325"],"award-info":[{"award-number":["NHGRI R25HG012325"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["R01-DK138504"],"award-info":[{"award-number":["R01-DK138504"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Affairs Merit","award":["BX002901"],"award-info":[{"award-number":["BX002901"]}]},{"DOI":"10.13039\/100010249","name":"School of Medicine, Indiana University","doi-asserted-by":"publisher","award":["INGEN4DS"],"award-info":[{"award-number":["INGEN4DS"]}],"id":[{"id":"10.13039\/100010249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["ISAC-DK128851"],"award-info":[{"award-number":["ISAC-DK128851"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019268","name":"Showa University","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100019268","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation Flanders","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"ISTH Training Fellowship","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:p>\n                    Methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MRSA) bacteremia causes substantial morbidity, but tissue reservoirs that permit bacterial persistence remain poorly defined. Using intravenous USA300 MRSA infection in mice, multiplexed imaging, dual-species transcriptomics, host and bacterial genetics, and cell-based assays, we uncovered the renal inner medulla, the site of urine concentration, as an MRSA reservoir. In this hyperosmotic niche, MRSA evaded immune detection and co-opted tissue polyamines to sustain growth, enabling subsequent spread toward the renal cortex. Neutrophil recruitment to the inner medulla was profoundly delayed owing to osmotic inhibition of immune cell migration. Disruption of medullary osmolality with the loop diuretic furosemide accelerated neutrophil infiltration, limited bacterial spread, and improved renal outcomes. Mechanistically, polyamines promoted MRSA persistence through both extracellular and intracellular actions that depended on local osmolality and pH. In the medullary milieu, polyamines primarily associated with the bacterial surface and stabilized membranes against osmotic stress. Intracellular polyamines enhanced translation of\n                    <jats:italic toggle=\"yes\">guaB<\/jats:italic>\n                    (inosine monophosphate dehydrogenase), the rate-limiting enzyme in bacterial de novo purine biosynthesis. The polyamine-catabolizing gene\n                    <jats:italic toggle=\"yes\">speG<\/jats:italic>\n                    (spermidine acetyltransferase), uniquely present in epidemic USA300 MRSA strains, mitigated polyamine toxicity and conferred a selective advantage in the polyamine-rich kidney. These findings revealed the inner medulla as a physiologically immune-restricted MRSA reservoir and supported modulation of medullary osmolality and bacterial polyamine metabolism as candidate adjunctive strategies for limiting renal persistence and dissemination during MRSA bacteremia.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aed4200","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:33Z","timestamp":1790791113000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Hyperosmotic niche adaptation and tissue polyamines underlie MRSA persistence in the kidney"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6111-8027","authenticated-orcid":true,"given":"Nobuhiro","family":"Kanazawa","sequence":"first","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2890-7072","authenticated-orcid":true,"given":"Caroline P.","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."},{"name":"Department of Cardiovascular Sciences, KU Leuven, Leuven 3000, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-0435","authenticated-orcid":true,"given":"Shinichi","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7385-1293","authenticated-orcid":true,"given":"Segewkal Hawaze","family":"Heruye","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Zollman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2760-8692","authenticated-orcid":true,"given":"Jered","family":"Myslinski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"White","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8512-9238","authenticated-orcid":true,"given":"Chetan","family":"Poudel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."},{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6280-3164","authenticated-orcid":true,"given":"Jodi","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0284-0631","authenticated-orcid":true,"given":"Farooq","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Diabetes Immunology, City of Hope, Los Angeles, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-0873","authenticated-orcid":true,"given":"Bernhard","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7871-8141","authenticated-orcid":true,"given":"Yinghua","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1408-596X","authenticated-orcid":true,"given":"Bill","family":"Bowen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4645-3614","authenticated-orcid":true,"given":"Tarek M.","family":"El-Achkar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4160-8463","authenticated-orcid":true,"given":"Patrick C","family":"McGuire","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2699-626X","authenticated-orcid":true,"given":"Yunlong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7552-9957","authenticated-orcid":true,"given":"Kyle","family":"McCrocklin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Informatics, Indiana University Luddy School of Informatics, Computing, and Engineering, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2260-4310","authenticated-orcid":true,"given":"Juexin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Informatics, Indiana University Luddy School of Informatics, Computing, and Engineering, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Hirakochi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Juntendo University, Chiba 2790021, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-0227","authenticated-orcid":true,"given":"Tomohiko","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Juntendo University, Chiba 2790021, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-2851","authenticated-orcid":true,"given":"Taeok","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, Northwest, IN 46408, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-6107","authenticated-orcid":true,"given":"Kimberly","family":"Martinod","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, KU Leuven, Leuven 3000, Belgium."},{"name":"Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Fey","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3321-5561","authenticated-orcid":true,"given":"Pierre C.","family":"Dagher","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0446-6575","authenticated-orcid":true,"given":"Takashi","family":"Hato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA."},{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA."},{"name":"Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01867-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2024.06.017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-021-04391-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000809"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1932.02730350023006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/499815"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02183-15"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-018-1164-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.05.035"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI180117"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.TM118.005670"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07809.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.11.012"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/medsci10030040"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14145"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00613-24"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00889-13"},{"key":"e_1_3_2_19_2","first-page":"e1219","article-title":"Association of causative pathogens with acute kidney injury in adult patients with community-onset sepsis","volume":"7","author":"Pant P.","year":"2025","unstructured":"P. Pant, S. Chihara, V. Krishnamoorthy, M. M. Treggiari, J. A. Messina, J. R. Privratsky, K. Raghunathan, T. Ohnuma, Association of causative pathogens with acute kidney injury in adult patients with community-onset sepsis. Crit. Care Explor. 7, e1219 (2025).","journal-title":"Crit. Care Explor."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.800532"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab158"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI123284"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2022060644"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62270"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.02.027"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00519771"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90824-0"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)71444-9"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22973-9"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05688-9"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2024414118"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008080843"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000868"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adu0351"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007112"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)27820-X"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.359"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374794"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2009.03.008"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan2788"},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","unstructured":"P. B. Moulding R. S. Flannagan J. Wong A. M. Soliman W. Elhenawy D. E. Heinrichs O. M. El-Halfawy Discovery of broad-spectrum bacterial polyamine detoxification inhibitors as potential antivirulence agents and antibiotic adjuvants. bioRxiv 2024.10.18.618978 [Preprint] (2024). https:\/\/www.biorxiv.org\/content\/10.1101\/2024.10.18.618978v1.","DOI":"10.1101\/2024.10.18.618978"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00500"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00852-y"},{"key":"e_1_3_2_44_2","first-page":"CD014937","article-title":"Diuretics for preventing and treating acute kidney injury","volume":"1","author":"Hashimoto H.","year":"2025","unstructured":"H. Hashimoto, H. Yamada, M. Murata, N. Watanabe, Diuretics for preventing and treating acute kidney injury. Cochrane Database Syst. Rev. 1, CD014937 (2025).","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221086"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-135467"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2011.01.007"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154705"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.1.10600"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-052521-121810"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.022"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00737-6"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay3850"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adi7438"},{"key":"e_1_3_2_55_2","unstructured":"T. Hato Hato Lab Protocols public 1.0. Zenodo (2026); https:\/\/zenodo.org\/records\/21047325."},{"key":"e_1_3_2_56_2","unstructured":"T. Hato hato-lab\/MRSA-1.0. Zenodo (2026); https:\/\/zenodo.org\/records\/20161708."},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-021-00667-2"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b13317"},{"key":"e_1_3_2_59_2","first-page":"e53846","article-title":"Neutrophil isolation and analysis to determine their role in lymphoma cell sensitivity to therapeutic agents","volume":"2016","author":"Hirz T.","year":"2016","unstructured":"T. Hirz, C. Dumontet, Neutrophil isolation and analysis to determine their role in lymphoma cell sensitivity to therapeutic agents. J. Vis. Exp. 2016, e53846 (2016).","journal-title":"J. Vis. Exp."}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aed4200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:38Z","timestamp":1790791118000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aed4200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":58,"journal-issue":{"issue":"869","published-print":{"date-parts":[[2026,9,30]]}},"alternative-id":["10.1126\/scitranslmed.aed4200"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aed4200","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2025-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaed4200"}}