{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:47:55Z","timestamp":1791233275949,"version":"4.1.0"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"859","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK132399"],"award-info":[{"award-number":["R01DK132399"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032489","name":"Breakthrough T1D Canada","doi-asserted-by":"publisher","award":["3-SRA-2025-1641-M-B"],"award-info":[{"award-number":["3-SRA-2025-1641-M-B"]}],"id":[{"id":"10.13039\/100032489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,7,22]]},"abstract":"<jats:p>\n                    Sodium-glucose cotransporter-2 (SGLT2) inhibitors slow diabetic kidney disease progression, but their intrarenal mechanisms remain incompletely understood, particularly in type 1 diabetes (T1D), where kidney protection has not been definitively established. ATTEMPT (NCT04333823) was a placebo-controlled trial in which 98 youth (ages 12 to 21) with T1D and hyperfiltration were randomized 1:1 to dapagliflozin (5 milligrams) or placebo for 16 weeks. Participants underwent sequential kidney biopsies, multiparametric kidney MRI, and plasma and urine proteomics. The sequential research kidney biopsies were performed on adults 18 years or older at one of three sites (baseline\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a016, follow-up\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a011). Single-cell RNA sequencing of 214,415 cells across 27 biopsies revealed coordinated transcriptional shifts across nephron, vascular, and immune compartments. In the proximal tubule, the primary site of SGLT2 expression, dapagliflozin down-regulated glycolysis, gluconeogenesis, and oxidative stress markers. Endothelial cells showed reduced profibrotic and inflammatory gene expression with increased protective factors. Podocytes demonstrated enhanced cytoskeletal reinforcement and suppressed interferon signaling. These molecular changes paralleled clinical improvements, including attenuation of hyperfiltration, improved glycemic control, and normalization of medullary oxygenation. Trajectory analyses revealed dapagliflozin shifted tubular cells from injury-prone toward healthier phenotypes. Cross-cohort comparison against healthy controls showed that more than 55% of dapagliflozin-responsive genes shifted toward healthy control expression patterns. Urine proteomics mirrored tissue changes with decreased injury markers and increased protective proteins. These convergent molecular mechanisms, metabolic reprogramming, dampened inflammation, and normalized oxygen handling provide hypothesis-generating mechanistic insights into potential kidney-protective mechanisms of SGLT2 inhibitor therapy in youth with T1D.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aee1005","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:58:19Z","timestamp":1784743099000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["SGLT2 inhibition modulates metabolic, vascular, and inflammatory molecular markers in the kidney in youth with type 1 diabetes"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-2947","authenticated-orcid":true,"given":"Petter","family":"Bjornstad","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."},{"name":"Division of Endocrinology, Department of Pediatrics, University of Washington and Center for Clinical and Translational Research at Seattle Children\u2019s Research Institute, Seattle, WA 98101, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-175X","authenticated-orcid":true,"given":"Ye Ji","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoom","family":"Narongkiatikhun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."},{"name":"Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Karihaloo","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Complications, Novo Nordisk, Lexington, MA 02421, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4214-5465","authenticated-orcid":true,"given":"Pottumarthi V.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Radiology, Center for Advanced Imaging, Endeavor Health, Evanston, IL 60201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Center for Advanced Imaging, Endeavor Health, Evanston, IL 60201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1132-1574","authenticated-orcid":true,"given":"Kalie L.","family":"Tommerdahl","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."},{"name":"Division of Endocrinology, Department of Pediatrics, University of Washington and Center for Clinical and Translational Research at Seattle Children\u2019s Research Institute, Seattle, WA 98101, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9740-3023","authenticated-orcid":true,"given":"Maninderpal","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2778-9016","authenticated-orcid":true,"given":"Shivani","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-4283","authenticated-orcid":true,"given":"Carissa","family":"Birznieks","sequence":"additional","affiliation":[{"name":"Department of Integrated Physiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3001-0213","authenticated-orcid":true,"given":"Antoine","family":"Clarke","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesmino","family":"Elia","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-6373","authenticated-orcid":true,"given":"Jacqueline","family":"Curtis","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-6915","authenticated-orcid":true,"given":"Cheril","family":"Clarson","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, London Health Sciences Centre, London, ON N6A 5W9, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Weissenkampen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"D\u2019Antonio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9299-2048","authenticated-orcid":true,"given":"Jairo Arturo","family":"Pinzon Cortes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Hampson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-3446","authenticated-orcid":true,"given":"Long","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Immunology, Johns Hopkins University, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"van Eeghen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Amsterdam UMC, Amsterdam 1105 AZ, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-772X","authenticated-orcid":true,"given":"Jenny E.","family":"Kanter","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-6523","authenticated-orcid":true,"given":"Karin E.","family":"Bornfeldt","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7406-6606","authenticated-orcid":true,"given":"Tomas","family":"Vaisar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ladd","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital Colorado, Aurora, CO 80045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-3730","authenticated-orcid":true,"given":"Hiddo J. L.","family":"Heerspink","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen 9713 GZ, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-7592","authenticated-orcid":true,"given":"Ian H.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-0472","authenticated-orcid":true,"given":"Jesse A.","family":"Goodrich","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-5013","authenticated-orcid":true,"given":"Kelly","family":"Street","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2235-0103","authenticated-orcid":true,"given":"Katherine R.","family":"Tuttle","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Washington, Seattle, WA 98195, USA."},{"name":"Providence Medical Research Center, Providence Inland Northwest Health, Spokane, WA 99204, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly R.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency Medicine, Children\u2019s Minnesota, Minneapolis, MN 55404, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-9320","authenticated-orcid":true,"given":"Cathy","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medicine, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0534-3048","authenticated-orcid":true,"given":"Jeffrey B.","family":"Hodgin","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medicine, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8788-239X","authenticated-orcid":true,"given":"Jennifer A.","family":"Schaub","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medicine, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1657-954X","authenticated-orcid":true,"given":"Viji","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medicine, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6280-9639","authenticated-orcid":true,"given":"Rajasree","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medicine, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1602-9425","authenticated-orcid":true,"given":"Abhijit S.","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medicine, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-1931","authenticated-orcid":true,"given":"Phillip J.","family":"McCown","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medicine, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-7960","authenticated-orcid":true,"given":"Fadhl","family":"AlAkwaa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medicine, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8578-3443","authenticated-orcid":true,"given":"Sean","family":"Eddy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medicine, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2387-9973","authenticated-orcid":true,"given":"Edgar","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medicine, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4378-520X","authenticated-orcid":true,"given":"Nan Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Korea University Ansan Hospital, Ansan 15355, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7307-3786","authenticated-orcid":true,"given":"Robert G.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."},{"name":"Division of Research, Joslin Diabetes Center, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7735-5462","authenticated-orcid":true,"given":"Victor G.","family":"Puelles","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany."},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus 8200, Denmark."},{"name":"Hamburg Center for Kidney Health, Hamburg 20251, Germany."},{"name":"Department of Pathology, Aarhus University Hospital, Aarhus 8200, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00ebl H.","family":"van Raalte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Amsterdam UMC, Amsterdam 1105 AZ, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Z. I.","family":"Cherney","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Health Network, Toronto General Hospital Research Institute, Toronto, ON M5G 2C4, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-8221","authenticated-orcid":true,"given":"Laura","family":"Pyle","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and UW Medicine Diabetes Institute, University of Washington, Seattle, WA 98195, USA."},{"name":"Division of Endocrinology, Department of Pediatrics, University of Washington and Center for Clinical and Translational Research at Seattle Children\u2019s Research Institute, Seattle, WA 98101, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-3584","authenticated-orcid":true,"given":"Farid H.","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-0582","authenticated-orcid":true,"given":"Matthias","family":"Kretzler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medicine, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"101130","article-title":"Prevalence and severity of chronic kidney disease in a population with type 1 diabetes from a United States health system: A real-world cohort study","volume":"47","author":"Tuttle K. R.","year":"2025","unstructured":"K. R. Tuttle, C. L. Reynolds, L. M. Kornowske, C. R. Jones, R. Z. Alicic, K. B. Daratha, J. J. Neumiller, C. Greenbaum, M. E. Pavkov, F. Xu, O. K. Duru, S. B. Nicholas, K. C. Norris, CURE-CKD Consortium, Prevalence and severity of chronic kidney disease in a population with type 1 diabetes from a United States health system: A real-world cohort study. Lancet Reg. Health Am. 47, 101130 (2025).","journal-title":"Lancet Reg. Health Am."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00168-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811744"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204233"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000584"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI164486"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065517"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005081"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00565.2018"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03723-6"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI183984"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/534872"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205107"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126718"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.128120"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.07.007"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.11.007"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2024.105334"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-022-01700-3"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-10-0939"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02084-3"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157881"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2021.105960"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005734"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-2553"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-04958-7"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.70025"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2024.12640"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1105309"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14503"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12539"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200487"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1412271111"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092003"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07311009"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2024.10.013"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101837R"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.20233411S1757b"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac145"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2022.03.015"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.02.041"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00551.2017"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14890"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-02060-9"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.103"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.06.012"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15983-6"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-65410-9"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12993"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13811"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giaa151"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.133267"},{"key":"e_1_3_2_54_2","doi-asserted-by":"crossref","unstructured":"B. B. Lake R. Menon S. Winfree Q. Hu R. M. Ferreira K. Kalhor D. Barwinska E. A. Otto M. Ferkowicz D. Diep N. Plongthongkum A. Knoten S. Urata A. S. Naik S. Eddy B. Zhang Y. Wu D. Salamon J. C. Williams X. Wang K. S. Balderrama P. Hoover E. Murray A. Vijayan F. Chen S. S. Waikar S. Rosas F. P. Wilson P. M. Palevsky K. Kiryluk J. R. Sedor R. D. Toto C. Parikh E. H. Kim E. Z. Macosko P. V. Kharchenko J. P. Gaut J. B. Hodgin M. T. Eadon P. C. Dagher T. M. El-Achkar K. Zhang M. Kretzler S. Jain KPMP consortium An atlas of healthy and injured cell states and niches in the human kidney. bioRxiv 2021.07.28.454201 [Preprint]. 29 July 2021. https:\/\/doi.org\/10.1101\/2021.07.28.454201.","DOI":"10.1101\/2021.07.28.454201"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05769-3"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02146-6"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-3-r25"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4772-0"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac582"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aee1005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:58:32Z","timestamp":1784743112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aee1005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":58,"journal-issue":{"issue":"859","published-print":{"date-parts":[[2026,7,22]]}},"alternative-id":["10.1126\/scitranslmed.aee1005"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aee1005","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"assertion":[{"value":"2025-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaee1005"}}