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Transl. Med."],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:p>\n                    There is currently no approved vaccine for\n                    <jats:italic toggle=\"yes\">Shigella<\/jats:italic>\n                    spp., a leading cause of diarrhea with increasing rates of antimicrobial resistance.\n                    <jats:italic toggle=\"yes\">Shigella<\/jats:italic>\n                    vaccine development is complicated in part by an incomplete understanding of the structural and molecular determinants of immunity. To address this, we isolated monoclonal antibodies against candidate\n                    <jats:italic toggle=\"yes\">Shigella<\/jats:italic>\n                    vaccine antigens using samples from a\n                    <jats:italic toggle=\"yes\">Shigella flexneri<\/jats:italic>\n                    outbreak in a nonhuman primate (NHP) research facility. We found that antibodies targeting the\n                    <jats:italic toggle=\"yes\">Shigella<\/jats:italic>\n                    O-antigen can undergo substantial affinity maturation (&gt;10%) to acquire broad cross-reactivity across\n                    <jats:italic toggle=\"yes\">S. flexneri<\/jats:italic>\n                    serotypes. We also found that the virulence-associated type III secretion system (T3SS) proteins IpaD and IpaB elicit moderate T cell and robust antibody responses. T3SS antibodies could either inhibit or enhance bacterial virulence in vitro and differed in vivo depending on their epitope specificity. Collectively, these findings provide insights into protective and deleterious immune responses against\n                    <jats:italic toggle=\"yes\">Shigella<\/jats:italic>\n                    that directly inform vaccine immunogen design.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aef7084","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:58:11Z","timestamp":1788371891000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional antibody responses from a primate\n                    <i>Shigella<\/i>\n                    outbreak inform vaccine design"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1741-5336","authenticated-orcid":true,"given":"Robert M.","family":"Gallant","sequence":"first","affiliation":[{"name":"IAVI Neutralizing Antibody Center, San Diego, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0867-353X","authenticated-orcid":true,"given":"Paul","family":"Savarino","sequence":"additional","affiliation":[{"name":"IAVI Neutralizing Antibody Center, San Diego, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6189-4975","authenticated-orcid":true,"given":"Sophia","family":"Pulido","sequence":"additional","affiliation":[{"name":"IAVI Neutralizing Antibody Center, San Diego, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6746-6284","authenticated-orcid":true,"given":"Morgan S. 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