{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:55:10Z","timestamp":1790794510988,"version":"4.1.0"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"869","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1154805"],"award-info":[{"award-number":["1154805"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1163354"],"award-info":[{"award-number":["1163354"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:p>Scabies affects \u223c400 million people annually, yet current therapies lack ovicidal activity, require repeat dosing, and are increasingly compromised by treatment failure and resistance. The absence of a single-application therapy capable of eliminating both motile mites and eggs represents one important limitation to effective disease control. We developed a mechanism-informed topical therapy combining abametapir, a metalloprotease inhibitor with ovicidal activity, and flavesone, a \u03b2-triketone with rapid miticidal effects, designed to target multiple parasite life stages through distinct, non-neurotoxic mechanisms. Using a porcine model that closely recapitulates human scabies, we assessed efficacy, pruritus reduction, and pharmacologic exposure after topical administration. In severe scabies, a single 4-hour treatment eradicated all live mites and eggs and reduced pruritus, outperforming a standard two-dose oral ivermectin regimen. Skin pharmacokinetics demonstrated rapid attainment of concentrations with exposure profiles, supporting single-dose efficacy despite shorter systemic half-lives than ivermectin. Together, this promising therapeutic combination may offer a simplified and potentially resistance-resilient approach to scabies management.<\/jats:p>","DOI":"10.1126\/scitranslmed.aeg5917","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:33Z","timestamp":1790791113000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["A single-dose topical therapy cures scabies in a human-relevant porcine model"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3079-0985","authenticated-orcid":true,"given":"Deepani Darshika","family":"Fernando","sequence":"first","affiliation":[{"name":"Infection and Inflammation Program, QIMR Berghofer, 300 Herston Road, Herston, QLD 4006, Australia."},{"name":"School of Veterinary Science, University of Queensland, Cnr Main Drive and Outer Ring Road, Gatton, QLD 4343, Australia."},{"name":"School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5653-8131","authenticated-orcid":true,"given":"Sara","family":"Taylor","sequence":"additional","affiliation":[{"name":"Infection and Inflammation Program, QIMR Berghofer, 300 Herston Road, Herston, QLD 4006, Australia."},{"name":"School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-3293","authenticated-orcid":true,"given":"Gangi Rameshika","family":"Samarawickrama","sequence":"additional","affiliation":[{"name":"Infection and Inflammation Program, QIMR Berghofer, 300 Herston Road, Herston, QLD 4006, Australia."},{"name":"School of Veterinary Science, University of Queensland, Cnr Main Drive and Outer Ring Road, Gatton, QLD 4343, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6260-2168","authenticated-orcid":true,"given":"Nirupama Abeysekara","family":"Nammunige","sequence":"additional","affiliation":[{"name":"Infection and Inflammation Program, QIMR Berghofer, 300 Herston Road, Herston, QLD 4006, Australia."},{"name":"School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia."},{"name":"School of Biomedical Sciences, University of Queensland, St Lucia, QLD 4067, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-6450","authenticated-orcid":true,"given":"Gunter","family":"Hartel","sequence":"additional","affiliation":[{"name":"Statistics Unit, QIMR Berghofer, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6296-2358","authenticated-orcid":true,"given":"Vern","family":"Bowles","sequence":"additional","affiliation":[{"name":"Melbourne Veterinary School, University of Melbourne, 30 Flemington Rd, Parkville, VIC 3052, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3408-3337","authenticated-orcid":true,"given":"Katja","family":"Fischer","sequence":"additional","affiliation":[{"name":"Infection and Inflammation Program, QIMR Berghofer, 300 Herston Road, Herston, QLD 4006, Australia."},{"name":"School of Veterinary Science, University of Queensland, Cnr Main Drive and Outer Ring Road, Gatton, QLD 4343, Australia."},{"name":"School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization \u201cWHO informal consultation on a framework for scabies control\u201d (World Health Organization Manila 2019)."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19167"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3468"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2019.08.002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18517"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005920"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19786"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/421776"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2000.00417.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009751"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13851"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","unstructured":"C. Bernigaud D. D. Fernando K. Fischer O. Chosidow \u201cNew treatment solutions\u201d in Scabies K. Fischer O. Chosidow Eds. (Springer International Publishing 2023) pp. 459\u2013470.","DOI":"10.1007\/978-3-031-26070-4_30"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02334-17"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005030"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2022.2099376"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.07.074"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13612"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2026.01.019"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156321"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14092"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-82554-w"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.028662"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13875"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.10.023"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004384"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000756"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2011.11.002"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17538"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad308"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.61853\/mwn8bm85"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jme\/tjw132"},{"key":"e_1_3_2_33_2","first-page":"2333794x1983129","article-title":"Effect of a new head lice treatment, abametapir lotion, 0.74%, on louse eggs: A randomized, double-blind study","volume":"6","author":"Bowles V. M.","year":"2019","unstructured":"V. M. Bowles, S. Hanegraaf, T. Ahveninen, S. Sidgiddi, K. Allenby, H. Alsop, Effect of a new head lice treatment, abametapir lotion, 0.74%, on louse eggs: A randomized, double-blind study. Glob. Pediatr. Health 6, 2333794x19831295 (2019).","journal-title":"Glob. Pediatr. Health"},{"key":"e_1_3_2_34_2","unstructured":"US Food and Drug Administration XEGLYZE\u00ae (abametapir) lotion 0.74% prescribing information (US Food and Drug Administration 2020)."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/10600280211027968"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16111403"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13122016"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-023-03645-3"},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","unstructured":"N. A. Monteiro-Riviere J. Riviere \u201cThe pig as a model for cutaneous pharmacology and toxicology research\u201d in Advances in Swine in Biomedical Research: Volume 2 M. E. Tumbleson L. B. Schook Eds. (Springer US 1996) pp. 425\u2013458.","DOI":"10.1007\/978-1-4615-5885-9_2"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-016-0129-2"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198606000-00018"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aeg5917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:52Z","timestamp":1790791132000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aeg5917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":40,"journal-issue":{"issue":"869","published-print":{"date-parts":[[2026,9,30]]}},"alternative-id":["10.1126\/scitranslmed.aeg5917"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aeg5917","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaeg5917"}}