{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:04:35Z","timestamp":1783634675474,"version":"3.55.0"},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"257","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. STKE"],"published-print":{"date-parts":[[2004,11,2]]},"abstract":"<jats:p>\n            New discoveries are expanding our view of the role of nitric oxide (NO) in mammalian physiology by revealing new types, amounts, and fates of molecules modified in vivo by NO and its derivatives, as well as the profound augmentation of some of NO\u2019s actions at physiologic levels of O\n            <jats:sub>2<\/jats:sub>\n            . Investigators have identified a new form of endogenous reversible\n            <jats:italic>N<\/jats:italic>\n            -nitrosation reactions in vivo, that of proteins; a new class of endogenously nitrated bioactive molecules in vivo, nitro-fatty acids; and the ability of NO-dependent posttranslational modifications to control the half-life and destination of key regulatory proteins.\n          <\/jats:p>","DOI":"10.1126\/stke.2572004pe52","type":"journal-article","created":{"date-parts":[[2004,12,24]],"date-time":"2004-12-24T02:22:24Z","timestamp":1103854944000},"source":"Crossref","is-referenced-by-count":22,"title":["The Moving Frontier in Nitric Oxide\u2013Dependent Signaling"],"prefix":"10.1126","volume":"2004","author":[{"given":"Carl","family":"Nathan","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medical College, and Programs in Immunology and Microbial Pathogenesis and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1948068"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402201101"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/380221a0"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0503-496"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/35055104"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5414.651"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313853200"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.8.1123"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305888101"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18174"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00495-0"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306706101"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6451927"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307446101"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00295.2003"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.13.1675"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402587101"},{"key":"e_1_3_1_18_2","unstructured":"B. Freeman personal communication."},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00054-4"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401723101"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2433468100"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093891"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404161101"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00803-1"},{"key":"e_1_3_1_25_2","unstructured":"I thank B. Freeman for communicating results before publication and R. Bryk A. Ding and B. Freeman for comments on the manuscript. Preparation of this article was supported by grants from NIH. The Department of Microbiology and Immunology acknowledges the support of the William Randolph Hearst Foundation."}],"container-title":["Science's STKE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/stke.2572004pe52","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:17:33Z","timestamp":1705425453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/stke.2572004pe52"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,2]]},"references-count":25,"journal-issue":{"issue":"257","published-print":{"date-parts":[[2004,11,2]]}},"alternative-id":["10.1126\/stke.2572004pe52"],"URL":"https:\/\/doi.org\/10.1126\/stke.2572004pe52","relation":{},"ISSN":["1525-8882"],"issn-type":[{"value":"1525-8882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,2]]}}}