{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:55:59Z","timestamp":1781636159059,"version":"3.54.5"},"reference-count":10,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"270","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. STKE"],"published-print":{"date-parts":[[2005,2,8]]},"abstract":"<jats:p>\n            GABA\n            <jats:sub>A<\/jats:sub>\n            (\u03b3-aminobutyric acid type A) receptors are ligand-gated ion channels composed of five subunits, generally two \u03b1s, two \u03b2s, and a \u03b32. Recent research in which sets of subunits containing \u03b11 or \u03b16 subunits were artificially linked has revealed the importance of subunit position in determining GABA\n            <jats:sub>A<\/jats:sub>\n            receptor function. Sensitivity to benzodiazepines depended on juxtaposition of an \u03b11 subunit with the \u03b32 subunit, whereas sensitivity to furosemide depended only on the presence of an \u03b16 subunit and not on its specific location. The major utility of the linked subunit approach is to provide a mechanism for discovering the functional signatures of defined subunit arrangements, and thus a route to identifying such arrangements in vivo.\n          <\/jats:p>","DOI":"10.1126\/stke.2702005pe5","type":"journal-article","created":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T02:21:23Z","timestamp":1111630883000},"source":"Crossref","is-referenced-by-count":2,"title":["Alpha Subunit Position and GABA Receptor Function"],"prefix":"10.1126","volume":"2005","author":[{"given":"David R.","family":"Burt","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00505-8"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400220101"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105240200"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.07.005"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207663200"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-37-11778.2003"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-04-01151.2003"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-27-09004.2003"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200409042"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1301-04.2004"}],"container-title":["Science's STKE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/stke.2702005pe5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:18:08Z","timestamp":1705425488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/stke.2702005pe5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,8]]},"references-count":10,"journal-issue":{"issue":"270","published-print":{"date-parts":[[2005,2,8]]}},"alternative-id":["10.1126\/stke.2702005pe5"],"URL":"https:\/\/doi.org\/10.1126\/stke.2702005pe5","relation":{},"ISSN":["1525-8882"],"issn-type":[{"value":"1525-8882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,8]]}}}