{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:38:29Z","timestamp":1767922709785,"version":"3.49.0"},"reference-count":9,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"285","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. STKE"],"published-print":{"date-parts":[[2005,5,24]]},"abstract":"<jats:p>This Teaching Resource provides lecture notes and slides for a class covering proteases and signaling and is part of the course \"Cell Signaling Systems: A Course for Graduate Students.\" The lecture begins with a discussion of protease-activated receptors and the ubiquitin-proteasome system and then proceeds to describe some of the ways that proteolysis can function in signal transduction.<\/jats:p>","DOI":"10.1126\/stke.2852005tr15","type":"journal-article","created":{"date-parts":[[2005,6,24]],"date-time":"2005-06-24T00:14:01Z","timestamp":1119572041000},"source":"Crossref","is-referenced-by-count":2,"title":["Proteases and Signaling"],"prefix":"10.1126","volume":"2005","author":[{"given":"Sherwin","family":"Wilk","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb07287.x"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00028.2003"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)43856-8"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1983.tb08056.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2001"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5364.734"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(02)00283-7"},{"key":"e_1_3_1_8_2","first-page":"re4","volume":"2003","year":"2003","unstructured":"T. E. Golde, C. B. Eckman, Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis. Sci. STKE 2003, re4 (2003).12621149","journal-title":"Sci. STKE"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00525-6"}],"container-title":["Science's STKE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/stke.2852005tr15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T16:56:14Z","timestamp":1705424174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/stke.2852005tr15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,24]]},"references-count":9,"journal-issue":{"issue":"285","published-print":{"date-parts":[[2005,5,24]]}},"alternative-id":["10.1126\/stke.2852005tr15"],"URL":"https:\/\/doi.org\/10.1126\/stke.2852005tr15","relation":{},"ISSN":["1525-8882"],"issn-type":[{"value":"1525-8882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,24]]}}}