{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:33:47Z","timestamp":1773873227541,"version":"3.50.1"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4199","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1975,7,25]]},"abstract":"<jats:p>\n            The residual structural framework of the cell nucleus, termed the nuclear protein matrix, is associated with newly synthesized DNA in regenerating rat liver. One minute after rats are injected with [\n            <jats:sup>3<\/jats:sup>\n            H] thymidine, more than 90 percent of the total tritium in nuclear DNA is associated with the matrix DNA although this DNA comprises only 25 percent of the total nuclear DNA. In contrast, the bulk DNA, 75 percent of total nuclear DNA, contains less than 8 percent of the total labeled DNA. The percentage of total labeled DNA associated with the bulk DNA increases for 30 minutes after injection and decreases correspondingly in the matrix DNA.\n          <\/jats:p>","DOI":"10.1126\/science.1145202","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:11:22Z","timestamp":1160061082000},"page":"291-293","source":"Crossref","is-referenced-by-count":344,"title":["Nuclear Protein Matrix: Association with Newly Synthesized DNA"],"prefix":"10.1126","volume":"189","author":[{"given":"Ronald","family":"Berezney","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, James Buchanan Brady Laboratory for Reproductive Biology, and Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald S.","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, James Buchanan Brady Laboratory for Reproductive Biology, and Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","unstructured":"BARRACK E.R. THESIS JOHNS HOPKINS (1975)."},{"key":"e_1_2_1_2_1","first-page":"150","volume":"61","year":"1962","unstructured":"BENPORAT, T, SEPARATION OF NASCENT DEOXYRIBONUCLEIC ACID FROM REMAINDER OF CELLULAR DEOXYRIBONUCLEIC ACID, BIOCHIMICA ET BIOPHYSICA ACTA 61: 150 (1962).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/0006-291X(74)90355-6","volume":"60","year":"1974","unstructured":"BEREZNEY, R, IDENTIFICATION OF A NUCLEAR PROTEIN MATRIX, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 60: 1410 (1974).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1016\/S0021-9258(20)81140-5","volume":"247","year":"1972","unstructured":"BEREZNEY, R, PURIFICATION AND BIOCHEMICAL CHARACTERIZATION OF BOVINE LIVER NUCLEAR MEMBRANES, JOURNAL OF BIOLOGICAL CHEMISTRY 247: 5549 (1972).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_5_1","first-page":"205","year":"1974","unstructured":"Berezney, R., Methods in Cell Biology: 205 (1974).","journal-title":"Methods in Cell Biology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0092-8674(74)90004-X","volume":"2","year":"1974","unstructured":"BERGER, H, STUDIES ON NASCENT DNA IN MOUSE MYELOMA, CELL 2: 23 (1974).","journal-title":"CELL"},{"key":"e_1_2_1_7_1","first-page":"152","volume":"65","year":"1970","unstructured":"BERGER, H, CHANGES IN PHYSICAL STATE OF DNA DURING REPLICATION IN REGENERATING LIVER OF RAT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 65: 152 (1970).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1016\/S0021-9258(19)44578-X","volume":"247","year":"1972","unstructured":"BROWN, D.G., EFFECTS OF POLYINOSINIC ACID AND POLYCYTIDYLIC ACID ON DEOXYRIBONUCLEIC ACID TEMPLATE ACTIVITY OF ISOLATED NUCLEI AND SOLUBLE CHROMATIN FROM RAT-LIVER, JOURNAL OF BIOLOGICAL CHEMISTRY 247: 7674 (1972).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0005-2787(69)90485-7","volume":"186","year":"1969","unstructured":"BUCHER, NLR, THYMIDINE TRIPHOSPHATE CONTENT OF REGENERATING RAT LIVER, BIOCHIMICA ET BIOPHYSICA ACTA 186: 13 (1969).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0076-6879(67)12127-7","volume":"12","year":"1968","unstructured":"BURTON, K, METHODS ENZYMOLOGY B 12: 163 (1968).","journal-title":"METHODS ENZYMOLOGY B"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","unstructured":"Busch H. The Nucleolus (1970).","DOI":"10.1055\/s-1970-21592"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/bjc.1968.101","volume":"22","year":"1968","unstructured":"CHANG, L.O., RATES OF INCORPORATION OF TRITIUM-LABELED THYMIDINE INTO MITOCHONDRIAL AND NUCLEAR DNA OF NORMAL RAT LIVER REGENERATING LIVER AND 4 HEPATOMAS WITH DIFFERENT GROWTH RATES AND THEIR HOST LIVERS, BRITISH JOURNAL OF CANCER 22: 860 (1968).","journal-title":"BRITISH JOURNAL OF CANCER"},{"key":"e_1_2_1_13_1","first-page":"1817","volume":"25","year":"1965","unstructured":"CHANG, L.O., A BIOCHEMICAL AND AUTORADIOGRAPHIC STUDY OF IN VIVO UTILIZATION OF TRITIATED THYMIDINE IN REGENERATING RAT LIVER, CANCER RESEARCH 25: 1817 (1965).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_14_1","first-page":"440","volume":"20","year":"1968","unstructured":"COMINGS, D.E., RATIONALE FOR AN ORDERED ARRANGEMENT OF CHROMATIN IN INTERPHASE NUCLEUS, AMERICAN JOURNAL OF HUMAN GENETICS 20: 440 (1968).","journal-title":"AMERICAN JOURNAL OF HUMAN GENETICS"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0022-2836(68)90290-8","volume":"33","year":"1968","unstructured":"COMINGS, D.E., INITIATION OF DEOXYRIBONUCLEIC ACID REPLICATION AT NUCLEAR MEMBRANE IN HUMAN CELLS, JOURNAL OF MOLECULAR BIOLOGY 33: 225 (1968).","journal-title":"JOURNAL OF MOLECULAR BIOLOGY"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0022-2836(73)90295-7","volume":"75","year":"1973","unstructured":"COMINGS, D.E., DNA-REPLICATION AND NUCLEAR MEMBRANE, JOURNAL OF MOLECULAR BIOLOGY 75: 609 (1973).","journal-title":"JOURNAL OF MOLECULAR BIOLOGY"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0014-4827(69)90493-5","volume":"55","year":"1969","unstructured":"FABRIKANT, J.I., SIZE OF PROLIFERATING POOLS IN REGENERATING LIVER, EXPERIMENTAL CELL RESEARCH 55: 277 (1969).","journal-title":"EXPERIMENTAL CELL RESEARCH"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0014-4827(74)90692-2","volume":"83","year":"1974","unstructured":"FAKAN, S, LOCALIZATION OF NEWLY-SYNTHESIZED DNA IN A MAMMALIAN-CELL AS VISUALIZED BY HIGH-RESOLUTION AUTORADIOGRAPHY, EXPERIMENTAL CELL RESEARCH 83: 95 (1974).","journal-title":"EXPERIMENTAL CELL RESEARCH"},{"key":"e_1_2_1_19_1","first-page":"2300","volume":"69","year":"1972","unstructured":"FAKAN, S, SITES OF REPLICATION OF CHROMOSOMAL DNA IN A EUKARYOTIC CELL, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 2300 (1972).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0014-4827(73)90527-2","volume":"81","year":"1973","unstructured":"FRANKE, W.W., NUCLEAR MEMBRANES FROM MAMMALIAN LIVER .4. CHARACTERIZATION OF MEMBRANE-ATTACHED DNA, EXPERIMENTAL CELL RESEARCH 81: 365 (1973).","journal-title":"EXPERIMENTAL CELL RESEARCH"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0005-2787(69)90249-4","volume":"174","year":"1969","unstructured":"FRIEDMAN, D.L., STUDIES ON NATURE OF REPLICATING DNA OF HELA CELLS, BIOCHIMICA ET BIOPHYSICA ACTA 174: 253 (1969).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_22_1","first-page":"1278","volume":"33","year":"1974","unstructured":"GENTA, V.M., ISOLATION OF A NUCLEAR FRACTION ENRICHED IN NASCENT DNA AND DNA REPLICATIVE ACTIVITY, FEDERATION PROCEEDINGS 33: 1278 (1974).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/0005-2787(68)90168-8","volume":"157","year":"1968","unstructured":"GROSS, N, THYMIDINE CONTENT AND TURNOVER IN RAT, BIOCHIMICA ET BIOPHYSICA ACTA 157: 648 (1968).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0005-2787(69)90655-8","volume":"195","year":"1969","unstructured":"HABENER, J.F., CHANGES IN SEDIMENTATION PROPERTIES OF HELA CELL DNA AND NUCLEOPROTEIN DURING REPLICATION, BIOCHIMICA ET BIOPHYSICA ACTA 195: 484 (1969).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0006-291X(71)90537-7","volume":"42","year":"1971","unstructured":"HANOAKA, F, BIOCH BIOPHYS RES CO 42: 647 (1971).","journal-title":"BIOCH BIOPHYS RES CO"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/0006-291X(73)90740-7","volume":"52","year":"1973","unstructured":"HEWISH, D.R., CHROMATIN SUB-STRUCTURE - DIGESTION OF CHROMATIN DNA AT REGULARLY SPACED SITES BY A NUCLEAR DEOXYRIBONUCLEASE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 52: 504 (1973).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/241032a0","volume":"241","year":"1973","unstructured":"HUBERMAN, J.A., DNA-REPLICATION SITES WITHIN NUCLEI OF MAMMALIAN-CELLS, NATURE 241: 32 (1973).","journal-title":"NATURE"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0006-291X(73)91104-2","volume":"55","year":"1973","unstructured":"HYODO, M, DNA-REPLICATION AND NUCLEAR ENVELOPE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 55: 424 (1973).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_29_1","first-page":"5","volume":"242","year":"1973","unstructured":"INFANTE, A.A., DNA-SYNTHESIS IN DEVELOPING SEA-URCHINS - ROLE OF A DNA-NUCLEAR MEMBRANE COMPLEX, NATURE-NEW BIOLOGY 242: 5 (1973).","journal-title":"NATURE-NEW BIOLOGY"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0006-291X(71)80097-9","volume":"43","year":"1971","unstructured":"KAWAFAKADA, M.Y., BIOCHEM BIOPHYS RES 43: 133 (1971).","journal-title":"BIOCHEM BIOPHYS RES"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0014-5793(71)80358-7","volume":"16","year":"1971","unstructured":"KAY, R.R., LATE REPLICATION OF DNA ASSOCIATED WITH NUCLEAR MEMBRANE, FEBS LETTERS 16: 233 (1971).","journal-title":"FEBS LETTERS"},{"key":"e_1_2_1_32_1","first-page":"1278","volume":"33","year":"1974","unstructured":"KIZER, D.E., LABELED INORGANIC-PHOSPHATE OR THYMIDINE AS INDICATORS OF STIMULATED DNA-SYNTHESIS IN REGENERATING RAT-LIVER, FEDERATION PROCEEDINGS 33: 1278 (1974).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_33_1","first-page":"2236","volume":"71","year":"1974","unstructured":"LEBLANC, D, LOCALIZATION OF REPLICATING DNA OF SIMIAN VIRUS 40 IN MONKEY KIDNEY-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 2236 (1974).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1432-1033.1967.tb19498.x","volume":"3","year":"1967","unstructured":"LEVIS, A.G., A FRACTION OF NEWLY SYNTHESIZED DNA OF HELA CELLS, EUROPEAN JOURNAL OF BIOCHEMISTRY 3: 57 (1967).","journal-title":"EUROPEAN JOURNAL OF BIOCHEMISTRY"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0022-2836(71)90315-9","volume":"59","year":"1971","unstructured":"MIZUNO, N.S., NATURE OF DNA ASSOCIATED WITH NUCLEAR ENVELOPE OF REGENERATING LIVER, JOURNAL OF MOLECULAR BIOLOGY 59: 517 (1971).","journal-title":"JOURNAL OF MOLECULAR BIOLOGY"},{"key":"e_1_2_1_36_1","first-page":"22","volume":"229","year":"1971","unstructured":"MIZUNO, N.S., DNA SYNTHESIS ASSOCIATED WITH INNER MEMBRANE OF NUCLEAR ENVELOPE, NATURE-NEW BIOLOGY 229: 22 (1971).","journal-title":"NATURE-NEW BIOLOGY"},{"key":"e_1_2_1_37_1","first-page":"113","volume":"14","year":"1966","unstructured":"MUNRO, H.N., METHODS BIOCHEMICAL 14: 113 (1966).","journal-title":"METHODS BIOCHEMICAL"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0014-4827(67)90409-0","volume":"46","year":"1967","unstructured":"NARAYAN, S, EXP CELL RE 46: 65 (1967).","journal-title":"EXP CELL RE"},{"key":"e_1_2_1_39_1","first-page":"1017","volume":"65","year":"1970","unstructured":"NUZZO, F, DNA REPLICATION IN MAMMALIAN CELLS .1. SIZE OF NEWLY SYNTHESIZED HELICES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 65: 1017 (1970).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_40_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0014-4827(73)90305-4","volume":"80","year":"1973","unstructured":"OBRIEN, R.L., DNA-REPLICATION SITES IN HELA-CELLS, EXPERIMENTAL CELL RESEARCH 80: 340 (1973).","journal-title":"EXPERIMENTAL CELL RESEARCH"},{"key":"e_1_2_1_41_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0014-4827(72)90198-X","volume":"70","year":"1972","unstructured":"OCKEY, C.H., DISTRIBUTION OF DNA REPLICATOR SITES IN MAMMALIAN NUCLEI .2. EFFECTS OF PROLONGED INHIBITION OF DNA-SYNTHESIS, EXPERIMENTAL CELL RESEARCH 70: 203 (1972).","journal-title":"EXPERIMENTAL CELL RESEARCH"},{"key":"e_1_2_1_42_1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/2211215a0","volume":"221","year":"1969","unstructured":"Painter, R. B., Nature 221:1215 (1969).","journal-title":"Nature"},{"key":"e_1_2_1_43_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0006-291X(69)90830-4","volume":"34","year":"1969","unstructured":"SCHANDL, E.K., EARLY EVENTS IN REPLICATION AND INTEGRATION OF DNA INTO MAMMALIAN CHROMOSOMES, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 34: 291 (1969).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_44_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0014-4827(63)90169-1","volume":"31","year":"1963","unstructured":"SMETANA, K, A NUCLEAR RIBONUCLEOPROTEIN NETWORK, EXPERIMENTAL CELL RESEARCH 31: 198 (1963).","journal-title":"EXPERIMENTAL CELL RESEARCH"},{"key":"e_1_2_1_45_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0005-2787(66)90008-6","volume":"129","year":"1966","unstructured":"STEELE, W.J., STUDIES ON RIBONUCLEIC ACID COMPONENTS OF NUCLEAR RIBONUCLEOPROTEIN NETWORK, BIOCHIMICA ET BIOPHYSICA ACTA 129: 54 (1966).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_46_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0014-4827(70)90224-7","volume":"63","year":"1970","unstructured":"WILLIAMS, C.A., EXP CELL RES 63: 365 (1970).","journal-title":"EXP CELL RES"},{"key":"e_1_2_1_47_1","first-page":"714","volume":"70","year":"1973","unstructured":"WISE, G.E., INITIATION AND CONTINUATION OF DNA-REPLICATION ARE NOT ASSOCIATED WITH NUCLEAR ENVELOPE IN MAMMALIAN-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70: 714 (1973).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_48_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0014-4827(62)90021-6","volume":"27","year":"1962","unstructured":"ZBARSKY, I.B., STRUCTURE OF TUMOR CELL NUCLEI, EXPERIMENTAL CELL RESEARCH 27: 573 (1962).","journal-title":"EXPERIMENTAL CELL RESEARCH"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1145202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T07:59:13Z","timestamp":1704873553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1145202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,7,25]]},"references-count":48,"journal-issue":{"issue":"4199","published-print":{"date-parts":[[1975,7,25]]}},"alternative-id":["10.1126\/science.1145202"],"URL":"https:\/\/doi.org\/10.1126\/science.1145202","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,7,25]]}}}