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The folding topology of this domain is identical to that of the extracellular domains of the human growth hormone receptor, the second domain of CD4, and PapD. Although distinct, this topology is similar to that of immunoglobulin constant domains. An Arg-Gly-Asp (RGD) sequence that can function for cell adhesion is found in a tight turn on an exposed loop.<\/jats:p>","DOI":"10.1126\/science.1279805","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:03:06Z","timestamp":1160089386000},"page":"987-991","source":"Crossref","is-referenced-by-count":431,"title":["Structure of a Fibronectin Type III Domain from Tenascin Phased by MAD Analysis of the Selenomethionyl Protein"],"prefix":"10.1126","volume":"258","author":[{"given":"Daniel J.","family":"Leahy","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne A.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"lkramuddin","family":"Aukhil","sequence":"additional","affiliation":[{"name":"Department of Periodontics, University of North Carolina Dental School, Chapel Hill, NC 27514."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold P.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical School, Durham, NC 27710."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/337709a0","volume":"337","year":"1989","unstructured":"ACHARYA, R, THE 3-DIMENSIONAL STRUCTURE OF FOOT-AND-MOUTH-DISEASE VIRUS AT 2.9-A RESOLUTION, NATURE 337: 709 (1989).","journal-title":"NATURE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1862345"},{"key":"e_1_2_1_3_1","unstructured":"AUKHIL I unpublished data."},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1021\/bi00122a025","volume":"31","year":"1992","unstructured":"BARON, M, H-1-NMR ASSIGNMENT AND SECONDARY STRUCTURE OF THE CELL-ADHESION TYPE-III MODULE OF FIBRONECTIN, BIOCHEMISTRY 31: 2068 (1992).","journal-title":"BIOCHEMISTRY"},{"key":"e_1_2_1_5_1","first-page":"6934","volume":"87","year":"1990","unstructured":"BAZAN, J.F., STRUCTURAL DESIGN AND MOLECULAR EVOLUTION OF A CYTOKINE RECEPTOR SUPERFAMILY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 6934 (1990).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1083\/jcb.108.3.1149","volume":"108","year":"1989","unstructured":"BOURDON, M.A., TENASCIN MEDIATES CELL ATTACHMENT THROUGH AN RGD-DEPENDENT RECEPTOR, JOURNAL OF CELL BIOLOGY 108: 1149 (1989).","journal-title":"JOURNAL OF CELL BIOLOGY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1107\/S0108767390002355","volume":"46","year":"1990","unstructured":"BRUNGER, A.T., SLOW-COOLING PROTOCOLS FOR CRYSTALLOGRAPHIC REFINEMENT BY SIMULATED ANNEALING, ACTA CRYSTALLOGRAPHICA SECTION A 46: 585 (1990).","journal-title":"ACTA CRYSTALLOGRAPHICA SECTION A"},{"key":"e_1_2_1_8_1","unstructured":"Brunger A. 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